On November 3, 2021 Cellectis S.A. (NASDAQ: CLLS – EURONEXT GROWTH: ALCLS) (the "Company"), a gene-editing company with clinical-stage immuno-oncology programs using allogeneic chimeric antigen receptor (CAR)-T cells and gene therapy programs for genetic diseases, reported the release of two abstracts, which were accepted for presentation at the 63rd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting taking place from December 11-14, 2021 (Press release, Cellectis, NOV 3, 2021, View Source [SID1234594350]). The Company will present updated preliminary clinical data from its BALLI-01 clinical trial in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL), and preclinical data for TALGlobin01 for patients with HbSS Sickle Cell Disease (SCD).

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"2021 has been a busy and productive year for Cellectis, with our proprietary clinical and preclinical programs making noteworthy progress. Cellectis is advancing one of the most robust allogeneic CAR-T pipelines and we are excited to share additional preliminary data from our BALLI-01 clinical trial, which is evaluating UCART22, in patients with relapsed and refractory B-cell acute lymphoblastic leukemia for whom there continues to be an urgent need for safe and effective treatments. We are also proud to disclose initial pre-clinical data from our .HEAL platform’s product candidate, TALGlobin01, which demonstrates that TALEN could be specific and efficient at correcting the mutated beta-globin gene, the underlying cause of sickle cell disease," said Carrie Brownstein, MD, Chief Medical Officer at Cellectis.

Cellectis Poster Presentations

BALLI-01 investigating UCART22 product candidate in R/R B-ALL

The abstract includes updated preliminary data from the Phase I, open-label, dose-escalation BALLI-01 study in patients with R/R B-ALL from the first cohort of patients who received UCART22 after FCA (fludarabine, cyclophosphamide and alemtuzumab) lymphodepletion. The data show that the addition of alemtuzumab to fludarabine and cyclophosphamide was well tolerated, deepened host T-cell depletion and promoted CAR-T cell expansion.

UCART22 is a novel and genetically modified allogeneic T-cell product manufactured from healthy donor cells. T-cells are transduced using a lentiviral vector to express the anti-CD22 chimeric antigen receptor (CAR) and are modified to disrupt the T-cell receptor alpha constant (TRAC) and CD52 genes to minimize risk of graft-vs-host disease (GvHD) and to allow use of anti-CD52–directed drugs for lymphodepletion.

These data are encouraging and support the continued enrollment into the study. Additional data will be presented at the congress.

Poster Abstract Session:
Title: Preliminary Results from the Flu/Cy/Alemtuzumab Arm of the Phase I BALLI-01 Trial of UCART22, an Anti-CD22 Allogeneic CAR-T Cell Product, in Adult Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Abstract: #1746
Presenter: Jain Nitin, MD, The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
Session Name: 704, cellular immunotherapies, Clinical Poster I
Date & Time & Location: December 11, 2021 5:30-7:30PM ET, Georgia World Congress Center, Hall B5

TALGlobin01; an autologous ex vivo TALEN-edited CD34+ HSC therapy for the treatment of Sickle Cell Disease

Sickle cell disease (SCD) is a common inherited disease that stems from a single mutation in the HBB gene.

TALGlobin01 is an autologous cell-based gene therapy product designed to repair the mutated b-globin gene (HBB), and subsequently restore production of Hemoglobin A in HBSS sickle cell disease.

The data that will be presented are the first demonstration that TALEN-based engineering could be used to correct the mutation in the beta-globin gene of homozygous sickle cell anemia patient-derived hematopoietic stem and progenitor cells. The data showed high level of hemoglobin A expression, reversion of sickling phenotype, the capacity of TALGlobin01 edited cells to engraft in vivo, and a low level of off-target cleavage. Collectively, the data demonstrate high efficiency and safety of TALEN treatment in HSPCs and positioned it as the best-in-class gene editing technology for gene therapy product development.

Poster Abstract Session:

Title: Pre-clinical development of a highly efficient TALEN-based correction of β-globin gene in patient-derived hematopoietic stem and progenitor cells (HSPCs) to treat sickle cell disease
Abstract: #1856
Presenter: Julien Valton, PhD, Vice President Gene Therapy, Cellectis
Session Name: 801, Gene therapies Poster I
Session Date & Time & Location: Dec 11, 2021, 5:30-7:30PM ET, Georgia World Congress Center, Hall B5

ASH abstracts are now available on www.hematology.org

On November 3, 2021 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported its operational and financial results for the third quarter ended September 30, 2021 (Press release, Autolus, NOV 3, 2021, View Source [SID1234594461]).

