Intelligent Medical Objects and Multiple Myeloma Research Foundation Partner to Enhance Data for Clinical Research

On June 28, 2021 Intelligent Medical Objects (IMO) a healthcare data quality and enablement company and market leader in medical terminology solutions, and the Multiple Myeloma Research Foundation (MMRF), a leading cancer nonprofit organization dedicated to accelerating a cure for multiple myeloma, reported a partnership to further improve the utility of the clinical data from its MMRF CureCloud and CoMMpass clinical trials (Press release, Multiple Myeloma Research Foundation, JUN 28, 2021, View Source [SID1234584424]).

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The partnership will expand data utility of the clinical data generated by the landmark CureCloud and CoMMpass research programs that are used by the MMRF’s partners to drive precision treatments for myeloma patients. The added capabilities provided by IMO’s data normalization services will enhance the utility of the MMRF’s data for use cases such as patient identification for clinical trials, cohort selection for health outcomes research, and the enhanced ability to provide analytic precision to the MMRF’s real-world data sources.

"We are looking forward to partnering with IMO to streamline data analysis," said Steven Labkoff, MD, MMRF’s Chief Data Officer. "As data leaves the electronic health records (EHRs) crucial metadata elements are often lost when EHRs create human-readable records. That metadata (ICD10, LOINC, RxNorm and other codes) is needed for secondary analysis and cohort creation. Without this information, it becomes a lot more complicated to analyze the data donated by our patients for analysis. By utilizing IMO technology, we will be able to re-introduce this data which in turn will help us to generate insights, and more importantly, help our researchers to more easily utilize our data in an effort to find cures."

Through the CureCloud and CoMMpass research programs, the MMRF has generated some of the richest oncology data sets to drive new precision treatments and a cure for each and every myeloma patient. Recognizing an opportunity to gain more impactful insights from that data, MMRF partnered with IMO to leverage its technology, IMO Precision Normalize, a product that standardizes inconsistent diagnosis, procedure, medication, and lab data from diverse systems into common, clinically validated terminology.

"Any organization that’s in the business of collecting and analyzing clinical data needs to maximize the quality of that data, and the quality of that data depends on the ability to easily and quickly normalize it to precise and understandable standards," said Dale Sanders, Chief Strategy Officer, IMO. "We are excited and grateful to partner with the MMRF to improve oncology patient care and treatment, as well as data quality for MMRF’s partners."

Currently, as healthcare data moves out of the EHR and is aggregated for analytics, it can be inconsistent, incomplete, and inaccurate. Decision-making may be compromised, which may put patient safety and outcomes at risk. Used by over 500,000 physicians during point of care documentation, IMO clinical terminology forms the foundation of IMO Precision Normalize, helping IT leaders and data stewards address the challenges that come with managing and leveraging data derived from multiple health information systems and sources.

To learn more about IMO Precision Normalize visit here.

About IMO

Intelligent Medical Objects (IMO) is a healthcare data enablement company. From clinical documentation at the point of care to complex approaches to population health management, IMO ensures clinical data integrity and quality—making patient information fit-for-purpose across the healthcare ecosystem. For almost three decades, IMO’s footprint in EHRs—across more than 4,500 US hospitals—powers our expert ability to capture and preserve clinical intent wherever and however data is used. Our primary clients span individual doctors and physician groups, hospitals and clinics, large integrated delivery networks, inpatient ORs and surgical centers, global electronic health record providers, health information exchanges, clinical data registries, payers, life sciences companies, and healthcare analytics vendors.

IMO is built on a culture that celebrates and practices diversity, equity, and inclusion. Our employees strive every day to make a meaningful impact in healthcare. IMO’s technology platform and evolving portfolio of products are grounded in our industry leading medical terminologies, which are clinically vetted and always current, capturing data at the highest level of specificity. IMO understands how data must then be transformed to efficiently extract the greatest value. In short, IMO is the catalyst that enables accurate documentation, precise population cohorting, optimized reimbursements, robust analytics, and better care decisions to optimize patient outcomes.

Transactions in connection with share buy-back program

On June 28, 2021 Genmab reported the initiation of a share buy-back program to mitigate dilution from warrant exercises and to honor our commitments under our Restricted Stock Units program (Press release, Genmab, JUN 28, 2021, View Source [SID1234584393]).

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The share buy-back program is expected to be completed no later than June 30, 2021 and comprises up to 200,000 shares.

The following transactions were executed under the program from June 21, 2021, to June 25, 2021:

No. of shares

Average price (DKK)

Total value (DKK)

Accumulated through last announcement

Details of each transaction are included as an appendix to this announcement.

Following these transactions, Genmab holds 292,606 shares as treasury shares, corresponding to 0.45% of the total share capital and voting rights.

The share buy-back program is undertaken in accordance with Regulation (EU) No. 596/2014 (‘MAR’) and the Commission Delegated Regulation (EU) 2016/1052, also referred to as the "Safe Harbour Regulation." Further details on the terms of the share buy-back program can be found in our company announcement no. 11 dated February 23, 2021.

Vincerx Pharma Announces Inclusion in Russell 3000® and Microcap® Indexes

On June 28, 2021 Vincerx Pharma, Inc. (Nasdaq: VINC), a biopharmaceutical company aspiring to address the unmet medical needs of patients with cancer through paradigm-shifting therapeutics, reported that the Company has joined the broad-market Russell 3000 and Microcap Indexes as part of the 2021 Russell indexes annual reconstitution, effective after the U.S. market opens today, Monday, June 28, 2021 (Press release, Vincerx Pharma, JUN 28, 2021, View Source [SID1234584409]).

