On December 15, 2021 NOXXON Pharma N.V. (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that Aram Mangasarian, CEO of NOXXON, and Bryan Jennings, CFO of NOXXON, will participate and be available for meetings at several banking and investor conferences in early 2022 (Press release, NOXXON, DEC 15, 2021, View Source [SID1234597233]).

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LifeSci Partners Corporate Access Event, January 5-7, 2022, digital event
Corporate Access Event organized by LifeSci Partners will feature more than 200 innovative publicly traded and privately held biotechnology, medical technology, pharmaceutical, life sciences, and digital health companies from across the globe. The event will include one-on-one meetings with company senior management teams and panel discussions featuring KOLs, CEOs, specialized investors, and healthcare experts highlighting the most relevant topics impacting the life sciences industry today. The NOXXON team will be available for meetings. Registration for the event is required.

H.C. Wainwright BIOCONNECT Virtual Conference, January 10-13, 2022, digital event
BIOCONNECT hosted by H.C. Wainwright aims to connect life sciences companies with a diverse roster of investors. NOXXON’s corporate video presentation will be available on demand from January 10 at 7:00 a.m. ET. The team welcomes meetings with the investment community during the conference. Registration for the event is required.

BIOMED EVENT 2022, January 26, 2022, Paris, France
The 7th edition of the BIOMED EVENT organized by INVEST SECURITIES, will host numerous European listed biotech/medtech companies and institutional investors. NOXXON’s CEO will be available for one-on-one and group meetings throughout the day. Registration for the event is required.

LSX World Congress, February 8-9, 2022, London, UK or February 14-25, 2022, digital event
The 8th LSX World Congress will gather the founders and CEOs of innovative start-ups through to big pharma and aims to provide platform for companies to share their cutting-edge research and technology. The Congress offers one-on-one partnering, connecting the biotech, healthtech and medtech industry c-suite with the sector’s most active investors, pharma and health technology BD&L teams, R&D leaders, KOLs and top tier service companies who are driving the sector forward. NOXXON’s in-person or virtual participation will be driven by the conditions imposed by the pandemic. More information about the event can be found here.

On December 15, 2021 Immix Biopharma, Inc. (Nasdaq: IMMX) ("ImmixBio" or the "Company"), a biopharmaceutical company pioneering Tissue Specific Therapeutics (TSTx)TM targeting oncology and immuno-dysregulated diseases, reported the pricing of its initial public offering of 4,200,000 shares of its common stock at a public offering price of $5.00 per share, for gross proceeds of $21,000,000 before deducting underwriting discounts, commissions and offering expenses (Press release, Immix Biopharma, DEC 15, 2021, View Source [SID1234597262]). In addition, ImmixBio has granted the underwriters a 45-day option to purchase up to an additional 630,000 shares of common stock solely to cover over-allotments. The shares of common stock are expected to begin trading on the Nasdaq Capital Market under the ticker symbol "IMMX" on December 16, 2021. The offering is expected to close on December 20, 2021, subject to satisfaction of customary closing conditions.

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The net proceeds from the initial public offering will be used to fund a planned IMX-110 Phase 2a clinical trial in soft tissue sarcoma and IMX-110 + tislelizumab Phase 1b combination trial, for IND-enabling studies for IMX-111 (colorectal cancer) and IMX-120 (inflammatory bowel disease), and for working capital and other general corporate purposes.

ThinkEquity is acting as the sole book-running manager for the offering.

The registration statement on Form S-1 (file No. 333-259591) relating to the shares being sold in this offering has been filed with the U.S. Securities and Exchange Commission and became effective on December 15, 2021. A final prospectus related to the proposed offering will be filed and made available on the SEC’s website at View Source The offering is being made only by means of a prospectus. Electronic copies of the final prospectus may be obtained, when available, from ThinkEquity, 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673 and by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On December 15, 2021 Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) reported preclinical data demonstrating the synergistic anti-leukemic effects of pelareorep combined with the chemotherapeutic agent azacitidine (Press release, Oncolytics Biotech, DEC 15, 2021, View Source [SID1234597204]). The data were featured in a poster presentation at the 2021 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, which took place from December 11-14, 2021, in Atlanta, Georgia.