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"We continue to make good progress on the clinical evaluation of obe-cel in the Phase 2 portion of the FELIX study and remain on track to deliver primary endpoint data in the middle of 2022. We are also pleased to update that the response rate and safety data from patients in the multi-center Phase 1b cohort are consistent with the data reported from the academic ALLCAR19 study of obe-cel in relapsed/refractory adult B-acute lymphoblastic leukemia (ALL)," said Dr. Christian Itin, chief executive officer of Autolus. "In addition, we expect a busy end of the year with clinical data at the upcoming 63rd Annual Meeting of the American Society of Hematology (ASH) (Free ASH Whitepaper), including an oral presentation, where we will provide early clinical data from the Phase 1b trial, as well as a poster presentation covering clinical data from the ALLCAR19 extension trial and a poster with initial clinical data for AUTO1/22."

Key Pipeline Updates:

Obecabtagene autoleucel (obe-cel) in relapsed / refractory (r/r) adult ALL.
FELIX Study – Autolus continues to enroll patients in the Phase 2 portion of the FELIX study. The multi-center study is progressing well, with consistent one-month complete response rate and safety data observed from the initial 16 patients in the Phase 1b cohort as compared to data reported from the academic ALLCAR19 study of obe-cel in r/r adult ALL. Autolus expects to present early clinical data from the Phase 1b portion of the FELIX trial at the 63rd ASH (Free ASH Whitepaper) Meeting in December 2021. The Company reiterates its expectation of pivotal data in 2022.
ALLCAR19 Study – Data were published in the Journal of Clinical Oncology (JCO) in September 2021 from the ALLCAR19 trial in r/r adult ALL patients. Obe-cel demonstrated a manageable adverse events profile, with no patients experiencing high grade (≥ grade 3) cytokine release syndrome (CRS), despite the majority having a high disease burden prior to lymphodepletion1. CAR T cell concentration reached very high levels at peak (mean peak CAR T concentration (Cmax) by quantitative polymerase chain reaction (qPCR) was 127,152 copies/µg genomic DNA1) and persistence in peripheral blood was evident in 15/20 (75%) patients at a median of 166.5 days, with 4/20 (20%) patients having follow-up duration over 2 years, and 3/4 of these patients with ongoing CAR persistence at the data cut-off date of February 26, 20211. B-cell aplasia was ongoing in 15/20 patients at the last observation date of February 26, 20211. Of the 20 patients, 85% patients achieved minimal residual disease (MRD) negative complete response (CR) at month 11. Duration of response remains highly encouraging. With a data cut-off date of May 17, 2021, and as presented at the European Hematology Association (EHA) (Free EHA Whitepaper) Virtual Congress in June 2021, event free survival (EFS) at 12 months and 24 months was 50.2%, with median EFS not reached across all patients treated2.
1Roddie et al. "Durable responses and low toxicity after fast off-rate CD19 CAR-T therapy in adults with relapsed/ refractory B-ALL." DOI: 10.1200/JCO.21.00917 Journal of Clinical Oncology – published online before print August 31, 2021

2Roddie et al. "Early Safety and Efficacy Findings of AUTO1 (CAT19), a Fast-Off Rate CD19 CAR, in Relapsed/Refractory Indolent B Cell Lymphomas." EHA (Free EHA Whitepaper) annual meeting, June 11 2021, abstract EP788. EHA (Free EHA Whitepaper) Investor slide presentation

Obe-cel in r/r B-NHL – ALLCAR19 extension
The latest data of obe-cel were presented by Autolus at EHA (Free EHA Whitepaper) in June 2021 in r/r B-NHL (Follicular Lymphoma and Mantle Cell Lymphoma) patients. The trial is progressing well and Autolus plans to present updated data from the ALLCAR extension trial at the ASH (Free ASH Whitepaper) Meeting in December 2021.
AUTO4 in Peripheral T Cell Lymphoma
The AUTO4 Phase 1 clinical trial is progressing through dose escalation and Autolus expects to provide its next data update from the trial in the first half of 2022.
AUTO8 in Multiple Myeloma
The Company is on track to start a Phase 1 trial in the fourth quarter of 2021.
Operational Highlights:

