BioStock: Strengthening quarter for Sprint Bioscience

On October 29, 2021 Sprint Bioscience reported the the third quarter was an intense and news-dense period (Press release, Sprint Bioscience, OCT 29, 2021, View Source [SID1234592191]). Thanks to a licensing agreement and a rights issue, the company now finds itself in its strongest financial position to date and ready to take the next step in its development. BioStock contacted CEO Erik Kinnman to get his view on the past quarter and on the future.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

With three outlicensed drug programs, with a combined potential value of 747 million USD, plus potential royalties, the future has a lot to offer Sprint Bioscience. The latest in the line of license deals is the immunooncology program Vps34. During the third quarter, the company worked intensely on handover to American Deciphera Pharmaceuticals, that is now taking over the helm in the program.

Solid base for continued investments
A brand new new license agreement and a completed rights issue mean that Sprint Bioscience stands at a cash position of 85.7 million SEK at the end of the third quarter, ready to invest further in new preclinical drug programs.

And the company has not been slow to make use of this. Shortly after Vps34 was outlicensed, the company announced the next addition to the internal development portfolio, NIMA. The goal of the project is to develop a treatment for solid cancerous tumours. The candidate aims to inhibit the tumour’s ability to program the microenvironment around it, thus preventing tumour growth and facilitating attacks from the immune system. You can read more about the program here.

Great interest in the development projects
In addition, progress has also been made in the DISA development program, where the intended target protein has been announced. In connection with this, the marketing of the program began, with intensified dialogues with potential licensees. A first stop on the marketing journey was the partnering conference BIO-Europe, which took place during the past week, where Sprint Bioscience was met with great interest in both DISA and other development programs.

In parallel with the escalating marketing of DISA, work is also ongoing to find new interesting starting points for more drug development programs. One such program is carried out in collaboration with Dr Julian Walfridsson at Karolinska Institutet, a program that was recently awarded a research grant of 2.5 million SEK from the Swedish Foundation for Strategic Research. Read more.

Björn Sjöstrand new Chairman of the Board
However, it was not only the coffers and portfolio that expanded during the quarter, Sprint Bioscience also took steps to strengthen the organisation. The company has appointed a new CFO in the form of Mattias Skalmstad and the board was joined by life science entrepreneur Björn Sjöstrand as its new chairman. You can read an interview with Sjöstrand where he talks about his entry into, and his view of, the company here.

CEO comments
Overall, it has been an eventful quarter for Sprint Bioscience. BioStock contacted the company’s CEO Erik Kinnman to get his view of the third quarter and to learn more about what he sees ahead as we move towards winter.

First of all, Erik, how would you like to sum up the past quarter?
– It’s been very intense and successful. We have outlicensed the VPS34 program to Deciphera Pharmaceuticals, a very strong partner that has already shown great commitment to taking the program further. This is our largest deal to date and together with the new share issue carried out in August, this means that we have greatly strengthened our financial position.

– With a strong financial position in place, we can look to the future and focus on continuing to develop the business and build values in both outlicensed and internal programs.

BIO-Europe was held this week, an important event for you where you had conversations about the DISA project. What is the interest in the project so far?
– There is a noticeable interest from a large number of different companies. Some are interested more generally in what we have to offer, others are more specifically interested in either the VADA or DISA programs. It is clear that the mechanisms we address are highly interesting. DISA is in the relatively early stages compared to the VADA programme and we have received valuable feedback and started new dialogues. The BIO-Europe meeting has been successful for us and provided us with good support for continued discussions and marketing of our pharmaceutical programs.

Looking ahead, what milestones do you see in the next year?
– We continue to work intensively with our partners and the outlicensed programs to reach the next milestone on the path to clinical development and market approval. Such successes will further validate our business model. Furthermore, we want to continue to build our internal portfolio of highly interesting cancer drug programs and we are constantly working to sign new licensing agreements with strong international partners.

The content of BioStock’s news and analyses is independent but the work of BioStock is to a certain degree financed by life science companies. The above article concerns a company from which BioStock has received financing.

Empowering Targeted Cancer Drug Discovery with AI and Novel Disease Models, Signet Therapeutics Raises ~$10 million in Seed-2 Round

On October 29, 2021 Signet Therapeutics, a biopharmaceutical startup focusing on developing innovative targeted cancer drugs using novel disease models, reported it has completed seed-2 round of approximately 10 million US dollars (Press release, Signet Therapeutics, OCT 29, 2021, View Source [SID1234592207]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The new round was led by 5Y Capital (Morningside Venture), with participation from Yael Capital, Blue Ocean Capital, and existing investors Tiantu Capital and Sky9 Capital. The new funding will advance Signet’s two first-in-class oncology programs toward clinical trials. In addition, Signet plans to expand its platform of disease models to other cancer areas and empower target discovery and pharmacodynamics studies at other pharmaceutical companies on a greater scale. Founded in 2020, Signet has raised a seed round of ¥60 million in CNY (equivalent to approximately $10 million), totaling two rounds of around $20 million within its first year.

