On March 18, 2026 Circle Pharma, Inc., a clinical-stage biopharmaceutical company pioneering next-generation targeted macrocycle therapeutics for cancer, reported upcoming presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 17-22 in San Diego.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Presentations will highlight progress across Circle Pharma’s cyclin inhibitor programs and its MXMO platform, including preclinical findings and an oral plenary highlighting early clinical activity for CID-078, a first-in-class, orally bioavailable macrocyclic cyclin A/B RxL inhibitor currently being evaluated in a Phase 1 clinical trial for patients with advanced solid tumors.

Details of the presentations are as follows:

Oral Presentations

Title: Early clinical activity from the phase 1 evaluation of CID-078, a novel Cyclin A/B-RxL inhibitor, in patients with advanced solid tumors
Session Title: Clinical Trials Plenary Session: New Frontiers in Precision Oncology
Date & Time: Sunday, April 19, 1:00-3:00 p.m. PST
Presenter: Afshin Dowlati, M.D.

Title: Discovery of CID-078, a first-in-class oral macrocycle cyclin A/B-RxL inhibitor, for the treatment of cancers with RB1 loss or hyperactivated E2F
Session Title: New Drugs on the Horizon: Part 3
Date & Time: Monday, April 20, 10:15-11:45 a.m. PST
Presenter: Marie Evangelista, Ph.D.

Poster Presentation

Title: Orally Bioavailable Peptide Macrocycles Disrupting Intracellular Protein-Protein Interactions: Selective Inhibitors of the RxL-binding Site of Cyclin Family Proteins
Session Title: Chemistry to the Clinic Part 3 of 4: Novel Modalities, Targets, and Mechanisms in Drugging Oncogenic Pathways
Date & Time: Saturday, April 18, 12:30-2:00 p.m. PST
Presenter: Justin Shapiro, Ph.D.

About CID-078, Circle Pharma’s Oral Cyclin A/B RxL Inhibitor Program
CID-078 is an orally bioavailable macrocycle with dual activity blocking protein-protein interactions between both cyclins A and B and key substrates that bind to them via conserved RxL motifs. CID-078 selectively targets tumor cells with oncogenic alterations that cause cell cycle dysregulation, including alterations in the tumor suppressor RB1. In preclinical studies, Circle Pharma’s cyclin A/B RxL inhibitors have been shown to potently and selectively disrupt the protein-to-protein interaction between cyclins A and B and their key substrates and modulators, including E2F (a substrate of cyclin A) and MYT1 (a modulator of cyclin B). Preclinical studies have demonstrated the ability of these cyclin A/B RxL inhibitors to cause single-agent tumor regressions in multiple in vivo models. A multicenter Phase 1 clinical trial (NCT06577987) is currently enrolling patients with advanced solid tumors harboring RB1 alterations.

(Press release, Circle Pharma, MAR 18, 2026, View Source [SID1234663698])

On March 18, 2026 IDEAYA Biosciences, Inc. (NASDAQ: IDYA), a leading precision medicine oncology company, reported the publication of abstracts for three poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 17-22 in San Diego, California. The presentations will highlight preclinical data from three potential first-in-class programs from IDEAYA’s clinical stage pipeline: IDE034, a PTK7/B7H3 bi-specific topoisomerase-1 (TOP1) antibody-drug conjugate (ADC); IDE574, a potent dual inhibitor of the lysine acetyltransferase (KAT) 6 and 7; and IDE892, an MTA-cooperative inhibitor of PRMT5. The company is currently conducting Phase 1 clinical studies to evaluate safety, tolerability, PK and efficacy of these three programs across a broad range of large solid tumor indications, including lung, colorectal, pancreatic, breast, and prostate cancer.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We are excited for the opportunity to showcase data from our earlier stage clinical pipeline at this year’s AACR (Free AACR Whitepaper). These programs align closely with our clinical focus within TOP1 ADCs and DNA damage repair (DDR) mechanisms, synthetic lethality and modulation of epigenetic pathways to overcome resistance mechanisms in cancer. Our goal is to identify first-in-class and best-in-class product profiles to deliver robust monotherapy efficacy and rational combinations that have the potential to drive deeper, more durable responses for patients living with cancer," said Michael White, Ph.D., Chief Scientific Officer of IDEAYA Biosciences.

