Cardinal Health expands solutions to mitigate missed cancer screenings

On October 25, 2021 Cardinal Health (NYSE: CAH) reported its cancer screening offerings from FUJIFILM Healthcare Americas Corporation and Polymedco that can be done either outside of a doctor’s office or with less invasive procedures can help combat the increase in cancer-related deaths due to late-stage diagnoses1 from pandemic-related delays (Press release, Cardinal Health, OCT 25, 2021, View Source [SID1234591892]).

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Cardinal Health, Inc. is a global, integrated healthcare services and products company, providing customized solutions for hospitals, healthcare systems, pharmacies, ambulatory surgery centers, clinical laboratories and physician offices worldwide. (PRNewsfoto/Cardinal Health)

"The pandemic has changed the landscape of traditional diagnostic methods and is driving the healthcare industry to evaluate screenings differently," added Chris Kerski, general manager and senior vice president of Cardinal Health Laboratory Products. "We’re adding new testing solutions to our portfolio to reduce barriers to screening and support patient-led cancer screenings."

Colon Cancer

According to a report in JAMA Oncology2, nearly 10 million cancer screenings for breast, colon and prostate cancer were missed in the U.S. since the pandemic began. Researchers recently reported a more than 40% decline in colon cancer diagnoses alone during the pandemic, a statistic that points to missed screenings, not fewer cases3.

"A missed screening increases the likelihood of a late-stage cancer diagnosis, which is associated with poor prognosis," says Nicholas Sullivan, Ph.D., a senior product manager at Cardinal Health Laboratory Products with a background in cancer biology and clinical laboratory medicine. "This high number of missed screenings during the pandemic has the potential to impact cancer patient outcomes for years."

During the pandemic, some health systems and health plans began proactively mailing screening collection kits to patients, rather than waiting for patients to come in for a routine visit or colonoscopy4. Cardinal Health works with Polymedco to offer OC-AutoFIT, which detects small amounts of blood in stool – an early indication of colon cancer5. Different than a colonoscopy, patients don’t have to prep in advance of the test and can do the stool specimen collection at home.

Liver Cancer

Liver cancer is one of the top-three leading causes of cancer-related deaths worldwide6 accounting for more than 700,000 deaths each year7.

In November 2020, Cardinal Health became the first distributor of Fujifilm’s innovative solution, the µTASWako i30 Immunoanalyzer System testing for liver biomarkers AFP-L3 and DCP using a simple blood draw. These biomarkers aid in the risk assessment of patients with chronic liver disease for the development of hepatocellular carcinoma (HCC), the most common type of liver cancer8.

HCC surveillance is critical for those at-risk for liver cancer given its lethality. A recent study9 reported that liver cancer surveillance dramatically declined during the pandemic and that "a delay of just a few months in HCC surveillance may be catastrophic for patients, given that the doubling time for HCC tumor volume is 85.7 days." Only 20% of those patients at risk of developing liver cancer receive surveillance10.

Cardinal Health now offers Fujifilm’s automated solution to enhance clinical lab customers’ liver surveillance cancer programs.

Cancer screening access

As a trusted advisor to the clinical laboratory market, Cardinal Health advocates for the important role diagnostic testing plays in improving healthcare.

"These critical expansions of our cancer screening offerings, coupled with our robust anatomic pathology and laboratory kitting services, underscore our commitment to making healthcare more accessible for patients. We must stay vigilant in preventative care through the utilization of easy-to-access screening tools and draw more awareness to the secondary impacts of the pandemic," says Kerski.

OncoNano Announces $18.4 Million Equity Investment by the Cancer Prevention and Research Institute of Texas

On October 25, 2021 OncoNano Medicine, Inc. reported that the Cancer Prevention and Research Institute of Texas (CPRIT) will convert $18.4 million in grant award funding into an equity investment in OncoNano (Press release, OncoNano Medicine, OCT 25, 2021, View Source [SID1234591908]). Proceeds of the financing will be used to support OncoNano’s Phase 3 clinical trials in the U.S. and Europe for pegsitacianine, an innovative real-time imaging agent used in intraoperative surgical resection of solid tumors, and accelerate the advancement of the company’s first internal therapeutic development program, ONM-501, a novel immune-therapeutic formulated with the company’s core delivery technology. This conversion will close OncoNano’s Series B financing round with $68.4 million in total committed capital.

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CPRIT awarded OncoNano with a grant totaling $15.4 million in 2019 to advance the company’s differentiated STING (STimulator of INterferon Genes) agonist development candidate, ONM-501, and provided a $9.97 million grant in 2020 to advance pegsitacianine, the company’s IV fluorescent nanoprobe for use in image-guided cancer surgeries. After this investment, OncoNano will still have $6.97 million of the 2020 grant available to advance the use of pegsitacianine in the visualization and resection of metastatic disease.

