On November 9, 2021 Asgard Therapeutics AB ("Asgard"), a private biotech company pioneering in vivo cell reprogramming approaches to elicit potent anti-cancer immune responses, reported the completion of a EUR 6 million seed financing round (Press release, Asgard Therapeutics, NOV 9, 2021, View Source [SID1234594891]). The financing was co-led by Novo Holdings, Boehringer Ingelheim Venture Fund and Industrifonden.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Asgard is developing a paradigm-shifting cancer immunotherapy approach, based on its proprietary TrojanDC technology, to reinstate cancer immunogenicity. TrojanDC is a gene therapy that reprograms cancer cells into type-1 conventional dendritic cells, allowing the presentation of their own antigens to the immune system, thereby eliciting potent anti-cancer immune responses. Designed as an off-the-shelf gene therapy, TrojanDC induces a personalized immune response, and overcomes many of the logistic and manufacturing hurdles of conventional cell-based therapies.

The Company originated from Lund University’s Cell Reprogramming and Immunity lab, led by Professor Filipe Pereira PhD, who is also Asgard’s Co-Founder and Head of Innovation. Cristiana Pires PhD and Fábio Rosa PhD established the seminal work describing direct reprogramming of somatic cells published in the prestigious science journal Science Immunology .

Cristiana Pires, PhD, Co-Founder and Chief Executive Officer of Asgard Therapeutics, said: "At Asgard, we are committed to surpassing the challenges of current cancer immunotherapies, making them available for every patient. The support we have received from such a strong syndicate of life science investors, is a strong endorsement to the potential of our TrojanDC technology. The financing will enable us to expand our pipeline of preclinical assets and build on our commitment to making personalized cancer immunotherapies optimized to each unique patient."

João Ribas from Novo Seeds commented: "We are very pleased to co-lead this financing and support the translation of the founders’ scientific research at Lund University. While reprogramming approaches have been mainly restricted to regenerative medicine, the work of Filipe, Cristiana and their team opens exciting opportunities to merge the fields of cell reprogramming and cancer immunotherapy that can be applied to several cancers, representing a platform technology with enormous potential. We look forward to working with the Asgard team as they pioneer a new generation of cancer immunotherapy".

Philipp Müller from Boehringer Ingelheim Venture Fund commented: "We are excited to support Asgard Therapeutics and its founder team as co-lead of this seed investment. The seminal work conducted at Lund University by Cristiana Pires, Filipe Pereira, and Fábio Rosa enables the direct conversion of non-related somatic cells into antigen presenting cells with a completely novel cellular identity. We believe this approach holds the potential to significantly impact the way cancer immunotherapy will evolve in the future and to bring new treatment options with true breakthrough potential to cancer patients in need."

Bita Sehat from Industrifonden said: "Asgard’s novel gene therapy approach to reprogram cancer cells into antigen-presenting cells holds great promise to open up new avenues within the immune-oncology space. We are pleased to co-lead this round and look forward to partnering with this strong group of investors and distinguished scientists as the co-founding team to advance what we believe will be a broadly applicable new cancer treatment platform."

Asgard Therapeutics has received support from LU Innovation and several translational grants, including from the Novo Nordisk Foundation, the European Commission’s Horizon 2020 and the Swedish Innovation Agency Vinnova. Asgard Therapeutics is also supported by the BioInnovation Institute in Copenhagen, and a member of the Nordic Mentor Network for Entrepreneurship (NOME) mentoring program. Being a SmiLe incubator company, Asgard is now setting up a new lab at SmiLe, Medicon Village, and will be expanding its research and drug development teams.

As part of the transaction, Søren Møller (Novo Holdings), Philipp Müller (BIVF) and Jonas Jendi (Industrifonden) join current Board Members Filipe Pereira and Lars Hedbys. João Ribas (Novo Holdings) and Fábio Rosa (Asgard Therapeutics) will also join as Board Observers.

On November 9, 2021 Prenetics Group Limited ("Prenetics" or the "Company"), a global leader in genomic and diagnostic testing, reported its financial results for the six months ended June 30, 2021 (Press release, Prenetics, NOV 9, 2021, View Source [SID1234594907]). Prenetics delivered significant revenue growth, driven by continued demand across the world for its genomic and diagnostic testing services, including increased demand for COVID-19 testing as travel gradually resumes globally.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The Company has publicly filed a registration statement on Form F-4 ("the Registration Statement") with the U.S. Securities and Exchange Commission ("SEC"), which contains a preliminary proxy statement/prospectus in connection with its previously announced proposed business combination with Artisan, a special purpose acquisition company founded by Adrian Cheng. The planned business combination continues to progress and is expected to close in the first quarter of 2022.

