BriaCell Therapeutics to Present at the American Association for Cancer Research Annual Meeting 2021

On March 30, 2021 BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW) (TSX-V:BCT) ("BriaCell" or the "Company"), a clinical-stage biotechnology company specializing in targeted immunotherapies for advanced breast cancer, reported that it has been selected to present at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021, a virtual meeting, held over two weeks (Week 1: April 10-15; Week 2: May 17-21) (Press release, BriaCell Therapeutics, MAR 30, 2021, View Source [SID1234577404]).

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BriaCell will be presenting the results of its analysis of clinical and pathological data of its lead candidate, Bria-IMT, a novel immunotherapy for advanced breast cancer, as monotherapy and a Phase I/IIa clinical study of Bria-IMT in combination with immune checkpoint inhibitors, including pembrolizumab (KEYTRUDA; manufactured by Merck & Co., Inc.) and, more recently, Incyte’s INCMGA00012 (under a corporate collaboration with Incyte Corporation). The patient data belong to previously-disclosed patients (i.e., no incremental numbers enrolled).

Details include:

Abstract Control Number: 4932
Title: Predictors of response to a modified whole tumor cell immunotherapy in patients with advanced breast cancer from two phase I/IIa trials
Session Type: E-Poster Session
Session Category: Phase I Clinical Trials
Session Title: Phase I Clinical Trials
Permanent Abstract Number: CT102
Session Date and Time: Saturday, April 10 at 8:30 a.m. ET. E-posters will remain available for viewing through Monday, June 21.

Following the presentation, a copy of the poster will be posted on View Source

Additionally, the Board of Directors of the Company (the "Board") unanimously approved the grant of an aggregate of 617,300 incentive stock options ("Stock Options") to directors, officers, employees and consultants under the Company’s stock option plan ("Stock Option Grant"). Of the Stock Option Grant, 560,000 Stock Options will be granted to Insiders, as such term is defined in the Securities Act (British Columbia). The Stock Options are exercisable at US$4.24 per common share in the capital of the Company ("Common Share"), will vest immediately, and will expire in 5 years from the date of issuance. Following the Stock Option Grant, the Company has 635,352 Stock Options outstanding.

The Stock Option Grant to certain Insiders constitutes a "related party transaction" within the meaning of Exchange Policy 5.9, which incorporates Multilateral Instrument 61-101 ("MI 61-101"). The Company is exempt from shareholder approval in accordance with section 5.7.1(a) of MI 61-101. The Stock Option Grant will not result in a new Control Person.

ONCOTELIC THERAPEUTICS, INC. (FORMERLY MATEON THERAPEUTICS, INC.) NAME AND SYMBOL CHANGE.

On March 30, 2021 Oncotelic Therapeutics, Inc. ("Oncotelic" or the "Company") (OTCQB:OTLC) (f/k/a Mateon Therapeutics, Inc.) reported that the Financial Industry Regulatory Authority ("FINRA") has confirmed the change in the Company’s name and approved the stock symbol trading on the OTC Markets (Press release, Mateon Therapeutics, MAR 30, 2021, View Source [SID1234577347]). Effective today, March 30, 2021, the ticker symbol is changed from "MATN" to "OTLC".

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On August 14, 2020, the Company filed a Current Report on Form 8-K, in which the Company reported a number of corporate actions approved by the shareholders of the Company on August 10, 2020, including the name change and symbol change. The Company formally changed its name to Oncotelic Therapeutics, Inc. with the State of Delaware in November 2020, as disclosed in its Quarterly Report on Form 10-Q for the quarter ended September 30, 2020, filed with the Securities and Exchange Commission on November 16, 2020. A notice of corporate action was filed with FINRA, requesting confirmation of its name change and approval for the new ticker symbol. On March 29, 2021, the Company received FINRA’s approval on its notice of corporate action confirming the new company name and the change in the Company’s ticker symbol, effective March 30, 2021.

Cardinal Health to Webcast Discussion of Third-Quarter Results for Fiscal Year 2021 on May 6

On March 30, 2021 Cardinal Health (NYSE: CAH) reported third-quarter financial results for its fiscal year 2021 on May 6 prior to the opening of trading on the New York Stock Exchange (Press release, Cardinal Health, MAR 30, 2021, View Source [SID1234577363]). The company will webcast a discussion of these results beginning at 8:30 a.m. Eastern.

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To access the webcast and corresponding slide presentation, go to the Investor Relations page at ir.cardinalhealth.com. No access code is required. Presentation slides and a webcast replay will be available until May 5, 2022.

