On July 20, 2021 Invitae Corporation (NYSE: NVTA), a leading medical genetics company, reported that it will report its second quarter 2021 financial results on Tuesday, August 3, 2021 and will host a conference call and webcast that day at 4:30 p.m. Eastern / 1:30 p.m. Pacific to discuss its financial results and recent highlights (Press release, Invitae, JUL 20, 2021, View Source [SID1234584972]).

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Invitae’s (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. www.invitae.com (PRNewsFoto/Invitae Corporation)

To access the conference call and webcast, please register at the link below:
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Upon registering, each participant will be provided with call details and a registrant ID. Reminders will also be sent to registered participants via email.

The live webcast of the call and slide deck, may be accessed here or by visiting the investors section of the company’s website at ir.invitae.com. A replay of the webcast and conference call will be available shortly after the conclusion of the call and will be archived on the company’s website.

Following prepared remarks, management will respond to questions from analysts, subject to time limitations. We encourage our shareholders and those representing them to send in questions to [email protected].

On July 20, 2021 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported that it will report its 2021 second quarter financial results on Tuesday, August 3, 2021 after the close of the financial markets (Press release, Jazz Pharmaceuticals, JUL 20, 2021, View Source [SID1234584990]). Company management will host a live audio webcast at 4:30 p.m. ET/9:30 p.m. IST to discuss second quarter 2021 financial results and provide a business and financial update.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Interested parties may access the live audio webcast via the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com.

On July 20, 2021 Enochian BioSciences, Inc., a company focused on gene-modified cellular and immune therapies in infectious diseases and cancer, reported that Honorable Mark Dybul, M.D. has been named as Chief Executive Officer (CEO) (Press release, Enochian BioSciences, JUL 20, 2021, View Source [SID1234585128]).

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Dr. Dybul, who has served as Executive Vice-Chair of the Board of Enochian BioSciences since January 2019, is a globally recognized leader in pandemics. He was a principal architect and ultimately the head of the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), the largest international health initiative in history dedicated to a single disease, that achieved historic prevention, care and treatment goals on time and on budget. During his tenure, the program grew from approximately $500 million to $6.5 billion annually. Dr. Dybul went on to transform the Global Fund to Fight AIDS, Tuberculosis and Malaria and, during Dr. Dybul’s four-year tenure, both President Barack Obama and Prime Minister Justin Trudeau hosted funding rounds that raised $25 billion for the Global Fund.

Dr. Dybul has been deeply involved in the fight against COVID-19. He was the only American appointed to the 15-member Independent Panel for Pandemic Preparedness and Response, mandated by the World Health Assembly and co-chaired by former Liberian President Ellen Johnson Sirleaf and former New Zealand Prime Minister Helen Clark. Dr. Dybul also was a member of the High Level Scientific Advisory Group for the G20’s Global Health Summit focused on COVID-19.

Under the mentorship of Dr. Anthony Fauci, Dr. Dybul began his career in public health as a researcher at the National Institute of Allergy and Infectious Diseases, ultimately leading a section of Dr. Fauci’s lab and serving as the Assistant Director for Medical Affairs.

"It is a great privilege to have one of the world’s preeminent public health experts assume the role of CEO of Enochian BioSciences," said Enochian BioSciences’ Chair of the Board René Sindlev. "Mark’s deep expertise in science, combined with his long experience managing research programs and advising on strategy, brings key and difficult-to-find competencies to Enochian BioSciences. Under Mark’s leadership, we are excited to see the organization rapidly advance toward its goal of developing cures for HBV, HIV and potentially, to address inhaled pan-coronavirus and pan-influenza treatment and prevention."

Gregg Alton, Enochian BioSciences’ Board Director, and former interim CEO and longtime General Counsel of Gilead Sciences, said, "I have known Mark since he worked closely with Tony Fauci. I watched him lead what was effectively a start-up in the U.S. Government, PEPFAR, and make it one of the most successful public health programs in history. Mark then went on to transform the Global Fund, a public-private partnership, introducing business models for purchasing, supply chain, and many others. He knows how to lead, develop strategy, maintain the teams’ focus and achieve success."

"As a long-time researcher, clinician, and leader of large global diseases programs, I am very honored to transition from my current role of Executive Vice-Chair to full-time CEO of Enochian BioSciences," said Dr. Dybul. "Based in elegantly brilliant science, we have made significant progress in the past 18 months building a deep and wide pipeline with platforms that address major killers including cancer and infectious diseases. The recent acceleration of potential cures for Hepatitis B, HIV and potential inhaled pan-coronavirus, including the cause of COVID-19, and pan-influenza treatment and prevention — makes it an extremely exciting time to become the CEO of Enochian BioSciences."

On July 20, 2021 Samsung Biologics (KRX: 207940.KS), one of the world’s leading contract development and manufacturing organization (CDMO), reported that signed a strategic partnership agreement with Kineta, Inc., a clinical-stage biotech company developing novel immunotherapies in oncology (Press release, Kineta, JUL 20, 2021, View Source;utm_medium=rss&utm_campaign=kineta-and-samsung-biologics-announce-development-and-manufacturing-agreement-for-anti-vista-antibody-immunotherapy [SID1234584973]). Samsung Biologics will provide end-to-end CDMO service from cell line development, clinical drug substance, and drug product manufacturing services to support IND filing for KVA12.1, Kineta’s novel anti-VISTA antibody in development for the treatment of solid tumors.