"We are pleased with our progress toward becoming a publicly-traded company, which we expect to occur in the first quarter of 2022. Prenetics again passed many milestones in the first half of 2021, growing revenue by 1,039% year on year, indicating a strong increase in demand for our testing services and the robustness of our technology. Going forward, we will continue to execute our growth strategy to put us amongst the fastest growing healthcare companies worldwide." said Danny Yeung, Group CEO & Co-founder of Prenetics.

He continued, "But I believe we are just getting started. We are at an inflection point within the healthcare ecosystem on how healthcare is to be delivered. Prenetics has a strong product pipeline and, as part of our global M&A strategy, we have already identified international targets in the area of rapid diagnostics and in digital health which would be highly complementary to our mission of decentralizing healthcare and bringing healthcare closer to millions of people globally."

Prenetics has a strong existing business and a robust product pipeline which include:

Circle HealthPod – Health Monitoring System providing rapid, lab-quality molecular testing for COVID-19 — anytime, anywhere. Circle HealthPod has received CE-IVD mark for point-of-care use. A usability study was completed in the U.S. and a clinical validation is in progress with aim to receive EUA from U.S. FDA by the first half of 2022. The Company has already begun developing assays to expand Circle HealthPod’s testing capacity to cover a range of tests traditionally conducted in clinical laboratories such as tests for influenza and STDs.

Circle ColoClear – Non-invasive stool-based FIT-DNA test for colorectal cancer screening. To be launched in the first half of 2022.

Circle SnapShot – At-home blood test with a user-friendly blood sample collection and result delivery system. To be launched in 2022.
Financial Highlights for the Six Months ended June 30, 2021

(1) For a reconciliation to the most directly comparable IFRS measure see the section titled "Unaudited Financial Information and Non-IFRS Financial Measures."

Revenue reached an all-time-high of US$136.5 million, an increase of 1,039% from US$12.0 million in the same period in 2020. This uplift was driven by increased demand for laboratory testing, including travel related COVID-19 testing.

For the six months ended June 30, 2021, Prenetics’ clients for its COVID-19 testing services include the Hong Kong government, Hong Kong International Airport, Multiple UK Airports, English Premier League and several global corporates including Virgin Atlantic, Carnival Cruise Line, and Sky TV.

Adjusted gross profit was US$57.0 million, an increase of 1,257%, from US$4.2 million in the same period in 2020, delivering a gross margin of 41.8%.

Adjusted EBITDA was US$31.5 million, increased by US$34.6 million year-over-year, due to increased operating efficiencies and scalability of the business.

As of June 30, 2021, the Company had cash and trade receivables of US$97.9 million, consisting of US$37.6 million of cash and US$60.3 million of trade receivables.
Recent Business Highlights

Prenetics announced on September 16, 2021 that it had entered into a definitive merger agreement with Artisan, a special purpose acquisition company privately founded by Adrian Cheng. The completion of the transaction is estimated to be by the first quarter of 2022. Upon completion of the transaction, the combined company ("PubCo")’s securities are expected to be traded on the Nasdaq under the ticker symbol "PRE".

Prenetics has now processed more than 6 million laboratory tests. On October 19, 2021, the Company announced that it was appointed as the official RT-PCR COVID-19 testing partner for the Standard Chartered Hong Kong Marathon 2021 that took place on October 24, 2021.

The Company continues to expand the utility and opportunity of next generation sequencing technologies in both consumer and clinical settings. In November 2021, the Company announced the addition of PacBio’s SMRT HiFi sequencing technology to its genetic screening services. PacBio’s technology will be a key component of Prenetics’ Circle Medical offering, a genetic test geared towards addressing the diagnostic needs of physicians and improving the accuracy of detecting mutations.

The Company has signed a strategic partnership agreement with EC Healthcare (stock code: 2138 Hong Kong), Hong Kong’s largest non-hospital medical group, to integrate all of Prenetics testing services as a service offering to EC Healthcare’s patients.

Prenetics has also made additions to its senior management team to support the company’s rapid growth. Yvonne Wong joined as the Chief Corporate Development Officer and is responsible for leading the company’s corporate development, ESG and CSR efforts. She has over 28 years of experience working in top-tier financial institutions and advising family offices and NGOs. CY Chan joined as the Chief People Officer and is responsible for leading the company’s people operations and culture strategy. He was formerly the CPO of HKBN Ltd. leading its HR and CSR functions.

