On August 2, 2021 Reata Pharmaceuticals, Inc. (Nasdaq: RETA) ("Reata" or the "Company"), a clinical-stage biopharmaceutical company, reported that it will report financial results and provide an update on recent progress on its development programs after the market closes on August 9, 2021 (Press release, Reata Pharmaceuticals, AUG 2, 2021, View Source [SID1234585539]).

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Reata’s management will host a conference call on August 9, 2021, at 4:30 pm ET. The conference call will be accessible by dialing (866) 270-1533 (toll-free domestic) or (412) 317-0797 (international) using the access code: 10157197. The webcast link is View Source

Second quarter financial results to be discussed during the call will be included in an earnings press release that will be available on the company’s website shortly before the call at View Source and will be available for 12 months after the call. The audio recording and webcast will be accessible for at least 90 days after the event at View Source.

On August 2, 2021 Jacobio Pharmaceuticals (1167.HK) reported the first patient was dosed in a Phase I/II clinical trial of KRAS G12C inhibitor JAB-21822 in China (Press release, Jacobio Pharmaceuticals, AUG 2, 2021, View Source [SID1234585554]).

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JAB-21822 is Jacobio’s innovative in-house small molecule anti-cancer drug, which is designed to target the KRAS G12C mutation. It will be used to treat advanced solid tumors with KRAS G12C mutation, including but not limited to non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors. The global incidence of the KRAS G12C mutation in patients with NSCLC, ovarian cancer, CRC and pancreatic cancer reached approximately 295,000 in 2019.

JAB-21822 has best-in-class potential among KRAS G12C inhibitors. Internal pre-clinical head-to-head animal studies comparisons have shown JAB-21822 to have a superior pharmacokinetic (PK) profile and favorable tolerability as well as potential for a superior dosing profile in comparison with its competitors.

The Phase I/II trial is a multi-center, open label study of assessing the safety and tolerability of JAB-21822 in patients with advanced solid tumors and the efficacy of JAB-21822 in patients with non-small lung cancer harboring KRAS G12C mutation.

"KRAS is the first oncogene discovered by scientists, it has long been considered ‘undruggable’ for its smooth surface so that it’s hard to bind with small molecule anti cancer drug. We hope that JAB-21822 will benefit more patients with better treatment choice", said Professor Lin Shen of the Beijing Cancer Hospital.

"JAB-21822 is our in-house innovative drug candidate with promising pre-clinical data. We will continue to advance clinical trials with researchers, so that we can bring hope to patients," said Dr. Yinxiang Wang, Chairman and CEO of Jacobio.

The clinical study of JAB-21822 has been initiated after the IND (investigational new drug) approval by the US FDA in May 2021.

On August 2, 2021 Syndax Pharmaceuticals, Inc. ("Syndax," the "Company" or "we") (Nasdaq: SNDX), a clinical stage biopharmaceutical company developing an innovative pipeline of cancer therapies, reported that it will release its second quarter 2021 financial results on Monday, August 9, after the close of the U.S. financial markets (Press release, Syndax, AUG 2, 2021, View Source [SID1234585520]).

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In connection with the earnings release, Syndax’s management team will host a conference call and live audio webcast at 4:30 p.m. ET on Monday, August 9, to discuss the Company’s financial results and provide a general business update.

The live audio webcast and accompanying slides may be accessed through the Events & Presentations page in the Investors section of the Company’s website at www.syndax.com. Alternatively, the conference call may be accessed through the following:

For those unable to participate in the conference call or webcast, a replay will be available on the Investors section of the Company’s website, www.syndax.com.

On August 2, 2021 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported an agreement with Moderna, a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, granting Moderna an exclusive license to develop and commercialize mRNA therapeutics incorporating Autolus’ proprietary binders for up to four immuno-oncology targets (Press release, Autolus, AUG 2, 2021, View Source [SID1234585540]).

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Autolus would be eligible to receive an upfront payment for each target licensed by Moderna and development and commercial milestone payments for each product successfully commercialized. In addition, Autolus would be entitled to receive royalties on net sales of all products commercialized under the agreement.

"We are pleased that Moderna has selected Autolus as a partner for certain mRNA-based therapeutics in oncology indications," said Dr. Martin Pulé, founder and chief scientific officer of Autolus. "The use of our technology in Moderna’s mRNA platform underscores Autolus’ leadership in the development of innovative differentiated binder and cell programming technologies."

On August 2, 2021 Nuvalent, Inc., a biopharmaceutical company focused on creating precisely targeted therapies for clinically proven kinase targets in cancer, reported the closing of its upsized initial public offering of 11,212,500 shares of common stock, consisting of 10,612,500 shares of Class A common stock and 600,000 shares of Class B common stock, which includes 1,462,500 shares of Class A common stock sold pursuant to the exercise in full by the underwriters of their option to purchase additional shares, each at a price to the public of $17.00 per share (Press release, Nuvalent, AUG 2, 2021, View Source [SID1234585555]). The gross proceeds of the offering were approximately $190.6 million, before deducting underwriting discounts and commissions and other offering expenses. The Class A common stock began trading on The Nasdaq Global Select Market under the ticker symbol "NUVL" on July 29, 2021. All shares in the offering were offered by Nuvalent.

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J.P. Morgan, Cowen and Piper Sandler are acting as joint book-running managers for the offering.

A registration statement relating to these securities was declared effective by the Securities and Exchange Commission on July 28, 2021. The offering was made only by means of a written prospectus. Copies of the final prospectus relating to the initial public offering can be obtained, when available, from: J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone (866) 803-9204 or by email at [email protected]; Cowen and Company, LLC c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY, 11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926; and Piper Sandler & Co., 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, Attention: Prospectus Department, by telephone at (800) 747-3924, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.