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VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate anti-tumor immune function. Preclinical studies demonstrate single agent anti-tumor activity with KVA12.1, and also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the anti-tumor efficacy of those checkpoint inhibitors. Kineta’s KVA12.1 aims to reprogram the TME in hard-to-treat solid tumors.

The manufacturing cell line will be developed with support from Samsung Biologics’ R&D Center in San Francisco, and its corresponding clinical trial materials will be manufactured at Samsung Biologics headquarters in Incheon, South Korea.

"We are very glad to be partnering with Kineta, to provide support in bringing this cancer immunotherapy to market," said John Rim, CEO of Samsung Biologics. "We will fully utilize our capabilities and streamlined end-to-end processes from both our headquarters and US R&D Center, to enable high-quality development of KVA12.1 with faster speed to accelerate Kineta’s success."

"Establishing this strategic partnership with Samsung is a critical step for Kineta as we advance KVA12.1 to IND and into first-in-human clinical trials next year", said Shawn Iadonato, PhD, Chief Executive Officer at Kineta. "We are excited to collaborate with Samsung to initiate and scale up drug product manufacturing of our VISTA immunotherapy".

Samsung Biologics offers seamless one-stop CDMO research and development services both at its headquarters in Incheon, South Korea and its newly built R&D Center in San Francisco. Bringing quality-driven development services at a greater speed, the company delivers cell line development to drug substance manufacturing in six months, and to drug product manufacturing in seven months, the fastest pace in the industry. Currently building its fourth and largest facility in Incheon, Korea, Samsung Biologics will have 620,000 liters of biomanufacturing capacity upon completion of the plant in 2023.

On July 20, 2021 GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, and Insilico Medicine, an industry leader in end-to-end artificial intelligence for target discovery, small molecule chemistry, and clinical development, reported to reach strategic partnership in advancing development of novel therapie (Press release, GenFleet Therapeutics, JUL 20, 2021, View Source [SID1234584991]).

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The agreement outlines a constructive framework where GenFleet will synergize its own R&D systems with Insilico’s end-to-end AI-powered drug discovery platform, with a view to jointly addressing significant unmet medical needs and tackling novel & difficult targets in cancer therapeutics.

In collaboration with Insilico’s AI-powered identification methods, GenFleet will enhance the exploration of the dynamic structure-activity relationship between target proteins and drug molecules through virtual structure research to develop highly selective inhibitors and deliver targeted therapies overcoming drug resistance.

Featuring a competitive pipeline with novel mechanisms, GenFleet has established its comprehensive R&D functions spanning from early discovery to global multi-regional clinical trials. In pursuing targets & indications without proof of concept global-wise, GenFleet has applied latest computational sciences to drug development including DNA-encoded Library screening, computer-aided drug design, digital clinical trial solutions, etc.

Insilico Medicine is a global leader AI-powered drug discovery company. Since 2014, Insilico Medicine developed the AI-powered drug discovery platform consisting of PandaOmics AI-powered novel target discovery engine, Chemistry42 deep generative reinforcement learning system allowing for de-novo design of novel molecules with the desired properties that do not exist in the known chemical space, and InClinico, which predicts clinical trial outcome. As a pioneer and leader in the industry, Insilico Medicine has built a strong drug discovery and development team, a broad distributed discovery partner network, and initiated multiple internal therapeutic programs.

"GenFleet’s portfolio strategy is heavily based on solid technical capabilities, and since its inception, GenFleet has been leveraging such top-notch capabilities world-wide. Through the integration of conventional biotech approaches with emerging technologies such as AI and computational biology, we expect that our R&D capability and efficacy will get a tremendous boost through optimization of target screening, molecular design, real world clinical research, among others. We are very excited to form a collaboration with such leading companies as Insilico, and we look forward to some ‘game-changers’ out of it," said Qiang Lu, Ph.D., Co-founder and Chairman of Board of GenFleet Therapeutics.

"Through cooperation, GenFleet will reinforce its R&D systems with the AI-powered platform and we are projected to substantially improve the success rate of designing original preclinical candidate compounds in shortened cycle time. GenFleet will continuously employ new tools and techniques to enrich its cutting-edge pipeline and develop life-saving medicines for patients around the globe," said Jiong Lan, Ph.D., Co-founder and Chief Executive Officer of GenFleet Therapeutics.

"At Insilico we only partner with the companies that have the commitment to innovate using the latest advances in next-generation AI. We are very excited to collaborate with GenFleet, one of the most innovative biotechnology companies in China now working on unleashing the power of world-class artificial intelligence systems to discover and develop cutting-edge therapeutics for the benefits of the patients worldwide," said Alex Zhavoronkov, PhD, founder and CEO, Insilico Medicine.

"Embracing cooperation and innovation, Insilico is honored to form partnership with GenFleet who shares with us the commitment to innovative drug development. By analyzing and screening huge volumes of data, Insilico’s AI-powered platform boasts unique generation model management and reinforcement learning techniques. We believe our collaboration will provide GenFleet with powerful assistance in its development of transformative therapies," said Feng Ren, Ph.D., Chief Scientific Officer of Insilico Medicine.