Outlook

Based on its robust performance in the first half of 2021, Prenetics expects its revenue for 2021 to be ahead of its previous forecast of $205 million stated in the Investor Presentation of Artisan and Prenetics dated September 15, 2021. Whilst the Company is encouraged by the growth trajectory it has achieved, it maintains its projected annual revenues of more than US$600 million in 2025.

On November 9, 2021Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, reported the upcoming presentation of preclinical data highlighting P-BCMA-ALLO1 for the treatment of relapsed/refractory multiple myeloma and P-MUC1C-ALLO1 for the treatment of multiple solid tumor indications at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 2021 Annual Meeting (SITC) (Free SITC Whitepaper), being held in Washington, D.C., and virtually November 10-14, 2021 (Press release, Poseida Therapeutics, NOV 9, 2021, View Source [SID1234594923]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We are pleased to share preclinical data for P-BCMA-ALLO1 and P-MUC1C-ALLO1, our first fully allogeneic candidates," said Devon Shedlock, Ph.D., Chief Scientific Officer, Cell Therapies at Poseida Therapeutics. "The results being shared at SITC (Free SITC Whitepaper) not only demonstrate potent antitumor efficacy in preclinical models for our allogeneic product candidates, but also further validate the capabilities of our piggyBac and Cas-CLOVER technologies. Using our proprietary manufacturing process which includes our booster molecule, we have the potential to produce hundreds of patient doses from a single manufacturing run while also preserving high levels of stem cell memory T cells (TSCM), which are correlated with antitumor efficacy in the clinic. We have recently received FDA clearance on our P-BCMA-ALLO1 IND and are in the process of initiating a Phase 1 trial. We look forward to advancing our P-MUC1C-ALLO1 CAR-T candidate with an IND filing expected later this year."

Poseida is presenting two posters, which will be on display on the SITC (Free SITC Whitepaper) 2021 virtual meeting platform from 7 a.m. EST on Friday, Nov. 12, 2021 until the virtual meeting platform is closed on Jan. 9, 2022.

Presentation Highlights:

In the poster titled "Memory Phenotype in Allogeneic Anti-BCMA CAR-T Cell Therapy (P-BCMA-ALLO1) Correlates with In Vivo Tumor Control" (Abstract Number 147), Hubert Tseng, Ph.D., Poseida Therapeutics, will highlight:

Using the Company’s piggyBac DNA Delivery System in combination with its Cas-CLOVER gene editing system and a proprietary "booster molecule," Poseida generated doses of P-BCMA-ALLO1 from healthy donor T cells and consistently maintain high frequency of stem cell memory T cells.
Cas-CLOVER was used to eliminate surface expression of both the TCR and MHC class I to make fully allogeneic CAR-T cells. In addition to the CAR molecule, piggyBac enables delivery of a selectable marker allowing the generation of a final cell product that is >95% CAR-positive.
P-BCMA-ALLO1 is comprised of a high frequency of TSCM. It has potent in vivo antitumor activity, which is comparable to non-edited autologous anti-BCMA CAR-T cell therapy. Expression of memory markers at both the mRNA and protein levels across individual lots significantly correlates with in vivo tumor control.
P-BCMA-ALLO1 is a highly potent and safe allogeneic anti-BCMA CAR with a manufacturing process that consistently maintains a TSCM phenotype, which correlates with antitumor efficacy. P-BCMA-ALLO1 has received FDA IND clearance and is advancing rapidly toward the clinic.
In the poster titled "P-MUC1C-ALLO1: A Fully Allogeneic Stem Cell Memory T Cell CAR-T Therapy with Broad Potential in Solid Tumor" (Abstract Number 123), Yan Zhang, Ph.D., Poseida Therapeutics, will highlight:

P-MUC1C-ALLO1 is manufactured using Poseida’s piggyBac DNA delivery system and Cas-CLOVER gene editing system to knockout both the TCR and MHC class I proteins. Poseida can generate significant doses of P-MUC1C-ALLO1 including a high-percentage of desirable TSCM cells.
P-MUC1C-ALLO1 displayed specificity for tumor vs normal cells: MUC1C CAR-T cells had potent cytotoxicity against tumor cells, and minimal killing of normal MUC1-C-positive human primary cells.
In a triple negative breast cancer xenograft model, P-MUC1C-ALLO1 eliminated established tumor cells, demonstrating robust T cell expansion in peripheral blood and maintained a favorable TSCM percentage over time.
P-MUC1C-ALLO1 has also shown robust efficacy in a peritoneal ovarian cancer xenograft model, eliminating established tumor cells to undetectable levels with minimal toxicity.
About P-BCMA-ALLO1
P-BCMA-ALLO1 is Poseida’s first fully allogeneic product candidate targeting B-cell maturation antigen (BCMA) for the treatment of relapsed/refractory multiple myeloma. In in vitro and in vivo preclinical studies, P-BCMA-ALLO1 showed effective targeted cancer cell killing and cytokine secretion, with similar or superior performance in anti-tumor efficacy compared to an autologous CAR-T therapy, P-BCMA-101. Inclusion of a proprietary booster molecule in the allogeneic manufacturing process further improves expansion of gene-edited cells and may potentially enable production of hundreds of patient doses from a single manufacturing run, thereby potentially reducing the manufacturing cost per dose into the same range as that of a monoclonal antibody. In August 2021, Poseida announced that its Investigational New Drug (IND) application for P-BCMA-ALLO1 received clearance from the U.S. Food and Drug Administration (FDA).