Details of the poster presentations are as follows:

Author: Munoz Delgado, D. et al.
Title: IDE034, A bispecific antibody-drug conjugate co-targeting PTK7 and B7-H3, exhibits avidity-driven selectivity and enhanced antitumor activity versus mono-specific ADCs
Poster Number: 232
Session Title: DNA Damage and Repair 1

Date and Time: Sunday, April 19, 2026 at 2:00pm-5:00pm PDT

Author: Gupta, M. et al.
Title: The KAT6/7 inhibitor IDE574 disrupts tumor lineage identity and drug tolerance to deliver robust antitumor activity in biomarker selected indications
Poster Number: 4483
Session Title: Epigenetic Modulators 1

Date and Time: Tuesday, April 21, 2026 at 9:00am-12:00pm PDT

Author: Rao, A. et al.
Title: IDE892 is a highly potent and selective PRMT5 inhibitor, with MTA-positive and SAM-negative cooperativity, optimized for development in MTAP-del cancers in combination with the allosteric MAT2A inhibitor IDE397
Poster Number: 4505
Session Title: Epigenetic Modulators 1

Date and Time: Tuesday, April 21, 2026 at 9:00am-12:00pm PDT

The poster presentations will be made available on IDEAYA’s corporate website following the meeting: View Source

(Press release, Ideaya Biosciences, MAR 18, 2026, View Source [SID1234663714])

On March 18, 2026 Medicenna Therapeutics Corp. ("Medicenna" or the "Company") (TSX: MDNA, OTCQX: MDNAF), a clinical-stage immunotherapy company focused on the development of Superkines targeting cancer and autoimmune diseases, reported that updated pre-clinical data for MDNA113, its first-in-class PD-1 x IL-2 bifunctional superkine advancing toward an IND submission in H2 2026, will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, taking place April 17–22 in San Diego, California.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details for the presentation are as follows:

Title: MDNA113 is a masked conditionally activated tumor-targeted anti-PD1-IL-2SK with superior safety and therapeutic properties.
Session Title: Monoclonal Antibodies and Antibody-Cytokine Platforms
Session Date and Time: Tuesday, April 21st, 2026; 9:00 AM – 12:00 PM
Location: Poster Section 9
Poster Board Number: 13
Abstract Number: 4342

Following the presentation, a copy will be available on the "Scientific Presentations" page of Medicenna’s website.

About MDNA113:

MDNA113 is a novel, first-in-class tumor-targeted and tumor-activated bi-functional anti-PD1-IL-2 Superkine with exceptionally high affinity for IL-13Rα2 without binding to the functional IL-13R⍺1. IL-13Rα2 is overexpressed in a wide range of solid tumors, including cold tumors with minimal to no expression in normal tissues. IL-13Rα2 expressing tumors also have abundant matrix metalloprotease in the tumor microenvironment that may efficiently activate MDNA113. IL-13Rα2 expression is associated with poor clinical outcome in multiple tumor types including prostate, pancreatic, ovarian, liver, breast and brain cancer, with an annual world-wide incidence of over 2 million.

(Press release, Medicenna Therapeutics, MAR 18, 2026, View Source [SID1234663731])

On March 28, 2026 XOMA Royalty Corporation (NASDAQ: XOMA), the biotech royalty aggregator, reported its 2025 fourth quarter and full year financial results and highlighted recent actions that have the potential to deliver additional shareholder value.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We continue to search for innovative ways to drive enhanced optionality in the XOMA portfolio, with the addition of 22 assets and two platform technologies over the past year," stated Owen Hughes, Chief Executive Officer of XOMA Royalty. "With multiple commercial assets delivering growing royalty receipts, we achieved positive cash flow from operations and were able to return $16 million of capital through a share buyback in 2025. Looking ahead, with 14 programs in registrational studies, we anticipate a number of catalysts over the ensuing years, including several regulatory updates and late-stage clinical readouts in 2026, which, if positive, will further diversify our commercial royalty streams and drive growing free cash flow in 2027 and beyond."

Portfolio Updates

Day One
•

OJEMDA New Drug Application filing in Japan triggered $2 million milestone in 4Q25

•

OJEMDA FY 2026 revenue guidance of $225 – $250 million2

•

In February 2026, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion recommending the conditional marketing authorization of OJEMDA3

•

In March 2026, Day One and Servier announced that they have entered into a definitive agreement for Servier to acquire Day One for $21.50 per share in cash, representing a total equity value of approximately $2.5 billion4

Zevra Therapeutics
•

A Marketing Authorization Application for the evaluation of arimoclomol (MIPLYFFA) for the treatment of NPC is under review by the EMA5

Rezolute
•

In December 2025, Rezolute announced that the Phase 3 clinical study of ersodetug for the treatment of congenital hyperinsulinism ("HI") demonstrated reductions from baseline in hypoglycemia events by self-monitored blood glucose at both ersodetug dose levels, but the reductions were not statistically significant compared to placebo, due to a pronounced study effect6

•

Rezolute will meet with FDA under its Breakthrough Therapy Designation in the first quarter of 2026 to determine next steps for the program6

•

Rezolute anticipates topline results of upLIFT, a Phase 3, single-arm, open-label study in participants with tumor HI, in the second half of 20266

