On June 10, 2021 HOOKIPA Pharma Inc. (NASDAQ: HOOK, ‘HOOKIPA’), a company developing a new class of immunotherapeutics based on its proprietary arenavirus platform, reported that HOOKIPA’s management team will participate and present at the following upcoming virtual investor conferences (Press release, Hookipa Biotech, JUN 10, 2021, View Source [SID1234583827]):

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

SVB Leerink CybeRx Series: Vaccine Forum, June 21 – 22, 2021

JMP Securities Life Sciences Conference, June 16 – 17, 2021
Fireside Chat: June 17, 10:00am ET
The live audio webcast of the fireside chat will be available within the Investors & Media section of HOOKIPA’s website at View Source An archived replay will be accessible for 30 days following the event.

On June 10, 2021 Labcorp (NYSE: LH), a leading global life sciences company, and OmniSeq, a CAP-accredited, molecular diagnostic innovation of Roswell Park Comprehensive Cancer Center, reported the launch of OmniSeq INSIGHTsm, a comprehensive genomic and immune profiling, tissue-based test that integrates next-generation sequencing (NGS) technology (Press release, OmniSeq, JUN 10, 2021, View Source [SID1234583930]). The test is designed to advance precision oncology and improve patient outcomes, as part of Labcorp’s commitment to empower better health decisions for patients through the addition of cutting-edge diagnostic tools in precision medicine.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"There continue to be significant advancements in the oncology space, including the identification of new biomarkers and therapies at an unprecedented pace," said Prasanth Reddy, M.D., MPH, senior vice president and oncology head at Labcorp and a triple board-certified oncologist. "This new test provides up-to-date, evidence-based treatment recommendations and incorporates current guidelines into a report that is easy to interpret, allowing clinicians to make the best treatment choices for their patients, including potential clinical trials."

OmniSeq INSIGHT is a pan-cancer, solid tumor test that combines two different treatment paradigms— genomic and immune profiling, including tumor mutational burden, microsatellite instability, and immune gene expression, which enhances the characterization of the unique genomic biomarkers in a patient’s tumor. The results from the test are presented in an easy-to-read report, summarizing all FDA-approved therapies and immunotherapies that match the patient’s tumor profile. This enables clinicians to provide the most up-to-date treatments for their patients, in addition to identifying clinical trials for which patients may be eligible within 200 miles of their homes. The report provides evidence-based recommendations specific to the individual test results through the use of a proprietary database sourced from numerous biologic and scientific literature, including National Comprehensive Cancer Network (NCCN) guidelines, giving clinicians access to the most advanced treatment options.

OmniSeq INSIGHT is available to U.S.-based clinicians exclusively through Labcorp, and across Canada through Dynacare, a Labcorp company. The test is also available to global biopharmaceutical companies exclusively through Labcorp Drug Development. This can help reduce development time and costs while maximizing patient stratification by accelerating biomarker selection in preclinical and clinical development, and in targeted therapeutic and companion diagnostic development.

Labcorp Drug Development has a proven track record of providing a range of solutions and can offer the scalability required, backed by global expertise, regulatory guidance and informatics systems that are tailored to the biopharmaceutical partner’s unique development needs.

"We are excited to advance our partnership with Labcorp, continuing to provide increased access to oncology care for patients leveraging Labcorp’s extensive footprint and oncology experience," said Margot Schoenborn, CEO of OmniSeq. "We are making this test available globally to biopharmaceutical customers for incorporation into their clinical trials for biomarker stratification, and to support new precision medicine oncology approaches to drug and companion diagnostic development."

OmniSeq INSIGHT is NYS CLEP approved and leverages Labcorp’s broad national coverage, including in-network with most major health plans and 1,600 contractual relationships with plans, payers and other health care organizations.

On June 10, 2021 ALX Oncology (NASDAQ:ALXO), a clinical-stage immuno-oncology company developing therapies that block the CD47 checkpoint pathway, reported it has entered into a clinical trial collaboration and supply agreement with Eli Lilly and Company to evaluate the combination of ALX148, a next generation CD47 blocker, and CYRAMZA (ramucirumab), Lilly’s anti-VEGFR2 antibody, for the treatment of patients with HER2-positive gastric cancer or gastroesophageal junction cancer (Press release, ALX Oncology, JUN 10, 2021, View Source [SID1234605500]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Under the terms of the agreement, ALX Oncology will conduct a randomized Phase 2/3 study to evaluate the efficacy of ALX148 in combination with ramucirumab, trastuzumab, and paclitaxel for the treatment of patients whose tumors have progressed following treatment with HER2-targeted therapy and chemotherapy. Lilly will supply ramucirumab for this trial. Financial details of the collaboration agreement are undisclosed.