About P-MUC1C-ALLO1
P-MUC1C-ALLO1 is an allogeneic CAR-T product candidate in preclinical development with the potential to treat a wide range of solid tumors derived from epithelial cells, including breast and ovarian cancers, as well as other cancers expressing a cancer-specific form of the Mucin 1 protein, or MUC1C. We have designed P-MUC1C-ALLO1 to be fully allogeneic, with genetic edits to eliminate or reduce both host-vs-graft and graft-vs-host alloreactivity. We have demonstrated the elimination of tumor cells to undetectable levels in preclinical models of breast cancer and ovarian cancer.

On November 9, 2021 Wugen, Inc., a clinical-stage biotechnology company developing a pipeline of off-the-shelf memory natural killer (NK) cell therapies to treat a broad range of hematological and solid tumor malignancies, reported it will present new data highlighting the preclinical development of Wugen’s lead product WU-NK-101 at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 36th Annual Meeting (Press release, Wugen, NOV 9, 2021, View Source [SID1234594939]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The data highlight Wugen’s proprietary large-scale feeder-cell free manufacturing process and demonstrate WU-NK-101’s robust memory phenotype and enhanced anti-tumor activity. Further, the data demonstrate that in combination with monoclonal antibodies, WU-NK-101 exhibits enhanced efficacy against solid tumor cell lines. In summary, the data provide support for development of WU-NK-101 as an off-the-shelf cell therapy for the treatment of acute myelogenous leukemia (AML) and solid tumors.

The details of Wugen’s presentation at SITC (Free SITC Whitepaper) are as follows:

Title: Development of WU-NK-101, a feeder cell-free expanded allogeneic memory NK cell product with potent anti-tumor activity
Presenting Author: Mary E. Mathyer, Ph.D.
Abstract Number: 188
Abstracts will be available Tuesday, November 9, 2021, at 8:00 a.m. ET
Additional meeting information can be found on the SITC (Free SITC Whitepaper) website at:
View Source

On November 9, 2021 NANOBIOTIX (Euronext: NANO – NASDAQ: NBTX – the "Company"), a late-stage clinical biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer, reported new preclinical immunotherapy data for novel, potentially solid tumor- and therapeutic combination-agnostic radioenhancer NBTXR3 that will be presented at the 2021 Annual Meeting of the Society for the Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) (Press release, Nanobiotix, NOV 9, 2021, View Source [SID1234594955]). The Company believes that these data are consistent with recently presented clinical immunotherapy data and support advancement of development with anti-PD-1 and emerging immune checkpoint inhibitors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Our view is that the potential immune priming effect we have observed with NBTXR3 could make our product candidate an important combination therapy with immune checkpoint inhibitors to improve treatment outcomes for patients," said Laurent Levy, co-founder and chief executive officer of Nanobiotix. "The new preclinical data at SITC (Free SITC Whitepaper), along with data we have evaluated in the clinical setting, present a promising path forward in immunotherapy."

Preclinical data to be presented at the meeting by Nanobiotix (Abstract #740) show that radiotherapy-activated NBTXR3 increases CD8+ T cell infiltration and modulates the T cell receptor ("TCR") repertoire, as well as marked modulation of immunopeptidome in treated tumor cells in a mouse model. Taken together, these variations could indicate that radiotherapy-activated NBTXR3 triggers more robust immune priming than radiotherapy alone and merits further evaluation of CD8+ response and abscopal effect.