Gossamer Bio & Chiesi
•

In February 2026, Gossamer Bio announced topline results from the Phase 3 PROSERA clinical trial evaluating seralutinib for the treatment of PAH7

•

Seralutinib demonstrated a placebo-adjusted improvement in Six-Minute Walk Distance (6MWD) of +13.3 meters at Week 24 (p = 0.0320), missing the prespecified alpha threshold of 0.0257

•

Gossamer plans to meet with the U.S. FDA to discuss the path forward7

2
View Source

3
View Source
children-with-relapsed-or-refractory-braf-altered-pediatric-low-grade-glioma-3246394/

4
View Source

5
View Source

6
View Source

7
View Source

Volixibat
•

Volixibat VISTAS study in primary sclerosing cholangitis (PSC) topline data expected in Q2 20268

•

Volixibat VANTAGE study in primary biliary cholangitis (PBC) expected to complete enrollment in H2 20268

Business Development Activity

Takeda Strategic Royalty Share Transaction
•

In December 2025, XOMA amended its collaboration with Takeda

•

XOMA will receive low to mid-single-digit royalties and up to $852.6 million in potential milestones across nine development-stage assets, including osavampator, which is being evaluated in Phase 3 studies for major depressive disorder; volixibat, which is being evaluated in PSC and PBC; OHB-607, which Oak Hill Bio Ltd and its partner are developing for the prevention of bronchopulmonary dysplasia in extremely premature infants; REC-4881, which is in Phase 2 development for familial adenomatous polyposis; and five early-stage Oak Hill Bio assets

•

Prior to amending the collaboration, XOMA held a mid-single digit royalty and $16.25 million in potential milestones associated with mezagitamab

•

Following the transaction, XOMA will retain a low single-digit royalty entitlement on mezagitamab and up to $13.0 million in milestones

Company Acquisitions
•

Completed or served as the structuring agent in the acquisition of seven companies since the beginning of 2025

•

Accumulated non-dilutive capital of $11.7 million, net of transaction expenses

•

Obtained economic interests of approximately 25% in up to $1.1 billion of potential milestone payments and low to mid-single-digit royalties from eight partnered assets

•

Eligible for 25-70% of proceeds related to any future out license or sale of legacy assets or platform technology from these companies, including the ctLNP delivery platform from Generation Bio

Fourth Quarter and Full-Year 2025 Financial Results

In the fourth quarter of 2025, XOMA Royalty received $3.2 million in cash receipts from royalties and commercial payments and $3.3 million in milestone payments and paid $1.4 million in dividends on the XOMA Royalty Perpetual Preferred stocks. For the full year of 2025, XOMA Royalty received $50.5 million in cash receipts, including $33.6 million in royalties and commercial payments and $16.9 million in milestone payments and fees. During 2025, XOMA Royalty deployed $25.0 million to acquire additional assets for its royalty and milestone portfolio, repurchased 648,048 shares of its common stock for a cost of $16.0 million, and paid $5.5 million in dividends on the XOMA Royalty Perpetual Preferred stocks.

Income and Revenue: Income and revenues for the three months ended December 31, 2025 and 2024, were $13.8 million and $8.7 million, respectively. Income and revenues for the years ended December 31, 2025 and 2024, were $52.1 million and $28.5 million, respectively. The increase in both periods was primarily driven by increased income related to VABYSMO (faricimab-svoa) and OJEMDA (tovorafenib) and milestone payments received from Rezolute and Takeda.

(Press release, Xoma, MAR 18, 2026, View Source [SID1234663757])

On March 18, 2026 Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") reported that the administration of the anticancer agent EZH2 inhibitor "Tazverik Tablets 200 mg" (generic name: tazemetostat hydrobromide), which is manufactured and marketed in Japan by Eisai should be discontinued. We plan to discontinue sales of this product once we have confirmed that it is no longer being administered to any patients.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Following the announced voluntarily withdrawal of this product in the United States and other countries, Eisai has been collecting and reviewing safety data, including from the overseas clinical trials including SYMPHONY-1*1 and postmarketing data both domestic and from overseas. Based on the review of the available safety data, multiple cases of secondary hematologic malignancies have occurred on both combination and monotherapy treatment with tazemetostat.

After a comprehensive evaluation of these findings, we concluded that it is necessary to give the fullest possible consideration to the risk of secondary hematologic malignancies occurring even under the approved conditions of use in Japan.

Prioritizing patient safety, we are communicating with medical institutions in Japan where the drug is prescribed to consider discontinuing Tazverik immediately for patients currently receiving it, and to refrain from initiating any new administration.

Eisai will continue to make every effort to provide timely and appropriate information to healthcare professionals to prevent any confusion or disruption for medical institutions or patients.

(Press release, Eisai, MAR 18, 2026, View Source [SID1234663699])