On October 12, 2021 Biognosys, a leader in next-generation proteomics solutions for drug discovery and development, reported that it is supporting Cancer Scout as Proteomics provider (Press release, Biognosys, OCT 12, 2021, View Source [SID1234591113]).

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Cancer Scout is a large-scale joint research project led by University Medical Center Göttingen and Siemens Healthineers. The project received funding of EUR 10 million by the German Federal Ministry of Education and Research (BMBF)1.

The objective of Cancer Scout is to provide a new Artificial Intelligence tool for precision medicine in the fight against cancer. The research project will analyze and combine genomics, proteomics, and pathology data through Artificial Intelligence to generate a "digital biopsy" of molecular changes in tumors. Identifying these molecular changes can support early and accurate cancer diagnosis and predict personalized therapies for a patient’s tumor.

Oliver Rinner, PhD, CEO and founder of Biognosys states: "We are excited to be part of this visionary multi-omics research project and contribute to the development of more personalized clinical diagnostics and therapies for cancer with our proteomics solutions."

Biognosys was selected as the provider for the Proteomics data analysis in Cancer Scout, based on its unique technologies and workflows for large-scale proteomics, comprehensive quality standards for clinical research, and extensive expertise in precision oncology.

Biognosys’ discovery proteomics platform utilizes proprietary, patented Hyper Reaction Monitoring (HRM) mass spectrometry technology to quantify complete proteomes with unmatched precision, depth, and reproducibility. This solution can be applied with high throughput in large-scale studies involving thousands of samples from a broad range of clinical sample types.

Professor Philipp Ströbel, Director of Pathology at the University Hospital Göttingen, comments: "Combining digital pathology with proteomics and other omics data is essential to identify the full spectrum of molecular changes in tumors and enable truly personalized cancer care."

Christian Wolfrum, Head of New Business Development and Planning at Siemens Healthineers, adds: "We are excited to work with Biognosys to generate novel scientific insights in Cancer Scout and translate these into personalized cancer care solutions for clinical practice."

On October 12, 2021 4D pharma plc (AIM: DDDD, NASDAQ, LBPS), a pharmaceutical company leading the development of Live Biotherapeutic products (LBPs), a novel class of drug derived from the microbiome, reported that 4D management will present at the Jefferies Virtual Next Generation IBD Therapeutics Summit being held on October 19, 2021 (Press release, 4d Pharma, OCT 12, 2021, View Source [SID1234591114]).

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A webcast of the presentation will be available on the ‘Events’ section of the 4D pharma website at www.4dpharmaplc.com beginning Tuesday, October 19, 2021 at 8:00 a.m. ET (1:00 p.m. BST).

On October 12, 2021 Kytopen reported that 2021 Cell & Gene Meeting on the Mesa, organized by the Alliance for Regenerative Medicine, was a hybrid event held in-person in Carlsbad, CA on October 12 -14th and virtually on October 19th & 20th (Press release, Kytopen, OCT 12, 2021, View Source;utm_medium=rss&utm_campaign=kytopen-presents-at-the-2021-cell-gene-meeting-on-the-mesa [SID1234594172]). Tackling the commercialization hurdles facing the cell and gene therapy sector today, this meeting covers a wide range of topics from clinical trial design to alternative payment models to scale-up and supply chain platforms for advanced therapies.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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In this year company presentation, Kytopen provided a case study of our Flowfect non-viral transfection platform for ex vivo cell therapy discovery and manufacturing. The study in CD34+ stem cells & mRNA highlights our tiered approach to optimize payload and transfection parameters while confirming the robustness of the process despite donor variability and scale up for clinical relevance. In just 6 weeks, we scaled our process to transfect 200x more CD34+ stem cells in seconds while maintaining significantly high levels of cell recovery, viability, and efficiency.

The Flowfect platform is a transformative solution that eliminates the complexity of scale up in cell engineering in one flexible scalable solution. Our goal is to reduce risk while providing maximum control and flexibility to drive higher yields, faster approvals, and better outcomes for curative cellular disease treatment.

ARM’s 2021 Meeting on the Mesa attracted more than 1,700 registrants this year, including nearly 1,200 attendees at the in-person portion of the conference in Carlsbad, CA. With an approximately 40% increase in the number of registrants from 2019 and 2020, this year’s meeting was the largest in ARM’s history. The conference featured three days of live panels and presentations, as well as additional on-demand content and nearly 3,000 virtual and in-person partnering meetings.

On October 12, 2021 Eli Lilly and Company (NYSE: LLY) reported that it will announce its third-quarter 2021 financial results on Tuesday, October 26, 2021 (Press release, Eli Lilly, OCT 12, 2021, View Source [SID1234591099]). Lilly will also conduct a conference call on that day with the investment community and media to further detail the company’s financial performance.

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The conference call will begin at 9 a.m. Eastern time. Investors, media and the general public can access a live webcast of the conference call through a link that will be posted on Lilly’s website at View Source A replay will also be available on the website following the conference call.

On October 12, 2021 CG Oncology, Inc., a clinical-stage biotechnology company focused on developing oncolytic immunotherapies for patients with advanced cancer, reported that acceptance of an oral presentation and a poster presentation at The Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting, held virtually and in-person in Washington, DC, November 10-14, 2021 (Press release, CG Oncology, OCT 12, 2021, View Source [SID1234591115]).

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CG Oncology will present preliminary safety and efficacy data from CORE1, an ongoing Phase 2 clinical trial of CG0070 in combination with KEYTRUDA (pembrolizumab), for the treatment of patients with Non-Muscle-Invasive Bladder Cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG).

Under a previously announced clinical collaboration with Merck relating to the investigation of CG0070 used in combination with pembrolizumab, the goal of CORE1, which will enroll up to 35 patients, is to evaluate the safety and efficacy of CG0070 plus KEYTRUDA for the treatment of NMIBC unresponsive to BCG.

More information about the study can be found at www.clinicaltrials.gov (NCT04387461).

Details of the oral presentation are as follows:

CORE1: Phase 2, Single Arm Study of CG0070 Combined with Pembrolizumab in Patients with Non Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)
Abstract Number: 955
Presenter: Roger Li, M.D., Moffitt Cancer Center
Session Date & Time: Saturday, November 13, 2021 from 12:15-12:30pm EST
Category: Late-Breaking Oral Abstract Session

In addition, CG Oncology will present an overview of trial design and methodology of BOND3, an ongoing global Phase 3 trial with CG0070 as a monotherapy for the treatment of patients with NMIBC unresponsive to BCG. The goal of BOND3, which will enroll 110 patients, is to evaluate the safety and efficacy of CG0070 as a monotherapy for the treatment of NMIBC unresponsive to BCG.

More information about the study can be found at www.clinicaltrials.gov (NCT04452591).

Details of the poster presentation are as follows:

A phase 3, single-arm study of CG0070 in subjects with non-muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG)
Abstract Number: 426
Presenter: Edward Uchio, M.D., UC Irvine Health, Department of Urology
Session Date & Time: Friday, November 12, 2021 and Saturday, November 13, 2021 from 7:00am-8:30pm EST
Category: Poster Abstract Session

Full abstracts of both presentations will be available on the SITC (Free SITC Whitepaper) website on November 10, 2021.