On September 15, 2021 Herantis Pharma Plc ("Herantis" or the "Company") reported its intention to issue new shares (the "Placing Shares") in a private placement to institutional and other qualified investors (the "Placing") to raise a minimum of EUR 4 million in gross proceeds (Press release, Herantis Pharma, SEP 15, 2021, View Source,c3415965 [SID1234587740]). The gross proceeds of the Placing may be higher than the planned preliminary minimum amount.

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The number of Placing Shares and their subscription price will be decided based on offers received in an accelerated book building. Swedbank AB (publ) ("Swedbank") is acting as the global coordinator and bookrunner of the Placing in association with Kepler Cheuvreux. The result of the Placing will be published by way of a company release after the completion of the book building. The book building will be launched immediately following the publication of this company release and the book building is expected to end by 8:30 p.m. CEST on 15 September 2021. The book building can be discontinued or extended at any time during the book building process.

Acme Investments SPF Sarl, a company controlled by Timo Syrjälä, and Nanoform Finland Plc ("Nanoform") have indicated their intention to participate in the Placing. In addition, Herantis is continuing its collaboration with Nanoform as previously disclosed.

The Placing will be carried out based on the authorisations given to the board of directors by the Company’s annual general meeting of 15 April 2021 and the extraordinary general meeting of 2 December 2020.

Subject to the completion of the Placing, the Placing Shares (ISIN code FI4000087861) will be registered with the trade register maintained by the Finnish Patent and Registration Office on or about 16 September 2021. The Placing Shares are expected to be ready for delivery to the investors against payment through Euroclear Finland Oy or, as applicable, through Euroclear Sweden AB on or about 20 September 2021. Trading in the Placing Shares is expected to commence on Nasdaq First North Growth Market Finland and Nasdaq First North Growth Market Sweden on or about 20 September 2021.

Reasons for the Placing and use of proceeds

Herantis intends to use the net proceeds from the Placing for the following purposes:

progressing development of rhCDNF and xCDNF (HER-096) to point of entering clinical development; and
general corporate purposes.
The Placing is expected to allow the Company to obtain needed financing on terms that, in the assessment of the Company, will be more beneficial than terms that would otherwise be available, and therefore weighty financial reasons exist for deviating from the pre-emptive rights of the shareholders.

Swedbank is acting as the global coordinator and bookrunner of the Placing in association with Kepler Cheuvreux. Krogerus Attorneys Ltd is acting as the legal counsel to the Company as to Finnish law and Borenius Attorneys Ltd is acting as the legal counsel to the global coordinator and bookrunner of the Placing as to Finnish law.

On September 15, 2021 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a clinical-stage targeted oncology company, reported that the Company will host a virtual Investor Event on Monday, September 20, 2021 at 8:30 a.m. ET / 5:30 a.m. PT (Press release, Mirati, SEP 15, 2021, View Source [SID1234587757]).

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Company executives will discuss:

A top-line update from the Phase 2 registrational cohort of the KRYSTAL-1 study in previously-treated patients with KRASG12C-mutated non-small cell lung cancer (NSCLC)
Findings from the colorectal cancer (CRC) cohort of the Phase 1/2 KRYSTAL-1 study evaluating adagrasib as monotherapy and in combination with cetuximab in patients with heavily pretreated CRC harboring the KRASG12C mutation, as presented at the 2021 European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress
Results from the Phase 2 MRTX-500 study evaluating sitravatinib combined with nivolumab in patients with non-squamous NSCLC who progressed on or after prior checkpoint inhibitor therapy, to be presented at the 2021 ESMO (Free ESMO Whitepaper) Congress
Investors and the general public are invited to register and listen to a live webcast of the event through the "Investors and Media" section on Mirati.com. A replay of the event will be available shortly after the conclusion of the event.

