CytomX Therapeutics to Announce Third Quarter 2021 Financial Results on November 4, 2021

On October 28, 2021 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a clinical-stage oncology-focused biopharmaceutical company pioneering a novel class of investigational conditionally activated therapeutics based on its Probody technology platform, reported that it will report third quarter 2021 financial results on Thursday, November 4, 2021, after the close of U.S. markets (Press release, CytomX Therapeutics, OCT 28, 2021, View Source [SID1234592078]). Following the announcement, the Company will host a conference call and webcast at 5:00 p.m. ET / 2:00 p.m. PT to discuss the results and provide a corporate update.

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Participants may access the live webcast of the conference call from the Events and Presentations page of CytomX’s website at View Source An archived replay of the webcast will be available on the Company’s website until November 11, 2021.

Frazier Healthcare Partners Closes Oversubscribed $830 Million Life Sciences Public Fund

On October 28, 2021 Frazier Healthcare Partners reported the closing of Frazier Life Sciences Public Fund, L.P., exceeding its target and closing on nearly $830 million in capital commitments in an oversubscribed fundraise (Press release, Frazier Healthcare, OCT 28, 2021, View Source [SID1234592098]).

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Led by Managing Partner Albert Cha, General Partner and Portfolio Manager Jamie Brush, and Managing Partners Patrick Heron and James Topper, Frazier Life Sciences Public Fund is a long-only fund investing in small- and mid-cap public biotech companies. Frazier Life Sciences Public Fund marks Frazier’s first dedicated public life sciences fund, bringing the firm’s total committed capital raised since inception to over $7.1 billion.

"We are thrilled to announce the launch of our public life sciences fund," stated Albert Cha, managing partner on the Frazier Life Sciences team. "We are extremely grateful to our limited partners for their support."

Recent exits of Frazier Life Sciences public investments include ARMO BioSciences (acquired by Eli Lilly), Ignyta (acquired by Roche), Rocket Pharmaceuticals (NASDAQ: RCKT), Translate Bio (NASDAQ: TBIO, acquired by Sanofi), and Trillium Therapeutics (NASDAQ: TRIL, pending acquisition by Pfizer).

PASCAL BIOSCIENCES ANNOUNCES FINANCING

On October 28, 2021 Pascal Biosciences Inc. ("Pascal" or the "Company") (TSXV: PAS) (OTC: PSCBF) (FSE: 6PB-FF) reported the following actions to continue the development of the Company’s PAS-403 and PAS-393 patented molecules for development of cancer therapeutics prior to commencing clinical trials and for general working capital to support this direction (Press release, Pascal Biosciences, OCT 28, 2021, View Source [SID1234592115]).

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The Company announces a non-brokered private placement financing of up to 9,000,000 units (each a "Unit") of securities at a price of $0.10 per Unit for aggregate gross proceeds of up to $900,000.00 (the "Offering"). Each Unit will be comprised of one (1) common share and one (1) non-transferable common share purchase warrant, with each whole warrant entitling the holder to purchase one additional common share at a price of $0.15 for two years from the closing date of the private placement. The exercise term of the warrant will be accelerated in the event the closing price of the Shares is above $0.20 for ten consecutive days and will be exercisable for a period of 15 days from the date of receipt by investors of a Notice of Acceleration. Finder’s fees of up to 10% may be paid.

All securities issued will be subject to a four month holding period which will expire on the date that is four months and one day from the date of issue.

Takeda Announces Acquisition of Own Shares

On October 28, 2021 Takeda Pharmaceutical Company Limited (TOKYO:4502/NYSE:TAK) ("Takeda") reported that its Board of Directors resolved today to engage in the acquisition of its own shares pursuant to the provision of its Articles of Incorporation in accordance with Article 459, paragraph 1 of the Companies Act of Japan, as detailed below (Press release, Takeda, OCT 28, 2021, View Source [SID1234592132]).

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"At our current share price, we see an opportunity to buy back our shares at a substantial discount to what we perceive is their underlying value," said Costa Saroukos, director and Chief Financial Officer of Takeda. "We expect that this share buyback of up to 100B yen will not impact our deleveraging plans, and that we will remain firmly on track to deliver on our target for 2x (‘low twos’) net debt to Adjusted EBITDA by the end of FY23. We are also maintaining our existing dividend policy and updating our capital allocation policy to allow for share buybacks in the future when appropriate. This underscores our business’ strong cash generation ability, our confidence in our fundamental growth driven by the 14 global brands, and our belief that the R&D strategy with ~40 new molecular entities in the pipeline, will deliver for the long term."