Updates to Autolus’ Executive team
In July 2021, Autolus announced the appointment of Edgar Braendle M.D., Ph.D., as Chief Development Officer. Dr Braendle is an experienced oncologist who joined Autolus from Sumitomo Dainippon Pharma Oncology, where he held the position of Chief Medical Officer and Global Head of Development and was responsible for leading the global oncology development programs of Sumitomo Dainippon. In addition, in June 2021, Wolfram Brugger M.D., Ph.D. joined Autolus as its Vice President, Head of Clinical Development. Dr. Brugger joined Autolus from MorphoSys, where he was Head of Global Clinical Programs and oversaw the development of Monjuvi (tafasitamab).

In October 2021, Alexander Swan was promoted to Senior Vice President, Human Resources. Mr. Swan joined Autolus prior to its Nasdaq listing in 2018 as Vice President, Human Resources. Prior to that, he was EMEA Head of Human Resources for Kite where he was responsible for all aspects of human resources.

Also in October 2021, Dr. Chris Williams was promoted to Senior Vice President, Corporate Development. Dr. Williams was part of the team that founded Autolus in 2014, and he initially served on the Company’s board of directors as a Non-Executive Director from September 2014 to July 2016. In 2016, Dr. Williams transitioned into the Company to establish Autolus’ business development function. Previously he worked at UCL Business, Orchard Therapeutics, Eli Lilly, and GSK.

Matthias Alder, Senior Vice President, Chief Business Officer and Company Secretary, left Autolus at the end of September 2021. The Company would like to thank Mr. Alder for his contributions and wishes him well in the future.
In September 2021, Autolus announced the appointment of John H. Johnson as non-executive chairman of its Board of Directors. Mr. Johnson brings to Autolus more than 30 years of experience in the life science industry. He most recently was chief executive officer and a director of Strongbridge Biopharma plc, a Nasdaq-listed commercial stage biopharmaceutical company. He previously served as the executive chairman of Strongbridge Biopharma from November 2019 to July 2020, and as chairman from March 2015 to November 2019. He is a recognized leader in the biopharmaceutical industry and has held executive, operations and commercial leadership roles at Eli Lilly & Company, ImClone, Johnson & Johnson, and Pfizer. He also currently serves as a member of the Board of Directors of Xeris Biopharma Holdings, Inc., Verastem, Inc. and Axogen, Inc. Mr. Johnson previously served on the Board of Directors of the Pharmaceutical Research and Manufacturers of America and the Health Section Governing Board of the Biotechnology Industry Organization (now known as the Biotechnology Innovation Organization).

In September 2021, Autolus gave an update on its manufacturing strategy, announcing that planning approval had been granted to build the Company’s new manufacturing facility in Stevenage, UK. The 70,000 square foot facility is being built by Merit Holdings Limited as general contractor for the Reef Group, who will lease the facility to Autolus. Global commercial launch capacity for obe-cel will initially be provided by the existing clinical trial manufacturing facility at The Cell and Gene Therapy Catapult facility, and will then move to the new Autolus facility, which will allow for good manufacturing practice capacity for approximately 2,000 batches a year initially, with scope to expand.

As previously announced, in July 2021, Autolus announced its entry into an agreement with Moderna, Inc., granting Moderna an exclusive license to develop and commercialize mRNA-based therapeutics incorporating Autolus’ proprietary binders for up to four immuno-oncology targets.
Key Anticipated Clinical Milestones:

Updates on the FELIX trial, where Autolus is evaluating obe-cel in r/r adult ALL patients. The trial is currently enrolling patients into the Phase 2 portion. Initial data on the Phase 1b portion of the trial planned to be presented at the ASH (Free ASH Whitepaper) Meeting in December 2021. Autolus expects data from the Phase 2 trial to be available in 2022

Updates from the ALLCAR19 extension trial in patients with r/r B-NHL and longer-term follow-up of the fully enrolled r/r adult ALL cohort expected at ASH (Free ASH Whitepaper) Annual Meeting in December 2021

Updates on the obe-cel Phase 1 trial, CAROUSEL, in Primary CNS Lymphoma in Q1 2022

