On July 8, 2021 Kezar Life Sciences, Inc. (Nasdaq: KZR), a clinical-stage biotechnology company discovering and developing breakthrough treatments for immune-mediated and oncologic disorders, reported its Co-founder and Chief Scientific Officer, Christopher Kirk, will participate in the "Novel Targets for Autoimmune Diseases" panel discussion at William Blair’s Biotech Focus Conference on Thursday, July 15, 2021, at 11:00 a.m. ET (Press release, Kezar Life Sciences, JUL 8, 2021, View Source [SID1234584716]).

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A live webcast of the panel may be accessed at the "Events & Presentations" section of Kezar’s website at View Source Kezar Life Sciences will maintain an archived replay of the webcast on its website for 90 days after the conference.

On July 8, 2021 Rakuten Medical, Inc. (Rakuten Medical) reported that data from a phase I, single-center, open-label study of RM-1929 photoimmunotherapy in Japanese patients with recurrent head and neck squamous cell carcinoma (rHNSCC) was accepted for publication in the International Journal of Clinical Oncology and published on June 24, 2021 (Press release, Rakuten Medical, JUL 8, 2021, View Source [SID1234584732]).

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The manuscript describes the design of a Phase I study, where patients were given a single fixed dose (640 mg/m²) of RM-1929, an anti-EGFR antibody cetuximab conjugated with a light-activatable dye (IRDye700DX), and a fixed light treatment dose (50 J/cm² for superficial illumination; 100 J/cm fiber diffuser length for interstitial illumination) in Japan. The study was designed to evaluate the safety, tumor response (modified RECIST v1.1 by central radiology review), pharmacokinetics, and immunogenicity administered in subjects with rHNSCC.

The data concluded that RM-1929 photoimmunotherapy showed a manageable safety profile in rHNSCC – and showed tumor response in the heavily pre-treated patient population was clinically meaningful and warranted further investigation.

RM-1929 is a first-in-class drug developed on the Illuminox platform based on photoimmunotherapy and received conditional marketing approval in Japan from the Ministry of Health, Labour and Welfare in September 2020.

A paper of full text is available at View Source

*RM-1929 and ASP-1929 are analogous. Extensive physiochemical studies show that they have comparable physical and chemical properties.

On July 8, 2021 F-star Therapeutics, Inc. (NASDAQ: FSTX) ("F-star" or the "Company"), a clinical-stage biopharmaceutical company dedicated to developing next generation bispecific immunotherapies to transform the lives of patients with cancer, reported that it has entered into an exclusive licensing agreement with AstraZeneca plc (NASDAQ: AZN) ("AstraZeneca"), under which AstraZeneca will receive global rights to research, develop and commercialize next generation Stimulator of Interferon Genes (STING) inhibitor compounds (Press release, AstraZeneca, JUL 8, 2021, View Source [SID1234584767]).

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Under the terms of the agreement, AstraZeneca is granted exclusive access to F-star’s novel preclinical STING inhibitors. AstraZeneca will be responsible for all future research, development and commercialization of the STING inhibitor compounds, and F-star will retain rights to all STING agonists, currently in clinical development for patients with cancer.

Neil Brewis, Chief Scientific Officer of F-star, said, "We are excited to announce this agreement with AstraZeneca to develop these promising drug candidates. STING inhibitors offer enormous potential for new treatments, as STING is known to play a role in activating the innate immune system across a range of inflammatory and autoimmune diseases. We are confident that AstraZeneca can maximize the value of these discovery stage compounds to benefit patients."

Maria Belvisi, Senior Vice President and Head of Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D of AstraZeneca, said, "As part of our bold ambition to develop therapeutic options for patients across immune mediated diseases I am delighted to announce this agreement with F-star to explore novel STING inhibitors. We look forward to advancing our discovery efforts in these areas of high unmet medical need."

F-star is eligible to receive upfront and near-term payments of up to $12 million. In addition, F-star will be eligible for development and sales milestone payments of over $300 million, as well as single digit percentage royalty payments. Payments received by F-star are subject to a contingent value rights agreement (CVR 2), under which a percentage will be payable to stockholders of F-star that were previously stockholders of Spring Bank Pharmaceuticals, Inc. ("Spring Bank") prior to the business combination between F-star and Spring Bank.

On July 8, 2021 Nuvo Pharmaceuticals Inc. (TSX:MRV; OTCQX:MRVFF) d/b/a Miravo Healthcare (Miravo or the Company), a Canadian focused healthcare company with global reach and a diversified portfolio of commercial products, reported that it has been invited to present at the Access to Giving Virtual Investor Conference, which is being held virtually on July 13th – 15th, 2021 (Press release, Nuvo Pharmaceuticals, JUL 8, 2021, View Source [SID1234584701]). Jesse Ledger, Miravo’s President & Chief Executive Officer and Mary-Jane Burkett, Miravo’s Vice President & Chief Financial Officer will be presenting at the conference.

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Access to Giving is a conference themed around investor education and advocacy with 50+ companies presenting, a keynote, three distinctive panels and management will be available for 1×1 meetings.

DATE: Thursday, July 15, 2021

TIME: 9:30 a.m. ET

LIVE PRESENTATION /
REPLAY LINK: View Source

To receive additional information, request an invitation or to schedule a 1×1 meeting, please email [email protected]. Investors can register here.

About Access to Giving

Access to Giving is the first-of-its-kind virtual investor conference and will be held July 13th – 15th, 2021. Companies will have the opportunity to tell their story and conduct 1×1 meetings with qualified investors for charity. 100% of monies raised through donations for 1×1 meetings will be given to causes that are focused on financial literacy and financial education.

On July 8, 2021 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported that it will release its second quarter 2021 financial results and operational highlights before open of U.S. markets on Thursday, August 5, 2021 (Press release, Autolus, JUL 8, 2021, View Source [SID1234584717]).

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Management will host a conference call and webcast at 8:30 am EDT/1:30 pm GMT to discuss the company’s financial results and provide a general business update. To listen to the webcast and view the accompanying slide presentation, please go to the events section of Autolus’ website.

The call may also be accessed by dialing (866) 679-5407 for U.S. and Canada callers or (409) 217-8320 for international callers. Please reference conference ID 9757293. After the conference call, a replay will be available for one week. To access the replay, please dial (855) 859-2056 for U.S. and Canada callers or (404) 537-3406 for international callers. Please reference conference ID 9757293.

Additionally, Christian Itin, CEO of Autolus, will participate in a panel discussion titled "Cell Therapies In the Next Decade" to be held on Wednesday, July 14, at 08.55 a.m. EDT at the William Blair Biotech Focus Conference 2021, taking place virtually from July 14-15, 2021. The company will also host virtual one-on-one meetings at the conference. The live panel discussion can be viewed from the investor section of the Autolus website and will be available for a period of 30 days after the conference.