This clinical collaboration is based on compelling data from the ongoing ASPEN-01 Phase 1b trial in patients with HER2-positive gastric or gastroesophageal junction cancer who had progressed on one or more lines of trastuzumab therapy, which was presented at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s 35th Anniversary Annual Meeting in November 2020. ALX148 demonstrated a promising initial objective response rate of 64 percent with the combination with ramucirumab, trastuzumab and paclitaxel in patients who historically have low response rates and poor outcomes in this clinical setting. Updated data from the ASPEN-01 Phase 1b trial will be presented at the ESMO (Free ESMO Whitepaper) 23rd World Congress on Gastrointestinal Cancer on July 3, 2021.

"We are thrilled to enter this collaboration with Lilly that aims to provide a CD47-targeted combination regimen for gastric or gastroesophageal junction cancer patients in need of novel effective treatment options," said Jaume Pons, Ph.D., Founder, President and Chief Executive Officer of ALX Oncology. "Our team has worked tirelessly to advance the clinical development of ALX148 in the fight against cancer, and we believe that ALX148 has the potential to be best-in-class as a new foundational immunotherapy in both hematologic and solid tumors."

ALX Oncology owns worldwide commercial rights to ALX148.

About Gastric Cancer
Gastric cancer begins in the cells lining the inner wall of the stomach and spreads through the outer layers and eventually the body as it grows. It is estimated that there will be over 26,000 newly diagnosed cases of gastric cancer at all stages in the U.S. in 2021, and approximately 17 percent of all gastric cancer patients have HER2-positive disease. The five-year survival rate is only 5.5 percent for those patients diagnosed with metastatic disease. Gastric cancer is much more common in East Asian countries, with incidence rates 4 to 10 times higher than in the U.S.

On June 10, 2021 Vernalis and Servier reported the achievement of one research and one pre-clinical milestone in their oncology drug discovery collaboration, triggering undisclosed milestone payments to Vernalis (Press release, Servier, JUN 10, 2021, View Source;utm_medium=rss&utm_campaign=vernalis-and-servier-achieve-two-milestones-in-their-oncology-drug-discovery-collaboration [SID1234583812]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Vernalis and Servier’s partnership has been running successfully since 2007. The collaboration takes advantage of Vernalis’ proprietary fragment and structure-based drug discovery platform, and of Servier’s expertise in medicinal chemistry, cancer biology and pharmacology to bring innovation in oncology one step further.

The collaboration focuses on complicated molecular targets, some of which, like Mcl-1, were considered as undruggable until recently. Previously, has been announced the discovery of the first generation of Mcl-1 inhibitors which have entered clinical trials (published in Nature, 538: 477; ACS Omega, 4: 8892; J Med Chem, 63: 13762). The pre-clinical milestone announced today corresponds to a second generation, selective Mcl-1 inhibitor entering pre-clinical development. The research milestone relates to success in early drug discovery against another challenging, promising but undisclosed target.

These milestones further validate our fragment and structure-based drug discovery platform as well as the strength and success of our relationship with Servier. We look forward to working together to develop exciting new cancer treatment opportunities to add to the already disclosed success in targeting Bcl-2 and Mcl-1", commented James Murray, Research Director at Vernalis.

"These research and clinical milestones are the result of highly interactive joint efforts between chemists, biochemists and biologists from both companies and hopefully will lead to new treatments for cancer patients," Olivier Geneste, Head of Apoptosis and Targeted Therapies Research Program in Oncology at Servier commented. "They illustrate well the innovative freedom that Servier has kept through its important investment in R&D."

Under the current agreement, Vernalis receives fees for work undertaken as well as research and development milestones and potentially royalties on sales.

On June 10, 2021 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) reported that the Company’s share capital has been increased by nominally DKK 804,440 as a consequence of employees’ exercise of warrants (Press release, Bavarian Nordic, JUN 10, 2021, View Source [SID1234583828]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The capital increase was effected without any pre-emption rights for the existing shareholders of the Company or others. A total of 80,444 new shares were subscribed for in cash at DKK 205.80 per share of nominally DKK 10. The total proceeds to Bavarian Nordic A/S from the capital increase amounts to DKK 16.6 million.

The new shares, which will rank pari passu in all respects with existing Bavarian Nordic shares, will be admitted to trading and official listing on Nasdaq Copenhagen as soon as possible.

After the capital increase, the total nominal value of Bavarian Nordic A/S’ share capital is DKK 638,172,480, which is made up of 63,817,248 shares of a nominal value of DKK 10 each, corresponding to 63,817,248 votes.

The revised Articles of Association will be published separately and will subsequently be available on the Company’s website.

The content of this announcement does not affect the Company’s expectations for the financial results for 2021.