On August 25, 2021 Patrys reported its Annual Report for the 2020-2021 Financial Year (FY21) (Press release, Patrys, AUG 25, 2021, View Source [SID1234586882]).

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Highlights include:

2020

Expansion of deoxymab portfolio with the addition of full sized IgG antibody, PAT-DX3
First patent granted for deoxymab-nanoparticles
Capital raising of $7.3m via a Placement and Rights Issue
2021

Successful development and selection of an optimised stable cell-line for commercial scale production of clinical grade PAT-DX1
New United States patent granted for Patrys’ deoxymab assets
Completion of animal pharmacokinetic studies for both PAT-DX1 antibody fragment and full-sized PAT-DX3 IgG antibody
Announcement of a collaborative research program with Imagion Biosystems Limited to improve brain tumor imaging and diagnosis
Publication of preclinical data, from collaboration with Yale School of Medicine demonstrating the ability of PAT-DX1 to cross the blood-brain barrier (BBB) and significantly inhibit the growth of both primary and secondary cancers in the brain in animal models

On August 25, 2021 Iotron Medical Inc. (Iotron) and Canadian Isotope Innovations Corp. (CIIC) reported a collaboration to produce the radioisotope copper-67 (Cu-67) for new cancer therapies (Press release, Iotron Medical, AUG 25, 2021, View Source;a-new-collaboration-to-produce-copper-67-301362227.html [SID1234586898]). This investment will increase the production capacity of the CIIC-operated facilities in Saskatoon, making Cu-67 more widely available to international cancer researchers.

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Iotron Medical, a spin-out business of Iotron Industries, has been providing innovative solutions using electron beam technology for more than 25 years. CIIC is a startup company, producing medical radioisotopes using a novel linear accelerator-based method initially developed at the Canadian Light Source.

Cu-67 has long been known for its excellent properties for personalized cancer therapy but has been extremely difficult to produce with sufficient quantity and purity using nuclear reactors or cyclotrons. Lack of an adequate and reliable supply of this radioisotope has prevented medical researchers from exploring the potential of Cu-67 in new targeted cancer therapies.

"Iotron is excited about the future for Cu-67 and the opportunity to work with CIIC to make the benefits of this radioisotope available to the wider market, and positively impact the lives of so many people," said Mike Scott, Iotron Board Chair.

CIIC and Iotron are proud to establish the world’s first private sector producer and supplier of this valuable radioisotope, building on the application innovations and accelerator expertise of both parties. This novel production method for high purity Cu-67 is needed by researchers and pharmaceutical companies developing new drugs for a variety of cancers including neuroendocrine tumors, prostate and neuroblastoma. When linked to a suitable targeting agent, Cu-67 delivers highly localized radiation to tumor cells.

"CIIC looks forward to working with our partner Iotron to bring this important radioisotope to market and to produce it in the volume needed for researchers and the broader pharmaceutical community," said Dr. Mark de Jong, Chief Technical Officer of CIIC.

Iotron and CIIC have committed to a five-year agreement that will establish a stable and reliable source of Cu-67, with plans to expand production further as market demand grows. The first shipments of Cu-67 have been made to a US research group in July demonstrating the ability of Iotron-CIIC to make and supply this critical isotope. Batches of Cu-67 are being produced biweekly for researchers, and by the end of 2021, more will be available to support clinical trials in North America and around the world.

For more information about the CIIC-Iotron collaboration or to order Cu-67 radioisotope please refer to the website at www.copper67.com.

On August 25, 2021 XRad Therapeutics reported that first patient dosed in Phase 1a Clinical Trial of XRD-0394 for metastatic, locally advanced or recurrent solid tumours(Press release, Aptus Clinical, AUG 25, 2021, View Source [SID1234586867])

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Aptus Clinical is providing CRO support for this study

The dosing of the first patient into US based XRad Therapeutics’ Phase 1a study of XRD-0394 in metastatic, locally advanced or recurrent solid tumours, marks a major milestone for XRad and Aptus Clinical. For XRad, XRD-0394 is their first asset to reach clinical development, whilst for Aptus this is the first study utilising their US-based CRA team. As part of Aptus’ full-service delivery capability, the US CRAs, working alongside their UK headquartered clinical operations and data management colleagues, now provide significant geographical extension to Aptus’ current experience delivering early phase oncology, cell & gene therapy and rare disease clinical trials in in the UK and EU.