This buyback of shares will be funded by Takeda’s operating cash flow driven by growth in our 14 global brands and working capital improvements.

1. Reason for acquisition of its own shares

To enhance capital efficiency and improve shareholder returns.

2. Details of acquisition

(1) Class of shares to be acquired:

Shares of common stock

(2) Number of shares to be acquired:

Up to 35 million shares

(equivalent to 2.23% of the total number of shares outstanding excluding treasury shares)

(3) Total amount of shares to be acquired:

Up to JPY 100 billion

(4) Schedule of acquisition:

From November 2, 2021 to April 29, 2022

(5) Method of acquisition:

Open-market repurchase through a trust bank

(Reference)

Treasury shares held by Takeda as of September 30, 2021
Aggregate number of issued shares (excluding treasury shares)

1,572,829,854 shares

Number of treasury shares

9,422,671 shares

Updated Capital Allocation Policy

Takeda is delivering on its financial commitments and has a strong cash flow outlook driven by business momentum, cost synergies, and non-core asset divestitures. Guided by our values and our commitment to Patients, People and Planet, we will allocate capital to maximize value for patients and shareholders.

Takeda’s policy in the allocation of capital is as follows:

• Invest in growth drivers;
• Deleverage rapidly; and
• Shareholder returns.

In respect of "Invest in growth drivers", Takeda makes disciplined and focused investments in value-creating business opportunities including R&D, new product launches, including in China, and plasma-derived therapies. With regards to "Deleverage rapidly", Takeda is targeting a 2x (i.e. "low-twos") net debt/adjusted EBITDA ratio within fiscal years ending March 2022 – March 2024 and has committed to maintaining solid investment grade credit ratings. In respect of "Shareholder returns", Takeda maintains its well-established dividend policy of 180 yen per share annually, alongside share buybacks when appropriate. We expect underlying growth momentum to continue over the mid-term.

Agilent Companion Diagnostic Expands CE-IVD Mark in Europe to Include Triple-Negative Breast Cancer (TNBC)

On October 28, 2021 Agilent Technologies Inc. (NYSE: A) reported that its PD-L1 IHC 22C3 pharmDx assay is now labelled for use in TNBC in the European Union (Press release, Agilent, OCT 28, 2021, View Source [SID1234592148]).

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"Anti-PD-1 therapies like KEYTRUDA continue to offer new treatment options for cancer patients"

PD-L1 expression is a critical biomarker for response to anti-PD-1 therapies such as KEYTRUDA (pembrolizumab), an anti-PD-1 therapy manufactured by Merck (known as MSD outside the United States and Canada). The expanded use of PD-L1 IHC 22C3 pharmDx strengthens the ability of pathologists to identify patients who may be eligible for treatment with KEYTRUDA. In Europe, KEYTRUDA, in combination with chemotherapy, is indicated for the treatment of locally recurrent unresectable or metastatic TNBC in adults whose tumors express PD-L1 [Combined Positive Score (CPS) ≥ 10] and who have not received prior chemotherapy for metastatic disease.1

PD-L1 IHC 22C3 pharmDx is the only clinical trial proven PD-L1 assay CE-IVD–marked as an aid in identifying TNBC patients for treatment with KEYTRUDA. PD-L1 IHC 22C3 pharmDx now helps physicians in Europe identify patients for treatment with KEYTRUDA in five cancer types: non-small cell lung cancer (NSCLC), urothelial carcinoma, head and neck squamous cell carcinoma (HNSCC), esophageal cancer and triple-negative breast cancer (TNBC).2

"Anti-PD-1 therapies like KEYTRUDA continue to offer new treatment options for cancer patients," said Sam Raha, president of Agilent’s Diagnostics and Genomics Group. "This indication expansion of PD-L1 IHC 22C3 pharmDx in TNBC will allow physicians in Europe access to critical information to qualify even more patients who could benefit from these treatments. This further demonstrates Agilent’s role as a leader in developing companion diagnostics for targeted therapies."

Breast cancer is the most common type of cancer among women, with more than 530,000 new cases diagnosed in Europe in 2020.3 Approximately 15-20% of breast cancer diagnoses are TNBC.4

KEYTRUDA is a humanized monoclonal antibody that enhances the ability of the immune system to detect and fight tumor cells. KEYTRUDA blocks the PD-1 pathway, thereby activating T-lymphocytes that may affect both tumor cells and healthy cells.1 KEYTRUDA and other targeted immunotherapies are changing cancer treatment, and their therapeutic value is being realized across a growing list of cancer types. PD-L1 IHC 22C3 pharmDx was developed by Agilent as a companion diagnostic for KEYTRUDA in partnership with Merck.