Mirati studies at ESMO (Free ESMO Whitepaper) Congress 2021 include:
*All times noted are Central European Summer Time (CEST)

Presentation Title: KRYSTAL-1: Adagrasib (MRTX849) as Monotherapy or Combined with Cetuximab in Patients With Colorectal Cancer Harboring a KRASG12C Mutation
Author: Jared Weiss
Abstract Number: LBA6
Session: Presidential Symposium II
Presentation Date/Time: Sunday, September 19, 2021 at 15:47-16:02 CEST | Channel 1

Presentation Title: MRTX-500: Phase 2 Trial of Sitravatinib (Sitra) + Nivolumab (Nivo) in Patients (Pts) With Nonsquamous (NSQ) Non–Small-Cell Lung Cancer (NSCLC) Progressing on or After Prior Checkpoint Inhibitor (CPI) Therapy
Author: Ticiana A. Leal
Abstract Number: 1191O
Session: NSCLC Proffered Paper Session II
Presentation Date/Time: Monday, September 20, 2021 at 14:10-14:20 CEST | Channel 4

On September 15, 2021 Obsidian Therapeutics, a biotechnology company pioneering engineered cell and gene therapies, reported that the Company will present data highlighting its cytoTIL15 program at the upcoming European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress, which will be hosted virtually September 16-21, 2021 (Press release, Obsidian Therapeutics, SEP 15, 2021, View Source [SID1234587780]).

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The abstract for the poster describes how Obsidian’s cytoTIL15 product (TIL engineered with membrane-bound IL15, or mbIL15) demonstrates enhanced in vitro potency and phenotype and in vivo persistence in the absence of IL-2, paving the way for more durable efficacy and improved safety in patients with solid tumor malignancies. The abstract has been published in ESMO (Free ESMO Whitepaper) Immuno-Oncology Congress 2021 Abstract Book.

Details of the poster presentation:
Title: cytoTIL15: A novel TIL therapy for melanoma with superior potency and enhanced persistence without IL2 to improve safety & efficacy and expand patient eligibility
Abstract Number: 1008P
Session: Investigational Immunotherapy
Abstract Summary: Tumor-infiltrating lymphocytes (TILs) have generated promising data in clinical trials as therapy for heavily pretreated patients with solid tumor malignancies, such as metastatic melanoma. TIL therapy currently requires IL2 for in vivo maintenance of TILs, significantly limiting its application due to patient safety and eligibility hurdles. Obsidian’s cytoTIL product is comprised of TILs engineered with mbIL15 that is regulatable using a drug responsive domain (DRD) designed via our cytoDRiVE platform. Our cytoTIL15 product displays a favorable cytotoxic CD8+ T cell phenotype while maintaining TCR Vbeta repertoire diversity during manufacturing. cytoTIL15 exhibit superior in vitro anti-tumor cytotoxicity as well as polyfunctionality, compared to conventional TILs + IL2. In vivo, cytoTIL15 demonstrate greater antigen-independent expansion and persistence compared to conventional TILs treated with IL2.

Jan ter Meulen, M.D., Ph.D., Chief Scientific Officer of Obsidian, commented, "We are very excited about the superior persistence and cytotoxicity profile exhibited by cytoTIL15 in our preclinical models, and are eager to continue to advance our mission to translate these benefits to patients with metastatic melanoma and other solid tumor malignancies."

About cytoTIL15
cytoTIL15 is Obsidian’s lead cytoTIL program, currently in preclinical development for the treatment of patients with metastatic melanoma and other solid tumors. cytoTIL15 is a novel engineered tumor infiltrating lymphocyte therapy engineered with regulated membrane-bound IL15 that does not require patients to receive concomitant IL2 therapy, a toxic and costly requirement for conventional TILs. The Company expects to submit an IND for cytoTIL15 in mid-2022.

On September 15, 2021 Cerus Corporation (Nasdaq: CERS) reported that William ‘Obi’ Greenman, Cerus’ president and chief executive officer, and Kevin D. Green, Cerus’ chief financial officer, are scheduled to participate in the 2021 Cantor Global Virtual Healthcare Conference on Wednesday, September 29, 2021 at 11:20 a.m. ET (Press release, Cerus, SEP 15, 2021, View Source [SID1234587725]).

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A live webcast of the presentation will be available on Cerus’ Investor Relations page at View Source A replay of the webcast will be available for approximately two weeks following the completion of the event.

On September 15, 2021 Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) reported that Lonnel Coats, Lexicon’s president and chief executive officer, will present virtually at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit on Tuesday, September 21, 2021 at 10:45 a.m. ET (Press release, Lexicon Pharmaceuticals, SEP 15, 2021, View Source [SID1234587741]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A webcast of the event will be available in the "Events" section of the Lexicon website at www.lexpharma.com. An archived version of the webcast will be available on the website for two weeks.