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Preclinical studies featured in the poster evaluated pelareorep in combination with azacitidine in acute myeloid leukemia (AML) cells in vitro and in a leukemia xenograft mouse model. Key data and conclusions from the poster include:

•Compared to either treatment alone, treatment with pelareorep plus azacitidine led to a statistically significant reduction (p<0.01) in tumor burden in a leukemia xenograft mouse model

•Compared to either treatment alone, treatment with pelareorep plus azacitidine led to a statistically significant (p<0.001) synergistic enhancement of anti-leukemic activity against AML cell lines, a benefit that was confirmed in AML patient samples in vitro

•The combination of pelareorep and azacitidine dramatically upregulated multiple genes known to drive anti-cancer immune responses such as IFNβ1, BATF2, IL-12β, CCL2, TLR3, and PD-L1

"These compelling preclinical findings, together with previously reported data demonstrating clinical proof-of-concept in multiple myeloma, indicate that pelareorep’s immunotherapeutic effects extend across multiple hematological malignancies. They also further highlight pelareorep’s potential to enhance the efficacy of a wide range of cancer therapeutics and have stimulated interest in investigator-sponsored clinical studies of pelareorep in leukemia," said Thomas Heineman, M.D., Ph.D., Global Head of Clinical Development and Operations at Oncolytics. "Given its ability to be administered intravenously without special handling procedures, pelareorep exerts a systemic effect that is uniquely suited to address liquid tumors compared to other oncolytic viruses. We look forward to leveraging collaborative relationships to continue evaluating pelareorep in hematological malignancies, which will allow us to potentially broaden its therapeutic impact while maintaining our primary focus on our lead breast cancer program."

A copy of the ASH (Free ASH Whitepaper) poster titled, "The Clinical Oncolytic Reovirus Formulation Reolysin Synergistically Augments the Anti-Leukemic Activity of Azacitidine," is available on the Posters & Publications page of Oncolytics’ website (LINK).

On December 15, 2021 Mythic Therapeutics reported its launch to develop smarter and safer antibody-drug conjugates (ADCs) with an oversubscribed Series B financing round of $103 million (Press release, Mythic Therapeutics, DEC 15, 2021, View Source [SID1234597235]). Viking Global Investors led the round, along with new investors including Venrock Healthcare Capital Partners, Foresite Capital, Perceptive Advisors, and Highside Capital. Existing Mythic investors participating in the round include Venrock, First Round Capital, OMX Ventures, Lifeforce Capital, and Refactor Capital. The proceeds from Mythic’s Series B will finance the lead program through first-in-human clinical studies in lung cancer and fund pipeline development.

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"We are thrilled to partner with this distinguished group of investors," said Alex Nichols, PhD, co-founder, President, and CEO of Mythic Therapeutics. "This financing validates the FateControl approach and supports our efforts to achieve expanded use of Mythic’s ADCs within and across indications, translating to improved outcomes for patients with unmet medical needs."

Although the development history of ADCs spans more than four decades, the clinical benefit of ADCs has so far remained limited to a subset of diseases and targets with optimal biological characteristics, such as high levels of target expression. Mythic has developed a breakthrough approach to expand the role of ADCs in precision medicine by dramatically improving ADC therapeutic index against a broad set of molecular targets and patient profiles.

"To date, approaches to improve the performance of ADCs have focused primarily on innovation in one of three dimensions: linker and payload chemistries, conjugation technology, and new target biology," said Brian Fiske, PhD, co-founder and Chief Scientific Officer of Mythic Therapeutics. "Mythic seeks to improve the clinical performance of ADCs by introducing a new dimension of ADC technology focused on manipulating the fate of ADCs within the cell."

