On September 13, 2021 Cytovia Therapeutics, Inc. ("Cytovia"), a biopharmaceutical company developing allogeneic "off-the-shelf" gene-edited iNK and CAR (Chimeric Antigen Receptor)-iNK cells derived from induced pluripotent stem cells (iPSCs) and NK cell engager multifunctional antibodies, and CytoLynx Therapeutics ("CytoLynx), its newly-formed China-focused joint venture, reported that they have closed $45 million from institutional investors to finance the IND enabling and initial clinical development of their pipeline (Press release, Cytovia Therapeutics, SEP 13, 2021, View Source [SID1234587918]).

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Cytovia and TF Capital, a leading China-based biotech institutional investor, have formed CytoLynx Therapeutics. TF Capital along with YF Capital, BioTrack Capital, Ruihua Capital, and TG Sino-Dragon Fund (backed by TigerMed) have invested $45 million to support the new venture, as well as Cytovia research and development projects. The collaboration agreements between CytoLynx and Cytovia will advance multiple NK therapeutics through product development in the Greater China region. Additionally, CytoLynx obtained a technology license from Cytovia based on its core technologies to allow in-China development of additional NK therapeutics for global commercialization. Cytovia is eligible to receive up to $400 million in upfront development and commercial milestones under the agreement.

Dr. Daniel Teper, Chairman and CEO of Cytovia commented: "We are excited to accelerate the global development of our lead GPC3 programs for the treatment of hepatocellular carcinoma, a condition with significant unmet medical needs and a very large patient population in Asia, particularly in China, and establish a path to provide these therapies to the Chinese market. CytoLynx will also serve as a development and commercialization platform for additional Cytovia products, as well as in-licensed immuno-oncology assets."

Dr. Wei Cheng, Managing Director at TF Capital added: "We are delighted to partner with Cytovia Therapeutics to bring novel therapeutic options to patients in China. Cytovia has a seasoned entrepreneurial leadership team and best-in-class NK technologies, including iPSC-derived NK cells, gene editing, and NK Engager multifunctional antibodies. We believe that by combining the strengths of the two parties, we can make CytoLynx and Cytovia global leaders in NK cancer therapeutics and benefit patients worldwide."

Dr. Albert Huang, Executive Director at Yunfeng Capital noted: "As the lead investor in this series of financing, Yunfeng Capital believes that Cytovia and CytoLynx are well positioned to become leading players in iPSC NK cell therapy."

On September 13, 2021 Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, reported a late-breaking presentation of early poziotinib efficacy and safety data in first-line patients with non-small cell lung cancer (NSCLC) with HER2 exon 20 mutations from cohort 4 of the ZENITH20 clinical trial at the upcoming European Society for Medical Oncology Congress (ESMO) (Free ESMO Whitepaper) 2021 that will take place virtually September 16-20, 2021 (Press release, Spectrum Pharmaceuticals, SEP 13, 2021, View Source [SID1234587589]).

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Details of the ESMO (Free ESMO Whitepaper) presentation are as follows:

Title: Efficacy and safety of poziotinib in treatment-naïve NSCLC harboring HER2 exon 20 mutations: A multinational Phase 2 study (ZENITH20-4)
Speaker: Robin Cornelissen, MD, PhD, Erasmus MC Cancer Institute, Department of Pulmonology, Rotterdam, The Netherlands
Session: Proffered Paper session – NSCLC, metastatic 1
Location: Channel 1
Date and Time: September 18, 2021 from 2:20-2:30 p.m. CEST
Presentation Number: LBA46
Abstract Number: 2581

The presentation will be available for viewing by registered participants during the conference via the ESMO (Free ESMO Whitepaper) website on September 18, 2021.

About the ZENITH20 Clinical Trial

The ZENITH20 study consists of seven cohorts of NSCLC patients. Cohorts 1 (EGFR) and 2 (HER2) in previously treated NSCLS patients with exon 20 mutations and Cohort 3 (EGFR) in first-line patients have completed enrollment. Cohort 4 (HER2) in first-line NSCLC patients with exon 20 mutations is still enrolling patients. Cohorts 1- 4 are each independently powered for a pre-specified statistical hypothesis and the primary endpoint is objective response rate (ORR). Cohort 5 includes previously treated or treatment-naïve NSCLC patients with EGFR or HER2 exon 20 insertion mutations. Cohort 6 includes NSCLC patients with classical EGFR mutations who progressed while on treatment with first-line osimertinib and developed an additional EGFR mutation. Cohort 7 includes NSCLC patients with a variety of less common mutations in EGFR or HER2 exons 18-21 or the extracellular or transmembrane domains.

On September 13, 2021 Labcorp (NYSE: LH), a leading global life sciences company, reported that it has closed its acquisition of select operating assets and intellectual property (IP) from Myriad Genetics’ autoimmune business unit, including the Vectra rheumatoid arthritis (RA) assay (Press release, LabCorp, SEP 13, 2021, View Source [SID1234587606]).

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Earlier this year, Labcorp entered into a definitive agreement to acquire Myriad’s Vectra test, related IP and other RA assets, bolstering its scientific leadership in rheumatology. Specific terms of the transaction were not disclosed.

On September 13, 2021 XOMA Corporation (NASDAQ: XOMA) reported its Chief Executive Officer, Jim Neal, will present at the H.C. Wainwright 23rd Annual Global Investment Virtual Conference held on September 13-15, 2021 (Press release, Xoma, SEP 13, 2021, View Source [SID1234587623]). The presentation will be available on demand beginning September 13, 2021, at at 7:00 AM ET and can be accessed at https://bit.ly/2X7bWb0. The presentation can also be accessed by visiting the investor relations section of the Company’s website at www.xoma.com. A replay of the presentation will be available and archived on the site for 90 days after the event.

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On September 13, 2021 Inhibrx, Inc. (NASDAQ: INBX), a clinical-stage biotechnology company focused on developing a broad pipeline of novel biologic therapeutic candidates, reported that the Company will be presenting at the following upcoming virtual investor conference (Press release, Inhibrx, SEP 13, 2021, View Source [SID1234587639]):

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2021 Cantor Virtual Global Healthcare Conference; Wednesday, September 29th, at 8:40 a.m. Pacific Time
The investor conference presentation will be webcast live and may be accessed through a link on the investors section of Inhibrx’s website at View Source The webcast will be available for 60 days following the event.