Non-clinical data and initial data from the AUTO1/22 CARPALL extension trial in pediatric ALL expected at ASH (Free ASH Whitepaper) in December 2021

Updates on the AUTO4 Phase 1 trial in TRBC1+ Peripheral TCL expected in H1 2022

Phase 1 trials are expected to be initiated in Q4 2021 with AUTO8 in Multiple Myeloma

Phase 1 trials are expected to be initiated in H1 2022 with AUTO6NG in solid tumors and AUTO5 in TRBC2+ Peripheral TCL
Financial Results for the Quarter Ended September 30, 2021

Cash at September 30, 2021, totaled $173.1 million, as compared to $216.4 million at June 30, 2021.

Net total operating expenses for the three months ended September 30, 2021, were $40.4 million, net of grant income of $0.2 million, as compared to net operating expenses of $42.7 million, net of grant income of $0.4 million and license revenue of $0.2 million, for the same period in 2020.

Research and development expenses decreased to $32.3 million for the three months ended September 30, 2021 from $33.5 million for the three months ended September 30, 2020. Cash costs, which exclude depreciation and amortization as well as share-based compensation, decreased to $29.4 million from $30.0 million. The decrease in research and development cash costs of $0.6 million consisted primarily of (i) $1.4 million decrease in clinical costs and manufacturing costs (ii) $0.2 million decrease of consultancy fees related to our clinical pipeline, (iii) $0.3 million decrease in facilities costs related to the termination of our US manufacturing facility and shift in manufacturing strategy, (iv) $0.4 million in research and development costs related to cell logistics and (v) $0.1 million decrease related to information technology infrastructure and support for information systems related to the conduct of clinical trials and manufacturing operations . This was offset by (i) an increase of $1.0 million related to purchased consumables for the manufacture of obe-cel in our Phase 2 FELIX clinical trial and (ii) an increase in compensation and employment related costs of $0.8 million net, due to a combination of severance payments which are offset by a reduction in employment costs for a decrease in headcount.

Non-cash costs decreased to $2.9 million for the three months ended September 30, 2021 from $3.5 million for the three months ended September 30, 2020. The decrease is primarily related to share-based compensation expense included in research and development expenses, which decreased by $1.6 million as a result of the lower fair value of stock options granted during the period, combined with forfeitures of incentive share options and unvested RSU awards. This was offset by an increase in depreciation expense of $1.0 million.

General and administrative expenses decreased to $8.3 million for the three months ended September 30, 2021 from $9.8 million for the three months ended September 30, 2020. Cash costs, which exclude depreciation expense as well as share-based expense compensation decreased to $7.2 million from $7.7 million. The decrease in general and administrative cash costs of $0.5 million related to decreases of (i) $0.2 million associated with compensation expense due to a reduction in headcount, (ii) $0.8 million of expenses related to preparations for becoming a commercial stage company, and (iii) $0.4 million in facilities costs related to the termination lease and exit of our lease agreements. These decreases were offset by an increase of $0.8 million which was primarily related to professional services fees and directors and officers liability insurance premiums and $0.1 million in costs related to IT infrastructure and support for information systems.

Non-cash costs decreased to $1.1 million for the three months ended September 30, 2021 from $2.1 million for the three months ended September 30, 2020. The decrease is mainly attributed to share-based compensation expense as a result of the lower fair value of stock options recognized during the period, combined with forfeitures of incentive share options and unvested RSU awards related to employees affected by our reduction in workforce.

Other income / (expense) increased by $3.5 million for the three months ended September 30, 2021, from other expense of $2.5 million for the three months ended September 30, 2020 to other income of $1.0 million. The increase was primarily due to the strengthening of the U.S. dollar exchange rate relative to the pound sterling during the three months ended September 30, 2021 as compared to the three months ended September 30, 2020.

Income tax benefit decreased to $5.4 million for the three months ended September 30, 2021 from $7.9 million for the three months ended September 30, 2020 due to a decrease in the research and development expenditures which were qualifying for the quarter. As research and development credits fell at a faster rate than our net loss before income tax, this led to a lower effective tax rate. Research and development credits are obtained at a maximum rate of 33.35% of our qualifying research and development expenses, and the decrease in the net credit was primarily attributable to a decrease in our eligible research and development expenses.

