10-K – Annual report [Section 13 and 15(d), not S-K Item 405]

Bristol-Myers Squibb has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission .

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Ligand to Report Fourth Quarter Financial Results on February 17

On February 9, 2022 Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) will report fourth quarter 2021 financial results after the close of the U.S. financial markets on Thursday, February 17, 2022 and will hold a conference call that same day beginning at 4:30 p.m. Eastern time (Press release, Ligand, FEB 9, 2022, View Source [SID1234607893]). Speakers on the call will include Ligand’s CEO John Higgins, President and COO Matt Foehr and Executive Vice President and CFO Matt Korenberg.

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Conference Call and Webcast Information

Live and replay webcast of the call are available here.

Crinetics Pharmaceuticals to Participate in SVB Leerink Global Healthcare Conference

On February 9, 2022 Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a clinical-stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors, reported that company management will participate in a fireside chat at the annual SVB Leerink Global Healthcare Conference, which is being held in a virtual format February 14-18, 2022 (Press release, Crinetics Pharmaceuticals, FEB 9, 2022, View Source [SID1234607909]).

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Details of the presentation are as follows:

Date: Wednesday, February 16, 2022
Time: 1:00 p.m. Eastern Time
Webcast Link: View Source
In addition, the live and archived presentation will be accessible on the Events & Presentations page in the Investors section on the Company’s website.

Elpiscience Announces CDE Clearance of IND Application for Anti-CD39 Monoclonal Antibody ES002

On February 9, 2022 Elpiscience Biopharmaceuticals, Inc. ("Elpiscience"), a global clinical-stage biopharmaceutical company dedicated to discovering and developing next-generation cancer immunotherapies, reported that the Center of Drug Evaluation (CDE) has cleared Elpiscience’s Investigational New Drug Application (IND) for ES002 to initiate a Phase I clinical trial in China (Press release, Elpiscience, FEB 9, 2022, View Source [SID1234607924]).

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ES002 is a proprietary anti-CD39 monoclonal antibody (mAb), which has demonstrated highly potent single-agent anti-tumor activity showing a significant reduction in tumor size in in vivo pharmacology studies.

"We are delighted that our IND application for ES002 is approved by the CDE, which follows the earlier IND and Phase I clinical study initiation in the US," said Dr. Steve Chin, CMO of Elpiscience. "Robust preclinical data suggests that our anti-CD39 mAb has a potential best-in-class profile, including a strong effect on T cell function and superior enzymatic inhibition. We look forward to initiating the study in China and potential clinical benefits ES002 may offer for patients with solid tumors worldwide."

About ES002:

ES002 is an anti-CD39 mAb designed to promote anti-tumor immunity. CD39 is a key enzyme regulating the production of adenosine, a critical immune suppressor. By blocking CD39 function, ES002 also stabilizes pro-inflammatory extracellular ATP (eATP) and restores anti-tumor immunity within the tumor microenvironment. ES002 demonstrated highly potent single-agent anti-tumor activity in in-vivo pharmacology studies and is currently in a Phase 1 clinical trial in the US (NCT05075564).

Mevion Selected to Equip New Proton Therapy and Research Center in San Antonio

On February 9, 2022 Mevion Medical Systems and Proton International reported the selection of the MEVION S250i Proton Therapy System with HYPERSCAN Pencil Beam Scanning (PBS) to equip the UT Health San Antonio Proton Therapy and Research Center (Press release, Mevion Medical Systems, FEB 9, 2022, View Source [SID1234607941]). It will be the first proton therapy system in San Antonio and South Texas to provide this advanced alternative to conventional radiation therapy for cancer.

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Proton therapy targets cancer cells more precisely than traditional x-ray photon therapy, and results in less damage to surrounding healthy tissue and sensitive organs such as the brain, heart, spine, and lungs. This provides a significant reduction in acute adverse events and hospitalization along with a decreased risk of secondary malignancies when compared to traditional x-ray photon therapy. It is the preferred modality for treating pediatric patients, who are particularly susceptible to the potential side effects of radiation therapy.

"Bringing the most advanced technology to serve our patients with the highest quality care is essential," said Mark Bonnen, MD, chief medical officer of the Mays Cancer Center. The MEVION S250i with HYPERSCAN has advanced the benefits of proton therapy by enabling faster and sharper delivery of therapeutic radiation. The system’s leading-edge clinical capabilities, combined with its compact, affordable design, industry-leading ramp-up time, and environmentally friendly energy use have helped expand access proton therapy to patients worldwide. The new proton center will be built adjacent to The University of Texas Health Science Center’s Greehey Children’s Cancer Research Institute and the world-renowned, NCI-designated Mays Cancer Center that will provide clinical and research expertise in the new center and oversee all research and academic training.

"Mevion is honored to partner with UT Health San Antonio and Proton International to bring our life-saving technology close to home for patients in South Texas," said Tina Yu, Ph.D., chief executive officer and president of Mevion. "In the past 5 years, proton therapy has moved away from large multi-room centers to single-room systems and with this system, our seventh NCI-designated center partnership, it solidifies our 62% market leadership in the U.S. compact proton therapy market."

"The Proton International team is pleased to be working with our partners to bring this important technology to the citizens of San Antonio and the surrounding region. Our collective vision is to assure this technology will be available in the fight against cancer and will make a real difference in patients’ lives" said Chris Chandler, CEO of Proton International.