On May 25, 2021 Defence Therapeutics reported the completion of its AccuVAC-D001 cancer vaccine preclinical study (Press release, Defence Therapeutics, MAY 25, 2021, View Source [SID1234626234]). The AccuVAC-D001 cancer vaccine demonstrated a 70% cure rate of mice with pre-established solid tumors, this AccuVAC-D001 cancer vaccine confirms an effective antitumoral response.

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Non-specific degradation of endocytosed cancer antigens by endo-lysosomal organelles in dendritic cells (DCs) is a major limitation in the field of cancer vaccination. Defence AccuVACTM addresses this with its engineered novel antigen formulation. The AccuVACTM protects endocytosed antigen from non-specific endosomal degradation by promoting its escape via endosomal membrane disruption. As such, endocytosed antigens accumulate – in their closest native state – in the cytosol of DC cells consequently resulting in efficient antigen crosspresentation to responding immune cells.

AccuVACTM dramatically improved protein processing and cross-presentation by ex vivo developed monocyte-derived DCs, which elicited potent CD4 and CD8 T-cell responses compared to the use of naked antigen. The net outcome culminates into effective anti-tumoral responses curing 70% of animals with pre-established solid tumors.

"The solid results of the AccuVACTM study demonstrates how this strategy can be positively adapted to engineered universal DC vaccines. This puts Defence and its technology on the path for future development of universal therapeutic vaccines for cancer and infectious diseases vaccines", says Mr. Plouffe, CEO of Defence Therapeutics.

Vaccines Market Size 2021, is Projected to Reach USD $104.87 Billion by 2027, exhibiting a CAGR of 10.7% according to Future Business Insights.

On May 25, 2021 Acacia Pharma Group plc ("Acacia Pharma", the "Group" or the "Company") (EURONEXT: ACPH), a commercial-stage biopharmaceutical company focused on developing and commercializing novel products to improve the care of patients undergoing serious medical treatments such as surgery, invasive procedures, or chemotherapy, reported that management will present a corporate overview at the Jefferies Virtual Healthcare Conference on Tuesday, 1 June 2021 at 08:00 ET (14:00 CEST) (Press release, Acacia Pharma, MAY 25, 2021, View Source [SID1234580527]).

A replay of the presentation will be available on the Jefferies conference website to registered conference attendees for 30 days post the event. Presentation slides will also be made available after the event through the investor section (Financial Reports and Presentations) of the Company’s website, www.acaciapharma.com.

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On May 25, 2021 INOVIO (NASDAQ:INO) a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, cancer, and HPV-associated diseases, reported that Dr. Joseph Kim, President and CEO, is scheduled to participate in a fireside chat and 1×1 investor meetings at the Jefferies 2021 Virtual Healthcare Conference on Tuesday, June 1, 2021 at 2:00 PM EDT (Press release, Inovio, MAY 25, 2021, View Source [SID1234580544]). A webcast of the event will be available at this link: View Source

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About INOVIO’s DNA Medicines Platform

INOVIO has 15 DNA medicine clinical programs currently in development focused on HPV-associated diseases, cancer, and infectious diseases, including coronaviruses associated with MERS and COVID-19 diseases being developed under grants from the Coalition for Epidemic Preparedness Innovations (CEPI) and the U.S. Department of Defense. DNA medicines are composed of optimized DNA plasmids, which are small circles of double-stranded DNA that are synthesized or reorganized by a computer sequencing technology and designed to produce a specific immune response in the body.

INOVIO’s DNA medicines deliver optimized plasmids directly into cells intramuscularly or intradermally using INOVIO’s proprietary hand-held smart device called CELLECTRA. The CELLECTRA device uses a brief electrical pulse to reversibly open small pores in the cell to allow the plasmids to enter, overcoming a key limitation of other DNA and other nucleic acid approaches, such as mRNA. Once inside the cell, the DNA plasmids enable the cell to produce the targeted antigen. The antigen is processed naturally in the cell and triggers the desired T cell and antibody mediated immune responses. Administration with the CELLECTRA device ensures that the DNA medicine is efficiently delivered directly into the body’s cells, where it can go to work to drive an immune response. INOVIO’s DNA medicines do not interfere with or change in any way an individual’s own DNA. The advantages of INOVIO’s DNA medicine platform are how fast DNA medicines can be designed and manufactured; the stability of the products, which do not require freezing in storage and transport; and the robust immune response, safety profile, and tolerability that have been observed in clinical trials.

With more than 3,000 patients receiving INOVIO investigational DNA medicines in more than 7,000 applications across a range of clinical trials, INOVIO has a strong track record of rapidly generating DNA medicine candidates with potential to meet urgent global health needs.

On May 25, 2021 Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, reported that Jack Khattar, President and CEO of Supernus Pharmaceuticals, will present a company overview at the Jefferies Virtual Healthcare Conference on Tuesday, June 1, 2021, at 1:30 p.m. ET (Press release, Supernus, MAY 25, 2021, View Source [SID1234580560]).

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A live webcast of the presentation can be accessed by visiting Events & Presentations in the Investor Relations section on the Company’s website at www.supernus.com. An archived replay will be available for 60 days on the Company’s website following the conference.

On May 25, 2021 Cellaria Inc (Wakefield, MA, USA), a scientific innovator with breakthrough tools for cancer research, now offers five stable, reported that fully authenticated lung cancer cell models to support the development of more effective and targeted drug therapies (Press release, Cellaria, MAY 25, 2021, View Source [SID1234580576]). Lung cancer was responsible for around 1.80 million deaths globally in 20201, more than any other cancer, making it an important area of clinical research. Each Cellaria model is securely linked to a well-defined patient tumor enabling the in vitro study of disease progression and drug response in a specific patient biology with defined genetic and epigenetic characteristics. Such studies accelerate progress towards better therapies for specific patient populations.

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Cellaria’s lung cancer cell models are all derived from tumors associated with non-small cell lung cancer (NSCLC), which accounts for around 85% of lung cancer cases. In recent years considerable progress has been made towards optimizing treatment for different subtypes of NSCLC with the targeting of specific genetic mutations proving particularly productive. Cellaria’s new lung cancer models – Bastion, Boulder, Pincer and Throne – join Jacket (an existing model), to provide a diverse patient cohort for the extension of such studies. All the patients within the cohort were over 60 years of age and had a history of smoking, but they exhibited notable, clinically significant differences including:

Documented variation in consumption and duration of smoking
Comorbidities – Throne had a previous diagnosis melanoma
Throne and Jacket have a KRAS genetic mutation, Pincer, Boulder and Bastion did not.
All Cellaria models are extremely stable and supplied with a Certificate of Analysis, to support optimal application. In addition, Cellaria produces drug response reports showing data for three baseline relevant treatments. For the lung cancer cohort this report includes results for etoposide and cisplatin and for two targeted treatments: 1) larotrectinib which is prescribed for patients with a neurotrophic receptor tyrosine kinase (NRTK) gene fusion and 2) erlotinib, which is prescribed for patients with a KRAS mutation. Detailed information such as this makes it straightforward to use Cellaria models effectively from the outset to implement reproducible and relevant research and maximize the benefit of in vitro studies.

"With the increase in availability of targeted therapeutics like larotrectinib and erlotinib, patient-specific models are adding essential utility," comments David Deems President and Founder, Cellaria Inc. "Jacket has mutations that make the patient a candidate for either larotrectinib or erlotinib. This unique patient-derived model enables the interrogation of each drug’s performance with the model to determine differences."

To find out more about the new lung cancer models view our product overviews here.

1 WHO Cancer Fact Sheet Detail. 3rd March 2021. Available to view at: View Source