Net loss attributable to ordinary shareholders was $34.0 million for the three months ended September 30, 2021, compared to $37.3 million for the same period in 2020. The basic and diluted net loss per ordinary share for the three months ended September 30, 2021, totaled $(0.47) compared to a basic and diluted net loss per ordinary share of $(0.72) for the three months ended September 30, 2020.

Autolus estimates that its current cash on hand will provide the Company with a cash runway into H1 2023.

Conference Call

Management will host a conference call and webcast today at 8:30 am ET/12:30 pm GMT to discuss the Company’s financial results and provide a general business update. To listen to the webcast and view the accompanying slide presentation, please go to the events section of Autolus’ website.

The call may also be accessed by dialing (866) 679-5407 for U.S. and Canada callers or (409) 217-8320 for international callers. Please reference conference ID 6984737. After the conference call, a replay will be available for one week. To access the replay, please dial (855) 859-2056 for U.S. and Canada callers or (404) 537-3406 for international callers. Please reference conference ID 6984737.

On November 3, 2021 The Parker Institute for Cancer Immunotherapy (PICI) and the Cancer Research Institute (CRI) reported the dosing of the first patients in the REVOLUTION trial, a phase I, open label platform study of novel immunotherapy combinations for first-line treatment of metastatic pancreatic cancer (Press release, Cancer Research Institute, NOV 3, 2021, View Source [SID1234594209]).

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"PICI is built on the promise of bringing together the brightest minds to come up with innovative solutions to cancer’s toughest problems, and this trial is a direct result," said Ute Dugan, MD, PhD, PICI’s Chief Medical Officer. "The innovative design also represents a new model of collaborative, end-to-end drug development that allows us to more rapidly advance promising therapeutic combinations from bench to bedside to market, and then to patients."

REVOLUTION uses a platform trial design that allows for more rapid testing of several therapies with more adaptability than a standard clinical trial. In a traditional clinical trial, all elements of the study must be approved prior to beginning. When the study meets its endpoint, researchers must decide what study to do next based on the findings.

In contrast, a platform design allows researchers to interpret the data during the trial and to make changes, such as testing additional treatments, expanding the number of people receiving a therapy that shows promise, or discontinuing a therapy that does not look promising. This allows investigators to follow the science with flexibility and efficiency, avoiding some of the administrative and logistical hurdles involved in starting up individual trials in a safe way and decreasing the likelihood that patients will receive ineffective treatments.

"Platform studies offer a science-informed flexibility that is better able to keep pace with the accelerating advances in clinical cancer immunology, especially those that involve promising drug combinations like those brought together through the Cancer Research Institute’s collaborations with PICI and our academic, industry, and other nonprofit partners," said Jill O’Donnell-Tormey, PhD, CEO and Director of Scientific Affairs at CRI.

REVOLUTION currently consists of two groups of patients. Cohort A will test a combination of standard-of-care chemotherapy, the CTLA-4 inhibitor ipilimumab and the PD-1 inhibitor nivolumab. In addition to providing valuable information on the efficacy of the combination itself, this cohort builds on the findings from PICI’s and CRI’s PRINCE trial, which suggested that the combination of chemotherapy and anti-PD-1 treatment may improve survival compared with chemotherapy alone.

Cohort B will investigate the combination of chemotherapy, ipilimumab and hydroxychloroquine (HCQ). HCQ is a drug that can stop a process called autophagy, which cells use to recycle their own materials to survive, particularly under stress. Previous research has indicated autophagy is a key mechanism by which metastatic pancreatic cancer cells evade the immune system.

The first patients have been dosed in each cohort.

2021-11-03-REVOLUTION_Cohorts_Final_800x400.gif

This trial will also further explore biomarker data generated by the PRINCE study, aiming to better understand which patients stand to benefit from immunotherapy.

"This is an exciting next step in PICI’s and CRI’s commitment to deliver bold, science-driven ideas, and this trial shows how those efforts build on each other as the research progresses," said PICI researcher and CRI Scientific Advisory Council member Robert H. Vonderheide, MD, DPhil, director of the Abramson Cancer Center of the University of Pennsylvania and the study’s overall principal investigator. "REVOLUTION will make use of the same capabilities as PRINCE while adding a framework that can test and advance potentially promising combination therapies more efficiently than standard clinical trials."