"CPRIT has played a crucial role in the establishment and advancement of the expanding life sciences research community in Texas. We are thrilled to continue our close partnership with CPRIT and welcome them as shareholders in OncoNano through this conversion of earlier grant awards to an equity investment in our over-subscribed Series B financing," said Martin Driscoll, CEO at OncoNano Medicine, Inc. "With the continued support of our investors, including this infusion of new capital from CPRIT, we can accelerate the development of our novel programs and expand our operations in North Texas. Our successful Series B financing will be instrumental in advancing pegsitacianine into a pivotal trial program in the U.S. and Europe and advance ONM-501 to a first in human trial in early 2023. We look forward to working together with CPRIT and our partners to bring important new interventions and treatments to cancer patients in need."

"CPRIT supported the initial research in Dr. Gao’s laboratory at The University of Texas Southwestern Medical Center that led to the therapies OncoNano Medicine is commercially developing today," said Wayne Roberts, CEO, CPRIT. "We’re thrilled to see the company translating that groundbreaking research into products to improve cancer patient care. With the additional equity investment in OncoNano Medicine, CPRIT helps secure Texas’ investment in, and ability to benefit from, this technology and the potential therapies it could produce."

Bristol Myers Squibb Announces Earnings Call Time Change; Third Quarter 2021 Earnings Call to Occur on October 27, 2021 at 10 a.m. (Eastern Time)

On October 25, 2021 Bristol Myers Squibb (NYSE:BMY) reported that it has changed the timing of its previously announced earnings conference call (Press release, Bristol-Myers Squibb, OCT 25, 2021, View Source [SID1234591874]). The Company will now host a conference call to discuss results for the third quarter of 2021 on Wednesday, October 27, 2021 at 10:00 a.m. ET . During the call, company executives will review financial results and address inquiries from investors and analysts.

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Investors and the general public are invited to listen to a live webcast of the call at View Source or by using this link which becomes active 15 minutes prior to the scheduled start time and entering your information to be connected. Investors and the general public can also access the live webcast by dialing in the U.S. toll free 800-263-0877 or international +1 313-209-7315, confirmation code: 8911662. Materials related to the call will be available at the same website prior to the conference call.

A replay of the call will be available on View Source or by dialing in the U.S. toll free 888-203-1112 or international +1 719-457-0820, confirmation code: 8911662. The replay will be available beginning at 1:30 p.m. ET on October 27 through 1:30 p.m. ET on November 10, 2021.

Castle Biosciences to Release Third Quarter 2021 Financial Results and Host Conference Call on Monday, Nov. 8, 2021

On October 25, 2021 Castle Biosciences, Inc. (Nasdaq: CSTL), a company applying innovative diagnostics to inform disease management decisions and improve patient outcomes, reported that it will release its financial results for the third quarter and nine months ended Sept. 30, 2021, after the close of market on Monday, Nov. 8, 2021 (Press release, Castle Biosciences, OCT 25, 2021, View Source [SID1234591909]).

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Company management will host a conference call and webcast to discuss its financial results at 4:30 p.m. Eastern time on the same day.

Conference Call and Webcast Details

A live webcast of the conference call can be accessed here: View Source or via the webcast link on the Investor Relations page of the Company’s website, View Source Please access the webcast at least 10 minutes before the conference call start time. An archive of the webcast will be available on the Company’s website until Nov. 30, 2021.

To access the live conference call via phone, please dial 844 200 6205 from the United States, or +1 929 526 1599 internationally, at least 10 minutes prior to the start of the call, using the conference ID 256168.

There will be a brief Question & Answer session following management commentary.

Evotec provides preliminary nine month financial results

On October 25, 2021 Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809), reported preliminary and unaudited results for the first nine months ended 30 September 2021 (Press release, Evotec, OCT 25, 2021, View Source;announcements/press-releases/p/evotec-provides-preliminary-nine-month-financial-results-6104 [SID1234591925]).

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Evotec expects revenues from contracts with customers for the first nine months of 2021 to be in the range of € 425 – 435 m; significantly above the € 360.4 m posted in the prior year’s period. Like-for-like growth (excluding Sanofi payments of € 8.6 m in Q1 2020 and negative fx-effects) is expected to be in the range of 24 – 27%
Adjusted Group EBITDA for the first nine months of 2021 is expected to reach € 68 – 72 m, compared to € 76.9 m as of 30 September 2020, affected primarily by planned capacity build-up ahead of imminent production start of J.POD 1 US, Redmond. Like-for-like growth (adjusting for Sanofi and negative fx-effects) is expected to be within a range of 12 – 18%
Evotec expects unpartnered R&D expenses in the period to be between € 41 – 44 m, between € 8 – 11 m higher than in 9M 2020
The expected financial results discussed in this press release are based upon information available to Evotec as of the date hereof. This data is not a comprehensive statement of the Company’s financial results for the nine months ended 30 September 2021, and the closing process and related auditor review have not been completed. During the preparation of Evotec’s comprehensive financial statements adjustments to the preliminary estimated financial information presented herein may be identified, and such changes could be material. There can be no assurance that these estimates will be realised, and these estimates are subject to risks and uncertainties, many of which are not within the Company’s control. The timing of this disclosure is unique to this quarter given the timing of the Company’s application to list on the Nasdaq Global Select Market, and it does not intend to report preliminary results in future quarters. Evotec will issue complete financial results in connection with its 9M conference call on 11 November 2021.