BostonGene Announces Acceptance of Eight Abstracts to be Presented at the American Association for Cancer Research (AACR) Annual Meeting 2021

On March 30, 2021 BostonGene Corporation, a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, reported that eight abstracts were selected for poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021, which will be conducted virtually from April 10 – 15, 2021 and May 17 – 21, 2021 (Press release, BostonGene, MAR 30, 2021, View Source [SID1234577379]).

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The presentations underscore the importance of the application of novel and cutting-edge analytical tools to improve the diagnosis and treatment for cancer patients. These tools were applied across a wide range of cancers to further understand tumor biology and identify biomarkers for diverse therapies in an effort to propel precision medicine to the forefront of clinical decision making.

"We are proud to present at the AACR (Free AACR Whitepaper) Annual Meeting. These results demonstrate BostonGene’s unique ability to identify novel and personalized treatment options through next generation multi-platform analytics, further advancing and optimizing outcomes for each cancer patient," said Nathan Fowler, MD, Chief Medical Officer at BostonGene.

Details of the poster presentations are below:

Title: AI-driven multifaceted predictive biomarkers of response to tyrosine kinase inhibition and immune checkpoint blockade in clear cell renal cell carcinoma
Session: PO.CL06.06 – Immune Response to Therapies
Poster: 516
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: Association of circulating myeloid derived suppressor cells with systemic lymphopenia following chemoradiotherapy in glioblastoma
Session: PO.CL06.04 – Immune Mechanisms Invoked by Therapies
Poster: 507
Presenter: Dinesh Thotala, PhD, Washington University School of Medicine in St Louis

Research conducted with Washington University School of Medicine in St Louis.

Title: Astraea: A first-in-class biomarker database integrating genomic, transcriptomic, and tumor microenvironment properties for precision oncology
Session: PO.BSB01.03 – Database Resources
Poster: 205
Presenter: Azamat Gafurov, MSc, BostonGene

Title: Evaluating the clinical utility of RNA-seq-based PD-L1 expression and cellular deconvolution as alternatives to conventional immunohistochemistry in clear cell renal cell carcinoma
Session: PO.BSB01.02 – Application of Bioinformatics to Cancer Biology
Poster: 161
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: Integrated multiregional transcriptomic and multi-parameter single-cell imaging analysis of clear cell renal cell carcinoma elucidates diverse cellular communities present within the tumor microenvironment
Session: PO.TB06.04 – Immune Cells in the Tumor Microenvironment
Poster: 2742
Presenter: Natalia Miheecheva, MSc, BostonGene

Research conducted with Washington University School of Medicine in St Louis.

Title: MutAnt: Mutation annotation machine learning algorithm for pathogenicity evaluation of single nonsynonymous nucleotide substitutions in cancer cells
Session: PO.BSB02.01 – Artificial Intelligence and Machine Learning
Poster: 192
Presenter: Aleksandr Sarachakov, MSc, BostonGene

Title: Predictors of treatment responses in a preoperative window of opportunity trial of nivolumab in resectable squamous cell carcinoma of the head and neck
Session: PO.ET02.03 – Role of the Microenvironment in Therapeutic Response
Poster: 1441
Presenter: Nikita Kotlov, MSc, BostonGene

Research conducted with Thomas Jefferson University.

Title: Tumor immune microenvironment based molecular functional clustering reveals a prognostic signature that predicts overall survival in patients with gastric cancer
Session: PO.TB06.08 – Tumor Immune System Interactions
Poster: 3182
Presenter: Prashant V. Thakkar, Weill Cornell Medicine

Research conducted with Weill Cornell Medicine.

The e-poster website will be launched Saturday, April 10, 2021, the first day of the AACR (Free AACR Whitepaper) Virtual Annual Meeting. All e-posters will be made available for browsing on the AACR (Free AACR Whitepaper) Annual Meeting website on this date.

Additionally, the abstracts will be published in an online-only Proceedings supplement to the AACR (Free AACR Whitepaper) journal Cancer Research after the completion of the AACR (Free AACR Whitepaper) Virtual Annual Meeting.

Breakthrough year in the development of Selvita – strategic acquisition & strong financial results

On March 30, 2021 Selvita (WSE: SLV), one of the largest preclinical contract research organizations in Europe, reported today EUR 31.8 million of consolidated revenues which constitutes a 35% increase compared to the values reported a year ago (Press release, Selvita, MAR 30, 2021, View Source;utm_medium=rss&utm_campaign=breakthrough-year-in-the-development-of-selvita-strategic-acquisition-strong-financial-results [SID1234577320]). The Company’s EBITDA result and net profit in 2020 amounted to, respectively, EUR 7.4 million and EUR 4.5 million, comparing to EUR 5.8 million and EUR 3.3 million for a corresponding period last year. The acquisition of Croatian contract research organization Fidelta from Galapagos which took place at the turn of 2020/2021 strengthens Selvita’s position as one of the largest preclinical contract research organizations in Europe.

