On September 9, 2021 PerkinElmer, Inc. (NYSE: PKI), a global leader committed to innovating for a healthier world, announced today that it has priced an offering of $500.0 million aggregate principal amount of 0.550% Senior Notes due 2023 at an issue price of 99.964% of the principal amount, $800.0 million aggregate principal amount of 0.850% Senior Notes due 2024 at an issue price of 99.938% of the principal amount, $500.0 million aggregate principal amount of 1.900% Senior Notes due 2028 at an issue price of 99.928% of the principal amount and $500.0 million aggregate principal amount of 2.250% Senior Notes due 2031 at an issue price of 99.697% of the principal amount (Press release, PerkinElmer, SEP 9, 2021, View Source [SID1234587457]).

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The issuance of the notes is expected to close on September 10, 2021, subject to the satisfaction of customary closing conditions. The notes will pay interest on a semi-annual basis.

PerkinElmer plans to use the net proceeds of the offering to pay a portion of the cash consideration payable for its planned acquisition of BioLegend, Inc.

The joint book-running managers for the offering are Goldman Sachs & Co. LLC, BofA Securities, Inc., J.P. Morgan Securities LLC and Wells Fargo Securities, LLC.

The offering is being made pursuant to an effective registration statement on Form S-3 (including a prospectus) filed with the U.S. Securities and Exchange Commission ("SEC"). Prospective investors should read the prospectus forming a part of that registration statement and the prospectus supplement related to the offering and the other documents that PerkinElmer has filed with the SEC for more complete information about the company and this offering. These documents are available at no charge by visiting EDGAR on the SEC website at www.sec.gov. Alternatively, copies of the prospectus supplement and the accompanying prospectus relating to the offering can be obtained by calling one of the joint book-running managers at the following: Goldman Sachs & Co. LLC at 1-866-471-2526 or by emailing [email protected], BofA Securities, Inc. toll-free at 1-800-294-1322, J.P. Morgan Securities LLC collect at 1-212-834-4533 or Wells Fargo Securities, LLC toll-free at 1-800-645-3751.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy the notes, nor shall there be any offer, solicitation or sale of the notes in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

On September 9, 2021 Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, reported a broad-based research collaboration with Boehringer Ingelheim International GmbH to use Twist’s proprietary antibody libraries to discover therapeutic antibodies against multiple targets provided by Boehringer Ingelheim (Press release, Boehringer Ingelheim, SEP 9, 2021, View Source [SID1234587473]).

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"Boehringer Ingelheim believes Twist’s ability to generate potent, diverse therapeutic antibodies by mining its comprehensive libraries, combined with our extensive capabilities and experience in drug discovery and development, will enable us to deliver breakthrough opportunities to patients," said Clive R. Wood, Ph.D., Senior Corporate Vice President and Global Head of Discovery Research at Boehringer Ingelheim. "We look forward to working with Twist on molecular targets in a broad range of disease areas," added Wood.

Under the terms of the agreement, Twist Biopharma, a division of Twist, will utilize its "Library of Libraries," a panel of synthetic antibody phage display libraries derived only from sequences that exist in the human body, to identify potential therapeutic antibody candidates. Twist and Boehringer Ingelheim will work together to validate and optimize any resulting new antibody candidates, which could be researched against a range of therapeutic areas. Boehringer Ingelheim retains exclusive worldwide rights to develop and commercialize any therapeutic antibodies discovered as part of the collaboration.

Twist will receive an upfront payment for each program entry. In addition, Twist has the potential to earn up to a total of $710 million in success-based clinical, regulatory and commercial milestone payments for the multiple target discovery programs.

"This discovery collaboration with Boehringer Ingelheim covering numerous targets truly illustrates the power of our antibody libraries. We have the ability to generate precise antibodies to a diverse range of targets, which together with Boehringer Ingelheim’s strength in drug development capabilities, could mean multiple new, more personalized treatments in the future for patients," said Emily M. Leproust, Ph.D., CEO and co-founder of Twist.

On September 9, 2021 PharmaCyte Biotech presented Corporate presentation (Presentation, PharmaCyte Biotech, SEP 9, 2021, View Source [SID1234587523]).

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On September 9, 2021 Acorda Therapeutics, Inc. reported a corporate restructuring to reduce costs and more closely align operating expenses with expected revenue (Press release, Acorda Therapeutics, SEP 9, 2021, View Source [SID1234587460]). The Company also announced changes to its management team.

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Corporate Restructuring

As a result of the restructuring, the Company is reducing headcount by 15%. Most of the reduction in personnel will take place immediately, with the balance completed in the first quarter of 2022.

The Company expects to realize annualized cost savings of approximately $20 million from the headcount reductions and the outsourcing of certain operations, beginning in 2022. Acorda estimates that it will incur approximately $3.0 million of pre-tax charges for severance and other costs related to the restructuring, through the first quarter of 2022.

Management Changes

Lauren Sabella, currently Acorda’s Chief Commercial Officer, has been named Chief Operating Officer. She will have responsibility for Quality, Information Technology, Technical Operations, and Business Operations / Strategic Planning. Kerry Clem, Acorda’s Executive Vice President of Sales, Market Access, and Operations, has been named Chief Commercial Officer.

"We have made substantial progress over the past year, growing sales of Inbrija, maintaining Ampyra revenue to a substantial degree, and retiring our short-term debt. We have achieved these outcomes despite the significant impact of the pandemic on our business. When the pandemic subsides, we believe that we will have the opportunity to accelerate Inbrija’s trajectory, as in-person interactions with health care providers and patients return to more normal levels. The headcount reductions and structural changes we have made will enable us to operate more efficiently and further align our expenses with revenue, while continuing to grow Inbrija sales," said Ron Cohen, M.D., Acorda’s President and Chief Executive Officer. "We are deeply grateful to the associates who are leaving Acorda for their commitment, hard work, and many contributions."

September 9, 2021 Boston Scientific Corporation reported that it will host a meeting with the investor community to review its financial goals and long-term growth strategies on Wednesday, September 22, 2021, from 8:30 a.m. – 12:30 p.m. EDT (Press release, Boston Scientific, SEP 9, 2021, View Source [SID1234587476]). Company leaders will also provide business unit market overviews, pipeline updates and spotlight key products from the company’s Cardiovascular, MedSurg and Rhythm and Neuro segments.

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The meeting will be held in hybrid format, live in Boston as well as a simultaneous webcast. Investors and other interested parties may register for the live meeting or webcast by visiting the events and presentations section on the company’s investor website at View Source A replay and summary materials from the presentations will also be available online for approximately one year following the event.