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"Vincerx is pleased to be included in the Russell 3000 and Microcap Indexes, a milestone that highlights our growth since becoming a public company late last year and will broaden our visibility within the investment community," said Ahmed Hamdy M.D., Chief Executive Officer of Vincerx. "Our inclusion in these indexes demonstrates our continued commitment to creating value for our shareholders, and we look forward to continuing our mission of developing innovative targeted oncology therapeutics to transform treatment paradigms for hematological malignancies and solid tumors."

Annual Russell indexes reconstitution captures the 4,000 largest U.S. stocks as of May 7, ranking them by total market capitalization. Membership in the U.S. all-cap Russell 3000 Index, which remains in place for one year, means automatic inclusion in the large-cap Russell 1000 Index or small-cap Russell 2000 Index as well as the appropriate growth and value style indexes. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings and style attributes.

Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $10.6 trillion in assets are benchmarked against Russell’s US indexes. Russell indexes are part of FTSE Russell, a leading global index provider.

For more information on the Russell 3000 Index and the Russell indexes reconstitution, go to the "Russell Reconstitution" section on the FTSE Russell website.

About FTSE Russell:
FTSE Russell is a global index leader that provides innovative benchmarking, analytics and data solutions for investors worldwide. FTSE Russell calculates thousands of indexes that measure and benchmark markets and asset classes in more than 70 countries, covering 98% of the investable market globally.

FTSE Russell index expertise and products are used extensively by institutional and retail investors globally. Approximately $17.9 trillion is currently benchmarked to FTSE Russell indexes. For over 30 years, leading asset owners, asset managers, ETF providers and investment banks have chosen FTSE Russell indexes to benchmark their investment performance and create ETFs, structured products and index-based derivatives.

A core set of universal principles guides FTSE Russell index design and management: a transparent rules-based methodology is informed by independent committees of leading market participants. FTSE Russell is focused on applying the highest industry standards in index design and governance and embraces the IOSCO Principles. FTSE Russell is also focused on index innovation and customer partnerships as it seeks to enhance the breadth, depth and reach of its offering.

FTSE Russell is wholly owned by London Stock Exchange Group.

Nimble Therapeutics and RayzeBio Announce Strategic Research Collaboration to Discover & Develop Novel Peptide-Based Radiopharmaceuticals

On June 28, 2021 Nimble Therapeutics and RayzeBio reported the companies have entered a strategic collaboration to discover and develop novel peptide-based radiopharmaceuticals for treatment of cancer (Press release, Nimble Therapeutics, JUN 28, 2021, View Source [SID1234584425]).

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"We are excited to welcome RayzeBio to our growing family of partners," said Jigar Patel, Ph.D., CEO of Nimble Therapeutics. "Through our pioneering work, we have built a platform to rapidly identify drug-like hits and optimize them into leads, and conduct elaborate medicinal chemistry campaigns to engineer candidates with optimal potency, selectivity, stability, and other important attributes. This agreement with RayzeBio underscores the value inherent in Nimble’s platform to advancing the radiopharmaceutical field."

"Nimble’s platform technology is promising," said Ken Song, M.D., CEO of RayzeBio. "Nimble’s rational approach to using its platform to identify novel peptide-like molecules allows us to further expand our radiopharmaceutical pipeline and pursue multiple therapeutic programs in parallel."

Under the terms of the agreement, Nimble will receive an undisclosed upfront payment, research reimbursements and may also receive further milestone payments and royalties on sales of resulting products. RayzeBio has exclusive rights to develop and commercialize peptides discovered under the collaboration, and an option to further expand the collaboration to include additional targets.

ORIC Pharmaceuticals Announces FDA Clearance of IND Application for ORIC-533, a Highly Potent, Orally Bioavailable Small Molecule CD73 Inhibitor

On June 28, 2021 ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, reported that the U.S. Food and Drug Administration (FDA) has cleared the company’s Investigational New Drug Application (IND) for ORIC-533 to proceed into a first-in-human clinical trial. ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy and immunotherapy-based treatment regimens (Press release, ORIC Pharmaceuticals, JUN 28, 2021, View Source [SID1234584394]).

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The FDA clearance of our IND application for ORIC-533 is a significant milestone for ORIC as we move into the clinic with a second novel, internally discovered oncology drug candidate," said Jacob Chacko, M.D., president and chief executive officer. "In preclinical studies, ORIC-533 has demonstrated higher potency within a high AMP environment compared to all CD73 and adenosine receptor inhibitors against which it was compared. Furthermore, in addition to the potential best-in-class properties of ORIC-533, we are excited about its differentiated clinical development plan that will explore its single agent activity in contrast to the combination studies that dominate the CD73 field today."

Based on a preclinical collaboration with an academic key opinion leader that generated compelling single agent activity in patient derived model systems in an undisclosed tumor type, the company plans to pursue a single agent clinical development plan in this indication. ORIC plans to initiate the Phase 1 clinical trial with ORIC-533 in the second half of 2021 to evaluate safety, PK and preliminary efficacy in cancer patients.

This is the first of three planned IND/CTA filings for 2021, with the IND filing for ORIC-944 and CTA filing for ORIC-114 expected in the second half of the year.

About ORIC-533

ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy and immunotherapy-based treatment regimens. ORIC-533 has demonstrated greater potency in preclinical studies compared to an antibody approach, other small molecule CD73 inhibitors and inhibitors of adenosine receptors. Preclinical data suggest ORIC-533 binds CD73 with high affinity and effectively blocks adenosine-driven immunosuppression in a high AMP environment. In preclinical studies, nanomolar concentrations of ORIC-533 efficiently rescued cytotoxic T-cell function in the presence of high AMP concentrations, reflective of AMP levels observed in tumors.