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Strong financial results

Commercial revenues in the Services Segment increased in 2020 to EUR 25.5 million, showing a 35% increase, compared to EUR 19.6 million in the last year. The EBITDA result of the Services Segment amounted to EUR 6.3 million, which indicates a 23% profitability.

Selvita’s Bioinformatics segment – Ardigen S.A. – reported dynamic development as shown by a 69% y/y increase in commercial revenues up to EUR 4.0 million. The Company’s EBITDA result in 2020 amounted to EUR 1.1 million, an increase of 128% y/y, indicating a 23.6% margin.

In 2020 Selvita focused on expanding its international sales. Revenues from the services originated from the most significant market i.e. commissioned by the customers from the United States, increased by 133% y/y and already constitute nearly 30% of the entire Services Segment revenues. Simultaneously, revenues from the services commissioned by customers from the United Kingdom increased by 42% y/y. Increasing customer recognition related to the high quality of services offered and competent scientists, strengthens Selvita’s position on the largest global biotechnology markets and results in further contracts.

Year 2020 was the first full year where Selvita operated as an independent, purely Contract Research Organization, following the corporate split in October 2019, which was crucial for the Company’s further development. We maintained a high growth rate and achieved very good financial results. In spring, we announced a new development strategy and raised the capital from investors, thanks to which we continue our dynamic organic growth, as well as we initiated the development through acquisitions. The most significant event in our nearly 14-year history occurred at the turn of the year when Selvita acquired Fidelta, a Croatian CRO. This acquisition was a true milestone for our business scale and services portfolio. Our current achievements only motivate us to work further, we are not slowing down and we are looking into the future with optimism – comments Boguslaw Sieczkowski, Chief Executive Officer at Selvita.

Thanks to the teamwork, we consistently strengthen our position among customers. Our employees’ dedication and responsible attitude, allowed us to achieve such good results despite all turbulences caused by the COVID-19 pandemic. Every single person working at Selvita has a significant impact on the Company’s successes – adds Boguslaw Sieczkowski.

Towards further development

In 2020 Selvita consequently realized its strategic goals set up after the corporate split. In the first half of the year, the Company announced a new development strategy for 2020-2023 which assumed further organic growth supported with acquisitions. Selvita successfully raised EUR 20 million from the issue of C series shares and consistently increased its scale of business, hiring world-class specialists, expanding its services portfolio, and investing in technology and state-of-the-art equipment.

One of the key elements of the development strategy is securing own research space, through building Selvita Research Center, that will provide 4000 m2 of own research space necessary for further growth. The Company has already made the first step towards executing this goal and in August 2020 it has signed a contract to purchase a plot of land in the neighborhood of its current laboratories, as well as raised the funding for the investment which includes a EUR 9.3 million grant and a bank loan.

A breakthrough milestone in Selvita’s history – international acquisition

In the fourth quarter of 2020, Selvita announced the acquisition of a Croatian CRO company Fidelta. The transaction valued at EUR 31.2 million was finalized in January 2021. The scope of services provided by Fidelta will extend Selvita’s offer in the area of pharmacology in vivo and toxicology, as well as will increase its scale of operations within DMPK, medicinal chemistry, and in vitro pharmacology. Fidelta brings in also expertise in areas such as infectious diseases, inflammation, and fibrosis. As a result of the acquisition, Selvita gained over 150 highly experienced scientists with a track record of providing integrated drug discovery services to the largest global biotech and pharmaceutical companies, over many years. This historic step in Selvita’s development results in a significant expansion of its scope of services as well as revenue growth.

Last year had a strategic meaning in Selvita’s development, which managed to almost double in business scale thanks to organic growth and the acquisition. Simultaneously, Selvita’s stock price increased by 110%. The increase in Company’s valuation was also continued in Q1 2021. As a result of strengthening its position on the capital market, Selvita was promoted to the mWIG40 index, which gathers 40 leading mid-cap companies listed on the Warsaw Stock Exchange.

Moreover, in recognition of the Company’s performance, Selvita was named the Stock Company of the Year in the competition organized by "Puls Biznesu" – one of the largest business daily in Poland. Selvita also won in two other categories: "The Board Competencies" and "Development Perspectives."

* All % were calculated as compared to results denominated in Polish zloty