This Phase 1a trial will evaluate the safety and tolerability of single ascending doses of XRD-0394 in combination with radiation therapy. The trial is being conducted at two world renowned centres of excellence: Memorial Sloan Kettering Cancer Center in New York and the Stanford Cancer Institute in Palo Alto, California. XRD-0394 is a first-in-class, oral, dual kinase inhibitor of both ataxia-telangiectasia mutated and DNA-dependent protein kinase and based on preclinical studies is designed to enhance the effectiveness of radiation therapies. Results from this trial will inform the dosing regimen for the company’s planned Phase 1b study.

Tona Gilmer, PhD, President, Chief Executive Officer and co-founder of XRad said in a statement: "We are delighted to be working with our clinical CRO partners at Aptus who are managing the delivery of this vital first study in our development programme. Successful completion will allow us to rapidly move to the next step in our clinical development"

Jonathan Lewis, co-founder and Chief Commercial Officer at Aptus Clinical commented "We are thrilled that the XRad team entrusted the clinical delivery of their first asset to Aptus. Having worked initially with members of our consulting team, recognition of the strength and depth of experience in our operational delivery organisation has been a great endorsement of our capabilities. We look forward to working alongside the XRad team to demonstrate the full benefits of this important potential addition to the cancer treatment armamentarium"

On August 25, 2021 ProMIS Neurosciences Inc. (TSX: PMN) (the "Company" or "ProMIS"), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, reported that it has closed its previously announced upsized public offering (the "Offering") for gross proceeds of US$20,125,000, including the exercise in full of the 15% Agent’s option (Press release, ProMIS Neurosciences, AUG 25, 2021, View Source [SID1234586883]).

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A total of 125,781,250 units of the Company (the "Units") were issued at US$0.16 per Unit pursuant to the Offering. Each Unit consisted of one common share of the Company (a "Common Share") and one-quarter of one Common Share purchase warrant (each whole purchase warrant, a "Warrant"). Each Warrant entitles the holder thereof to purchase one Common Share (each, a "Warrant Share") at a price of US$0.21 per Warrant Share at any time up to August 25, 2026, subject to an acceleration provision.

Leede Jones Gable Inc. (the "Agent") acted as the agent and sole bookrunner pursuant to an agency agreement with the Company dated August 19, 2021 (the "Agency Agreement"), and Ceros Financial Services, Inc. acted as the exclusive sub-agent for the sale of Units in certain jurisdictions.

In consideration for the services performed by the Agent pursuant to the Agency Agreement, the Company paid the Agent (or as the Agent otherwise directed) a cash commission equal to 7% of the gross proceeds from the Offering and issued to the Agent (or as the Agent otherwise directed) that number of compensation warrants (the "Compensation Warrants") equal to 7% of the Units sold under the Offering. Each Compensation Warrant entitles the holder thereof to purchase one Common Share (each, a "Compensation Warrant Share") at a price of $0.16 per Compensation Warrant Share at any time up to August 25, 2026.

The Offering was made pursuant to the Company’s prospectus supplement dated August 19, 2021 (the "Supplement") to the Company’s short form base shelf prospectus dated June 30, 2021 (the "Base Prospectus"). Additionally, the Offering was conducted by way of private placement in other jurisdictions where the Offering could lawfully be made. Copies of the Base Prospectus, Supplement and Agency Agreement are available under the Company’s profile on SEDAR at www.sedar.com.

The Company intends to use the net proceeds from the Offering to advance its lead Alzheimer’s therapy PMN310 to the filing of an Investigational New Drug (IND) application to enable a first clinical trial; to expand the Company’s portfolio of antibodies and patents; and for general corporate purposes, including, to establish a discovery laboratory in the Boston area, to accelerate and broaden the scope of the Company’s discovery efforts and to add additional scientific, administrative and support staff, all as further set out in the Supplement.

The investors include Mike Gordon of Fenway Sports Group, the Kraft Group, Henry McCance, cofounder of the Cure Alzheimer’s Fund, and Jeremy Sclar of WS Development Group, all of whom invested in the March 2021 financing, as well as new investors David Adelman of Darco Capital, Michael Rubin, Chairman and CEO of Fanatics, and Aspire Capital Fund, an institutional investor based in Chicago.

The securities being referred to in this news release have not been, nor will they be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the U.S. or to, or for the account or benefit of, U.S. persons absent registration or an applicable exemption from the registration requirements. This news release does not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful.

On August 25, 2021 Pierre Fabre reported 2021 Annual Report (Presentation, Pierre Fabre, AUG 25, 2021, View Source [SID1234639493]).

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