Dr. Haisheng Zhang, CEO of Signet Therapeutics, and his core team members were from Dana-Farber Cancer Institute, Harvard Medical School, one of the world’s leading cancer research institutions. Traditional in vitro studies use cell lines that cannot accurately model patient’s drug performance, often returning misleading bioactivity results that misguide the screening and optimization of lead compounds, which could result in clinical failure. Leveraging years of oncology and functional biology and genomic research expertise, Signet developed a unique platform of novel disease models based on real-world cancer genomics data to simulate drug effects in 3D organ tissues that bear a closer resemblance to human biology and produce pharmacodynamics data with higher relevance to clinical performance.

Gastric cancer is the third leading cause of cancer death in the world. Close to one-third of the cases are of the diffusive gastric cancer (DGC) subtype, which is associated with poor prognosis and a low response rate to existing cancer therapies and medicines. Using its novel disease models platform, Signet made the groundbreaking discovery of a promising new target for DGC. It launched a drug discovery program with the leading AI drug R&D company XtalPi and, in March 2021, announced the identification of a pre-clinical candidate in over six months.

As Signet quickly advance its first-in-class DGC pipeline toward clinical trials, it has recently expanded its drug discovery program with XtalPi to another novel cancer target discovered by Signet. The two companies hope to build upon their existing success in combining XtalPi’s AI drug discovery capabilities with Signet’s customized novel disease models to quickly discover and validate candidates with potent bioactivity and a desirable drug property profile that can translate to enhanced clinical performance.

Kiniksa Pharmaceuticals to Report Third Quarter 2021 Financial Results on November 1, 2021

On October 29, 2021 Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA) reported that it will host a conference call and live webcast on Monday, November 1, 2021, at 8:30 a.m. Eastern Time to report its third quarter 2021 financial results and recent portfolio execution (Press release, Kiniksa Pharmaceuticals, OCT 29, 2021, View Source [SID1234593969]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live webcast will be accessible through the Investors & Media section of the company’s website at www.kiniksa.com. A replay of the webcast will also be available on Kiniksa’s website within approximately 48 hours of the event. The conference call can be accessed by dialing (866) 614-0636 (U.S. and Canada) or (409) 231-2053 (international) using conference ID number 1699563.

AbClone adds patent for AC101, stomach cancer and breast cancer treatment with improved stability

On October 29, 2021 AbClon reported an additional material patent had been acquired (Press release, AbClon, OCT 29, 2021, View Source;wr_id=151 [SID1234638631]). This patent AC101 This is a follow-up patent in which stability enhancement technology was additionally applied to the patent.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

AC101 Discovery used AbClone’s proprietary antibody discovery technology ‘NEST (Novel Epitope Screening Technology)’ The platform was utilized. This platform is a technology that newly discovers antibody binding sites on disease proteins, Antibody treatments developed through this process can exhibit different therapeutic effects depending on the epitope, so when a patent is acquired, it is different from other existing patented technologies targeting the same disease protein. It has the advantage of being relatively free.

This AC101’s follow-up patent has already been Separate from the existing AC101 patent registered in several countries, technology to improve stability has been applied, .Also, applications have been filed in the U.S. and Europe and examination is in progress. Japan, and Before China, registration was also completed in Korea, Australia

AC101is a disease protein HER2 (Human It is a monoclonal antibody treatment targeting Epidermal Growth Receptor 2). Herceptin, Perjeta, etc. HER2 Although it has been approved as a targeted antibody treatment, it is reported that treatments with strong anticancer effects are still rare in the treatment of stomach cancer.

AC101 was superior to Herceptin+Perjeta co-administration in animal models co-administered with Herceptin. It showed efficacy, this data shows that AbClone Shanghai Henrius Biotech(hereinafter referred to as Henrius)at AC101 was an opportunity to transfer technology.

Henlius targeted stomach cancer last 9month. AC101 (Henrius codename: HLX22) and Herceptin biopsy miller In the combination clinical trial2, administration to the first patient began. Through advanced clinical trial1phase 2Dosage(25mg/kg) It has been decided, to be clinically targeted as the first standard treatment for gastric cancer patients. 2award is in progress. According to these results, AppClone’s follow-up milestones and royalties will be determined. Additional profits are also expected.

Company officials said "AC101 with improved stability Stronger intellectual property rights were secured through additional patent registration" "In the future, through the commercialization of AC101, our company will also be available in the global market. NEST expects that its platform technology will be recognized" revealed.

Syros to Report Third Quarter 2021 Financial Results on Friday, November 5, 2021

On October 29, 2021 Syros Pharmaceuticals (NASDAQ:SYRS), a leader in the development of medicines that control the expression of genes, reported that it will host a live conference call and webcast at 8:30 a.m. ET on Friday, November 5, 2021 to report its third quarter 2021 financial results and provide a corporate update (Press release, Syros Pharmaceuticals, OCT 29, 2021, View Source [SID1234592192]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

To access the live conference call, please dial (866) 595-4538 (domestic) or (636) 812-6496 (international) and refer to conference ID 3287324. A webcast of the call will also be available on the Investors & Media section of the Syros website at www.syros.com. An archived replay of the webcast will be available for approximately 30 days following the presentation.