The Company’s perspective is that these data further support the mechanistic rationale of combining NBTXR3 with immune checkpoint inhibitors. The preclinical data follows preliminary clinical data presented earlier in the fourth quarter of 2021 from the phase I trial ("Study 1100") evaluating NBTXR3 in combination with the anti-PD-1 checkpoint inhibitors nivolumab (Opdivo) or pembrolizumab (Keytruda) in patients with locoregional recurrent ("LRR") or recurrent and metastatic ("R/M") head and neck squamous cell carcinoma ("HNSCC") or with lung or liver metastases from any primary cancer that is eligible for anti-PD-1 therapy. This preliminary data for Study 1100 showed an overall AE profile consistent with radiotherapy or anti-PD-1 monotherapies. A 56% target lesion objective response rate (80% in anti-PD-1 naïve patients; 45% in prior non-responders) was observed in evaluable patients (n=16). A 50% overall objective response rate (% response in target and non-target lesions) was observed (80% in anti-PD-1 naïve patients; 36% for prior non-responders) in evaluable patients. The potential immune priming effect of radiotherapy-activated NBTXR3 was observed in non-responders as well as anti-PD-1 naïve patients, suggesting that NBTXR3 may reverse or circumvent resistance to prior anti-PD-1 treatment.

Evaluation of novel combination approaches to immunotherapy continues to be a priority for Nanobiotix, as investigators seek to expand the impact of I/O agents for the 80-85% of patients that receive limited benefits, or no benefit at all, by improving response rates and overcoming resistance to anti-PD-1. TIGIT and LAG3, members of the same receptor class as CTLA-4 and PD-1, could be the next generation of immunotherapy targets and are being investigated alone and in combination with existing anti-PD-1 agents aiming to improve patient outcomes in clinical trials.

The preclinical data to be presented at SITC (Free SITC Whitepaper) by The University of Texas MD Anderson Cancer Center (Abstract #575) show that radiotherapy-activated NBTXR3 plus anti-PD-1, anti-TIGIT, and anti-LAG3 ("Combo therapy") significantly promotes the proliferation activity of CD8+ T cells, improves local and distant tumor control, and increases survival rate in mice. Only the group of mice treated with the Combo therapy had survivors and those cured mice were immune to re-injection of tumor cells, maintained a significantly higher percentage of memory CD4+ and CD8+ memory T cells, and had stronger anti-tumor immune activities than the control, suggesting the induction of long-term anti-tumor memory by the Combo therapy.

"We have long believed that radiotherapy has a critical role to play in immunotherapy and that innovation in the practice is key to achieving this ambition," said James Welsh, MD, Associate Professor of Radiation Oncology at MD Anderson. "Our preclinical research on NBTXR3 has consistently supported the potential of this new agent in combination with radiotherapy and immune checkpoint inhibitors in order to enhance immunogenic cell death. We look forward to continuing our evaluation, both in the lab and in the clinic, with the ultimate goal of improving treatment outcomes for patients."

About NBTXR3
NBTXR3 is a novel, potentially first-in-class oncology product composed of functionalized hafnium oxide nanoparticles that is administered via one-time intratumoral injection and activated by radiotherapy. The product candidate’s physical mechanism of action (MoA) is designed to induce significant tumor cell death in the injected tumor when activated by radiotherapy, subsequently triggering adaptive immune response and long-term anti-cancer memory. Given the physical MoA, Nanobiotix believes that NBTXR3 could be scalable across any solid tumor that can be treated with radiotherapy and across any therapeutic combination, particularly immune checkpoint inhibitors.

NBTXR3 is being evaluated in locally advanced head and neck squamous cell carcinoma (HNSCC) as the primary development pathway. The company-sponsored phase I dose escalation and dose expansion study has produced favorable safety data and early signs of efficacy; and a phase III global registrational study is planned to launch in 2021. In February 2020, the United States Food and Drug Administration granted regulatory Fast Track designation for the investigation of NBTXR3 activated by radiation therapy, with or without cetuximab, for the treatment of patients with locally advanced HNSCC who are not eligible for platinum-based chemotherapy—the same population being evaluated in the planned phase III study.

Nanobiotix has also prioritized an Immuno-Oncology development program—beginning with a Company sponsored phase I clinical study evaluating NBTXR3 activated by radiotherapy in combination with anti-PD-1 checkpoint inhibitors for patients with locoregional recurrent or recurrent/metastatic HNSCC and lung or liver metastases from any primary cancer eligible for anti-PD-1 therapy.

Given the Company’s focus areas, and balanced against the scalable potential of NBTXR3 , Nanobiotix has engaged in a strategic collaboration strategy with world class partners to expand development of the product candidate in parallel with its priority development pathways. Pursuant to this strategy, in 2019 Nanobiotix entered into a broad, comprehensive clinical research collaboration with The University of Texas MD Anderson Cancer Center to sponsor several phase I and phase II studies to evaluate NBTXR3 across tumor types and therapeutic combinations.