ADCs are designed to specifically deliver a therapeutic payload to a target tissue or disease site. However, studies have demonstrated that the vast majority of payload is ultimately released non-specifically throughout the body, causing systemic toxicity and reducing efficacy. Mythic’s FateControl technology increases the amount of ADC that is internalized by the target tissue while reducing payload release in non-targeted tissues, thereby improving therapeutic index independent of the linker and payload. Mythic’s lead program in lung cancer has the potential to drive a multi-fold expansion of the number of lung cancer patients eligible for treatment using ADCs; the company plans on developing a pipeline of products incorporating its platform technology.

"Venrock was attracted by Mythic’s innovative strategy to overcome one of the most historically challenging obstacles to realizing the full potential of ADCs for patients," said Bryan Roberts of Venrock, a member of Mythic’s Board of Directors. "The progress this team has made in a short time reinforces our deep conviction in Mythic’s ability to develop a pipeline of safer and more effective ADCs, beginning with their lead program. We are delighted to be part of the Mythic story."

Leadership

Alex Nichols, PhD, Co-Founder, President, CEO, and Director
Brian Fiske, PhD, Co-Founder, Chief Scientific Officer, and Director
Sandra Poole, MASc, PEng, Chief Operating Officer
In addition to Alex and Brian, the Mythic Therapeutics Board of Directors is comprised of:

Bryan Roberts, PhD, Partner, Venrock
Josh Kopelman, Partner, First Round Capital
Peter Hecht, PhD, Co-Founder and CEO, Cyclerion; Co-Founder and former CEO, Ironwood Pharmaceuticals
Scientific Advisory Board

Douglas E. Williams, PhD, President and CEO, Codiak Biosciences
John Lambert, PhD, former EVP and CSO, ImmunoGen
Michael Vasconcelles, MD, Chief Medical Officer, Flatiron Health
Richard Gregory, PhD, former CSO, ImmunoGen and former head of R&D, Sanofi
Scott J. Dylla, PhD, Co-Founder and Former CSO, Stemcentrx

On December 15, 2021 Helix BioPharma Corp. (TSX: "HBP"), ("Helix" or the "Company"), a clinical-stage biopharmaceutical company developing unique therapies in the field of immuno-oncology based on its proprietary technological platform DOS47, reported fiscal 2022 first quarter results for the period ending October 31, 2021 (Press release, Helix BioPharma, DEC 15, 2021, View Source [SID1234597368]).

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OVERVIEW
The Company reported a net loss and total comprehensive loss for the three-month period ended October 31, 2021, of $1,813,000 (2020-$222,000). Net loss and comprehensive loss for the three-month period ending October 31, 2020, included a gain from loss of control in Helix Immuno-Oncology S.A. ("HIO") of $2,162,000. Clinical development

 Phase I combination therapy study in lung cancer (LDOS001):
 Final clinical study report expected to be completed by the end of December 2021;
 Phase II combination therapy trial in lung cancer (LDOS003):  Final clinical study report expected to be completed in March 2022 provided the Company settles a contractual disagreement with the clinical research organization engaged to oversee the study.

 The Company ceased patient enrolment into the trial in 2020 and proceeded to data analysis.  As previously announced, the Company will not be advancing the randomized portion of the study without third-party partner funding. To date, no third-party partner has been identified.  Phase Ib/II combination trial in pancreatic cancer (LDSOS006):  On November 15, 2021, the Company applied for a revision to the clinical protocol to the U.S. Food and Drug Administration ("FDA").

 L-DOS47 immunotherapy chemo combination study in lung cancer:  The Company engaged key opinion leaders on the feasibility and design of a possible immunotherapy chemo combination clinical study. The Company is not currently in a position to make a submission to the FDA regarding the potential clinical study.  Clinical drug product strategic review:  The Company hired biotechnology consults to assess the Company’s drug product candidate with a focus on identifying value propositions and positioning strategies that would enable clinical adoption of L-DOS47. This engagement includes input from key opinion leaders on the positioning of possible combination therapies and the prioritization of current and/or any additional clinical indications. The Company expects the consulting firm’s report to be finalized by the end of December 2021. Corporate development

 On August 19, 2021, the Company announced that Dr. Krzysztof Saczek had been appointed as a member of the board of directors of the Company (the "Board") effective immediately in connection with the resignation of Dr. Heman Chao as CEO, CSO and as a member of the Board. Mr. Chao’s resignation became effective on September 1, 2021 and assumed the position of Chair of the Company’s Scientific Advisory Board on the same date.