REVOLUTION is also designed with the greater field in mind, building off PICI’s and CRI’s shared goals of breaking silos and creating efficiencies through collaboration. PICI has partnered with the Pancreatic Cancer Action Network (PanCAN) and its Precision PromiseSM phase 2/3 platform study in metastatic pancreatic cancer for exactly this purpose. If a cohort of REVOLUTION proves successful, it can be considered for further development under the Precision Promise umbrella. Once again, this accelerates the clinical trial process, ensuring potentially lifesaving therapies make their way to patients as quickly as possible. This partnership also advances CRI’s commitment to discovering and developing immune-based treatments that improve outcomes for all cancer patients, including those who face pancreatic and other hard-to-treat cancers.

In addition to Penn, sites on the trial include the Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, the University of California, San Francisco, the University of California, Los Angeles, the University of Texas MD Anderson Cancer Center, and Stanford Medicine.

Additional partners on the trial include the 1440 Foundation, Bristol Myers Squibb and PanCAN.

About Pancreatic Cancer
Pancreatic cancer is one of the deadliest types of tumors, and the number of diagnosed cases continues to rise each year. The disease is difficult to catch early, meaning by the time most people are diagnosed, their cancer is advanced and may have already spread. In addition, the tumors usually contain a variety of mutations, meaning one targeted therapy isn’t enough to stop the disease by itself. For patients who are diagnosed after cancer has spread to other parts of the body – a distinction that applies to more than half of all pancreatic patients – the 5-year survival rate is just three percent.

On November 3, 2021 QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) reported that results for the third quarter and first nine months of 2021 (Press release, Qiagen, NOV 3, 2021, View Source [SID1234594226]).

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In Q3 2021, net sales rose 11% (+10% at constant exchange rates, CER) to $535 million, which was well above the outlook for CER sales to be at the same level as in the year-ago period. Key drivers were a 48% CER gain in sales of the QuantiFERON-TB test to $79 million over Q3 2020 and solid growth in DNA sample technologies products. Also supporting the performance was a stronger-than-expected demand for COVID-19 testing solutions. Diluted earnings per share (EPS) were $0.57 in Q3 2021, up from $0.07 per share in the same period of 2020. Adjusted diluted EPS was $0.58 ($0.58 CER), which was above the outlook for $0.52-0.53 CER and unchanged from Q3 2020.

"QIAGEN’s results for the third quarter of 2021 confirm that our business continues to build strong momentum, especially our non-COVID product groups that delivered 17% CER growth," said Thierry Bernard, Chief Executive Officer of QIAGEN N.V. "We are on track to reach our 2021 sales targets for our five pillars of growth while crossing a significant milestone of more than $2 billion in net sales. Our performance during 2021 has underscored the relevancy of QIAGEN in the molecular research and testing market, while we stand ready to address the volatile trends in COVID-19 testing."

Roland Sackers, Chief Financial Officer of QIAGEN N.V., said: "We have upgraded our full-year outlook for 2021 to reflect the stronger-than-expected results in the third quarter of 2021. Using the boost from the COVID-19 pandemic demand, as well as the momentum in our non-COVID product groups, we are making significant progress on initiatives to support the business expansion in the coming years thanks to our record operating cash flow combined with a commitment to disciplined capital allocation. This has given us the flexibility to make investments to further accelerate our five pillars of growth while increasing returns to shareholders, such as through the recently completed $100 million share repurchase program."

Please find the full press release incl. tables here

Investor presentation and conference call

A conference call is planned for Thursday, November 4, 2021, at 14:30 Central European Time (CET) / 9:30 Eastern Daylight Time (EDT). A live audio webcast will be made available in the investor relations section of the QIAGEN website, and a replay will also be made available after the event. A presentation is available at View Source as of Thursday, November 4, 2021, at 12:30 Central European Time (CET) / 7:30 Eastern Daylight Time (EDT).

On November 3, 2021 Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, reported it will host a conference call to discuss the third quarter 2021 financial results and provide a corporate update on Wednesday, November 10, 2021 at 4:30 p.m. Eastern/1:30 p.m. Pacific (Press release, Spectrum Pharmaceuticals, NOV 3, 2021, View Source [SID1234594250]).

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The conference call will also be available from the Investor Relations section of the company’s website at View Source and will be archived there shortly after the live event.