On June 10, 2021 Vernalis and Servier reported the achievement of one research and one pre-clinical milestone in their oncology drug discovery collaboration, triggering undisclosed milestone payments to Vernalis (Press release, Servier, JUN 10, 2021, View Source;utm_medium=rss&utm_campaign=vernalis-and-servier-achieve-two-milestones-in-their-oncology-drug-discovery-collaboration [SID1234583812]).

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Vernalis and Servier’s partnership has been running successfully since 2007. The collaboration takes advantage of Vernalis’ proprietary fragment and structure-based drug discovery platform, and of Servier’s expertise in medicinal chemistry, cancer biology and pharmacology to bring innovation in oncology one step further.

The collaboration focuses on complicated molecular targets, some of which, like Mcl-1, were considered as undruggable until recently. Previously, has been announced the discovery of the first generation of Mcl-1 inhibitors which have entered clinical trials (published in Nature, 538: 477; ACS Omega, 4: 8892; J Med Chem, 63: 13762). The pre-clinical milestone announced today corresponds to a second generation, selective Mcl-1 inhibitor entering pre-clinical development. The research milestone relates to success in early drug discovery against another challenging, promising but undisclosed target.

These milestones further validate our fragment and structure-based drug discovery platform as well as the strength and success of our relationship with Servier. We look forward to working together to develop exciting new cancer treatment opportunities to add to the already disclosed success in targeting Bcl-2 and Mcl-1", commented James Murray, Research Director at Vernalis.

"These research and clinical milestones are the result of highly interactive joint efforts between chemists, biochemists and biologists from both companies and hopefully will lead to new treatments for cancer patients," Olivier Geneste, Head of Apoptosis and Targeted Therapies Research Program in Oncology at Servier commented. "They illustrate well the innovative freedom that Servier has kept through its important investment in R&D."

Under the current agreement, Vernalis receives fees for work undertaken as well as research and development milestones and potentially royalties on sales.

On June 10, 2021 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) reported that the Company’s share capital has been increased by nominally DKK 804,440 as a consequence of employees’ exercise of warrants (Press release, Bavarian Nordic, JUN 10, 2021, View Source [SID1234583828]).

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The capital increase was effected without any pre-emption rights for the existing shareholders of the Company or others. A total of 80,444 new shares were subscribed for in cash at DKK 205.80 per share of nominally DKK 10. The total proceeds to Bavarian Nordic A/S from the capital increase amounts to DKK 16.6 million.

The new shares, which will rank pari passu in all respects with existing Bavarian Nordic shares, will be admitted to trading and official listing on Nasdaq Copenhagen as soon as possible.

After the capital increase, the total nominal value of Bavarian Nordic A/S’ share capital is DKK 638,172,480, which is made up of 63,817,248 shares of a nominal value of DKK 10 each, corresponding to 63,817,248 votes.

The revised Articles of Association will be published separately and will subsequently be available on the Company’s website.

The content of this announcement does not affect the Company’s expectations for the financial results for 2021.

On June 10, 2021 Theratechnologies Inc. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, reported that it will host a key opinion leader (KOL) webinar on the Company’s SORT1+ Technology and TH1902, its lead investigational peptide-drug conjugate (PDC) for treating sortilin-expressing advanced solid tumors, on Monday, June 21, 2021 at 11:00 a.m. Eastern Time (Press release, Theratechnologies, JUN 10, 2021, View Source [SID1234583813]).

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The webinar will feature a presentation by KOL Richard Béliveau, Ph.D., Université du Québec à Montréal, who will discuss the science of receptor-mediated cancer therapy and the discovery of sortilin as a novel target in cancer treatment. Dr. Béliveau will be available to answer questions following the formal presentations. Theratechnologies’ President and Chief Executive Officer Paul Lévesque and Senior Vice President and Chief Medical Officer Christian Marsolais, Ph.D. will also give an update on its oncology program.

SORT1+ Technology is a new class of cancer treatment targeting all sortilin-expressing cancers by linking approved anticancer drugs to a proprietary peptide that specifically binds to the sortilin receptor. The PDC is internalized by the sortilin receptor and the therapeutic agent is released directly inside the cancer cell.

TH1902 was granted fast track designation by the U.S. Food and Drug Administration (FDA) as a single agent for the treatment of all advanced solid tumors expressing sortilin that are refractory to standard therapy and is currently being evaluated in a Phase 1 clinical trial.

On June 10, 2021 Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, reported its participation in the JMP Securities Life Sciences Conference (Press release, Kura Oncology, JUN 10, 2021, View Source [SID1234583831]). Troy Wilson, Ph.D., J.D., President and Chief Executive Officer, is scheduled to present in a virtual fireside chat at 3:00 p.m. ET / 12:00 p.m. PT on Thursday, June 17, 2021.

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A live audio webcast of the presentation will be available in the Investors section of Kura’s website at www.kuraoncology.com, with a replay available shortly after the live event.

On June 10, 2021 Precigen, Inc. (Nasdaq: PGEN), a biopharmaceutical company specializing in the development of innovative gene and cell therapies to improve the lives of patients, reported Helen Sabzevari, PhD, President and CEO of Precigen, will participate in a fireside chat at the annual JMP Securities Life Sciences Conference on Thursday, June 17, 2021 at 11:00 AM ET (Press release, Precigen, JUN 10, 2021, View Source [SID1234583851]).

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Participants may access the live webcasts of the virtual events through Precigen’s website in the Events & Presentations section at investors.precigen.com/events-presentations.