1  On September 20, 2021, the Company announced the appointment of the company’s Chairman, Dr. Slawomir Majewski, as Interim Chief Executive Officer to hold office while the Board worked to identify and evaluate potential candidates as permanent CEO. Research and development Research & development expenses for the three-month period ended October 31, 2021, totalled $1,249,000 (2020 – $1,084,000). Research and development expenditures in the three-month period ended October 31, 2021, when compared to the three-month period ended October 31, 2020, were higher by $165,000.

The increase is mainly the result of higher third-party research and development consulting services of $163,000 in addition to higher contact manufacturing services of $267,000 which were offset by lower clinical operations spend of $213,000. The Company hired biotechnology consults to assess the Company’s drug product candidate with a focus on identifying value propositions and positioning strategies that would enable clinical adoption of L-DOS47. This engagement includes broad clinical development key opinion leader input on the positioning of possible combination therapies and the prioritization of current and/or any additional clinical indications. The Company expects the consulting firm’s report to be finalized by the end of December 2021. The increase in manufacturing spend is the result of new production lot of Polysorbate 80 and increased stability and assay activity from recently repolished old drug substance and lyophilization of new drug product. Lower clinical operations spend is mainly the result of analytical method development spend incurred in the comparative prior year’s quarter related to LDOS006, the Company’s Phase Ib/II combination trial for pancreatic cancer. Operating, general and administration Operating, general and administration expenses for the three-month period ended October 31, 2021, totalled $447,000 (2020-$1,303,000).

Operating, general and administration expenditures in the three-month period ended October 31, 2021, when compared to the three-month period ended October 31, 2020, were lower by $856,000. The decrease is mainly the result of expenses associated with various third-party advisory services such as legal, accounting and investment banking of $210,00 incurred in the comparative prior year’s quarter related to the Company’s attempt to raise additional capital as part of a qualifying transaction to list on the Nasdaq; lower investor relations spend of $287,000 as a result of the termination of the agreement on October 21, 2020 the Company had in place with ACM Alpha Consulting Management EST ("ACMest"); and lower stock-based compensation expense of options granted to directors of the Company over their vesting period of $355,000.

2 LIQUIDITY AND CAPITAL RESOURCES
The Company reported a net loss and total comprehensive loss for the three-month period ended October 31, 2021, of $1,813,000 (2020-$222,000). As at October 31, 2021 the Company had working capital deficiency of $1,493,000, shareholders’ deficiency of $2,730,000 and a deficit of $190,367,000. As at July 31, 2021, the Company had working capital of $144,000, shareholders’ deficiency of $1,393,000, a deficit of $188,554,000. In order for the Company to advance the currently planned preclinical and clinical research and development activities, its collaborative scientific research programs and pay for its overhead costs, the Company will need to raise approximately $15,000,000 through to the end of fiscal 2023.

The Company’s cash reserves of $1,873,000 as at October 31, 2021 are insufficient to meet anticipated cash needs for working capital and capital expenditures through the next twelve months, nor are they sufficient to see planned research and development initiatives through to completion. To the extent that the Company does not believe it has sufficient liquidity to meet its current obligations, management considers securing additional funds, preferably through the issuance of equity securities of the Company, to be critical for its development needs. The Company may also consider other forms of raising funds, such as the issuance of debt which may or may not include a conversion of equity in the Company. The Company’s long-term liquidity depends on its ability to raise funds from various sources, which depends substantially on the success of its ongoing research and development programs, economic conditions and the state of the biotech industry