On April 15, 2021Transcenta Holding Limited (Transcenta), a clinical stage global biotherapeutics company with fully-integrated capabilities in discovery, development and manufacturing of antibody-based therapeutics, reported that preclinical data of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein, in a poster during the 2021 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting, being held from April 10th to 15th and May 17th to 21st (Press release, Transcenta, APR 15, 2021, View Source [SID1234578100]).

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Title:
The preclinical characterization of TST005, a bi-functional anti-PD-L1 and TGF-β trap fusion protein

Abstract Number: 972
Poster Number: 917

Session Category:
Antibody Technologies

Session Title:
Experimental and Molecular Therapeutics

Poster launch time:
April 10th, 2021, 8:30 a.m.ET, U.S. time

About TST005
TST005, is a bi-functional anti-PD-L1 and TGF-β trap fusion protein designed to simultaneously target two immuno-suppressive pathways, transforming growth factor β-(TGF-β) and programmed cell death ligand-1 (PD-L1), that are commonly used by cancer cells to evade the immune system. TST005 consists of a high affinity PD-L1 antibody fused with an engineered TGF-β Receptor Type II protein in its C-terminal. TST005 lacks FcR binding and has reduced risk of FcR mediated killing of PD-L1 expressing effector T cells. TST005’s PD-L1 high binding activity and enhanced TGF-β trap stability enables the targeted delivery of TGF-β trap into PD-L1 expressing tumors, thereby minimizing off-target toxicities of systemic inhibition of TGF-β signaling. TST005 displayed potent activity in vitro in reversing TGF-β induced T-cell suppression. In multiple syngeneic tumor models, TST005 induced significant increase of CD8 T-cell infiltration into PD-L1 expressing tumors and displayed dose-dependent tumor growth inhibition. TST005 is well tolerated in non-human primates and displayed a linear PK profile. TST005 is a potential novel bi-functional immunotherapy candidate with improved therapeutic window.

On April 15, 2021 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a late clinical-stage biopharmaceutical Company focused on oncology, reported that the Company has presented a poster at the AACR (Free AACR Whitepaper) Annual Meeting, which is being held April 10-15 on a virtual basis (Press release, BioLineRx, APR 15, 2021, View Source [SID1234578065])."

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The poster, entitled: "A Multi-Center Phase 2a Trial of the CXCR4 inhibitor Motixafortide (BL-8040) in Combination with Pembrolizumab and Chemotherapy, in Patients with Metastatic Pancreatic Adenocarcinoma, the COMBAT Study," includes new analyses from the Company’s Phase 2a COMBAT/KEYNOTE-202 triple combination study of motixafortide in metastatic pancreatic cancer, further detailing the clinical effect of the combination in patients with and without liver metastases.

The COMBAT/KEYNOTE-202 study evaluated BioLineRx’s lead clinical candidate, motixafortide, in combination with KEYTRUDA and chemotherapy in patients with advanced pancreatic ductal adenocarcinoma, or PDAC. Top-line results from the study were announced in December 2020.

"Liver metastases are a critical factor driving poor prognoses for patients with metastatic PDAC," stated Dr. Abi Vainstein, Chief Medical Officer of BioLineRx. "We are very pleased to present this additional analysis, which further strengthens the results reported from the COMBAT/KEYNOTE-202 trial in December 2020, since not only were substantially all patients initially diagnosed with stage 4 disease, but the vast majority (~80%) of the patients had liver metastases, emphasizing the extremely difficult patient population in this study. These data should be further confirmed in a randomized trial, and we continue to work diligently to define next steps for the program with potential collaboration partners."

"We believe these incremental data provide strong support for continued development of motixafortide as the backbone of a new regimen for the treatment of PDAC and will likely prove beneficial as we advance discussions with potential collaboration partners," stated Philip Serlin, Chief Executive Officer of BioLineRx. "At the same time, we are very much looking forward to final data from our Phase 3 GENESIS study in stem cell mobilization in the next few weeks, which we hope will give us a clear pathway to potential registration and highlight the versatility of motixafortide across both hematological and solid tumor cancer types."

A copy of the poster is now available on the Company’s website, www.biolinerx.com.

On April 15, 2021 Emergent BioSolutions Inc. (NYSE: EBS) reported that it will host a conference call on Thursday, April 29, 2021 at 5:00 pm eastern time to discuss the financial results for the first quarter of 2021, recent business developments, revenue guidance for the second quarter of 2021, and financial outlook for full year 2021 (Press release, Emergent BioSolutions, APR 15, 2021, View Source [SID1234578084]).

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This conference call can be accessed live by telephone or by webcast:

A replay of the call can be accessed from the Emergent website.

On April 15, 2021 IDEAYA Biosciences, Inc. (NASDAQ: IDYA), a synthetic lethality-focused precision medicine oncology company committed to the discovery and development of targeted therapeutics, reported that the company plans to issue a pre-market press release and conduct a webcast on Friday, April 16, 2021, to discuss clinical data from the ongoing Phase 1/2 trial evaluating darovasertib (IDE196) as monotherapy and darovasertib and binimetinib combination in patients with metastatic uveal melanoma (MUM) (ClinicalTrials.gov Identifier: NCT03947385) (Press release, Ideaya Biosciences, APR 15, 2021, View Source [SID1234578101]).

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IDEAYA will host a Darovasertib Investor Day, including a conference call and webcast with participation of leading clinical investigators, at 8:00 a.m. ET on Friday, April 16, 2021. The link to the webcast of the conference call will be posted on the Investor Relations Events section of the Company’s website at: View Source The update may also be accessed by dialing 1-866-248-8441 (domestic) or 1-720-452-9102 (international) five minutes prior to the start of the call and providing the passcode 2793795. An archived replay will be accessible for 90 days following the event.

IDEAYA also announced the International Nonproprietary Name (INN) for IDE196 is "darovasertib" as registered with the World Health Organization (WHO)’s Programme and Classification of Medical Products.

On April 15, 2021 Race Oncology Limited ("Race") reported to share details of a recent scientific publication in the prestigious journal Nature Communication, confirming Bisantrene is a highly effective inhibitor of the Fat Mass and Obesity associated protein (FTO)1 (Press release, Race Oncology, APR 15, 2021, View Source [SID1234578162]).

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This independent work was performed by a research team at the University of Chicago led by prominent Professors Chuan He and Yu-Ying He, and builds on the original identification of Bisantrene as a potent FTO inhibitor by Professor Chen and his team at the City of Hope Hospital in 20202. Prof. Chuan He’s team was the first to identify FTO as a m6A RNA demethylase3 and its involvement in many cancers.

In this new work, the University of Chicago team has identified that FTO plays a critical role in the development of skin cancers caused by low-level arsenic exposure (which promotes tumour growth) and that Bisantrene-targeted inhibition of FTO limits the growth of these skin cancers in both cell culture and mice.

The importance of this work is highlighted by the ongoing replication crisis in cancer research where many of the most exciting discoveries have not been able to be repeated in independent laboratories4. Independent confirmation of Bisantrene’s ability to target FTO further supports the clinical potential of Race’s Pillar 1 program (ASX announcements: 30 November 2020).