ProMIS Neurosciences Completes US$7M (CDN$8.75M) Financing with Distinguished Group of Boston Based Investors

On March 22, 2021 ProMIS Neurosciences Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, reported that the completion of an US$7M (CDN$8.75M) private placement of convertible unsecured debentures (the "Debentures") (Press release, ProMIS Neurosciences, MAR 22, 2021, View Source [SID1234576949]).

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The investors include Mike Gordon of Fenway Sports Group, the Kraft Group, Henry McCance, co-founder of the Cure Alzheimer’s Fund, and Jeremy Sclar of WS Development Group. "After conducting diligence with a number of experts in the field, we are impressed with the tremendous potential of ProMIS Neurosciences and its unique platform of drug candidates to have a profound impact in the fight against Alzheimer’s and other neurodegenerative diseases. Our group is pleased to provide funding for the next phase of the company’s exciting future", stated Mike Gordon of Fenway Sports Group.

"We are honored to have the support of such a distinguished group of investors, all of whom are accomplished leaders in the business and life sciences arenas" said Gene Williams, ProMIS Executive Chairman.

Debenture Terms

The Debentures are convertible into ProMIS common shares at the option of the holder at a conversion price of US$0.10 per share and accrue interest at 1% per annum, which is payable annually. At the company’s election, accrued interest may be paid in cash or common shares (such number of shares determined by dividing the interest due by the 5-day volume-weighted average trading price or "VWAP" of the common shares).

The Debenture mature on March 22, 2026. Prior to the maturity date, the Company may force conversion of the Debentures at the conversion price upon raising US$50M in equity and/or debt cumulatively. On the maturity date, the Company may redeem the outstanding principal amount of the Debentures in either cash or common shares (at the then 5-day VWAP less a 10% discount) or a combination thereof at its election. Amounts redeemed in common shares on the Maturity Date will be subject to TSX acceptance.

The investors were granted a right to participate, on a pro rata basis, in subsequent company offerings of equity securities for cash consideration pursuant to a public offering or a private placement.

The Debentures and any common shares issued on conversion are subject to a four-month hold period that expires on July 22, 2021. Net proceeds will be used for working capital and general corporate purposes.

ProMIS plans to accelerate progress toward a number of top priorities, including:

Advancing the PMN310 monoclonal antibody, our potential "best in class" next generation Alzheimer’s treatment, into clinical testing;
Enhancing our partnering prospects for programs under active discussion by allowing us to invest in additional validation data;
Expanding our portfolio of products and intellectual property into new target areas, using our proprietary discovery platform;
Advancing our partnered diagnostic programs;
Achieving NASDAQ listing;
Expanding our Board of Directors; and
Expanding our management team, capitalizing on the talent pool in Boston, to support a growing and ambitious scope of activity.
Retirement of our CEO

Finally, a note of great appreciation for our CEO, Dr. Elliot Goldstein. Elliot, who just turned 70, has announced his intention to retire from a full time role by the end of 2021. Even though Elliot is irreplaceable, ProMIS has initiated a search for a new CEO to help us achieve our potential. "Elliot has been a close friend and valued business partner for decades," said Gene Williams, "without his significant contributions, we would not have been able to take ProMIS from just a great science idea to a company with a growing portfolio of therapies that have the potential to be life-altering for patients. On behalf of the entire ProMIS community, and patients who in the future may benefit from our therapies, I offer Elliot our sincere thanks and gratitude".

"ProMIS Neurosciences was launched six years ago based on a world class scientific platform from our CSO and scientific founder, Dr. Neil Cashman. Playing a key role in this endeavor has been one of the most challenging yet rewarding experiences of my 40 odd years in pharmaceutical drug development. I am delighted for this exciting new phase of the Company", stated Dr. Elliot Goldstein, ProMIS CEO.

4D pharma Announces Completion of Merger With Longevity Acquisition Corporation

On March 22, 2021 4D pharma plc (Nasdaq: LBPS; AIM: DDDD) ("4D pharma" or the "Company"), a pharmaceutical company leading the development of Live Biotherapeutic products (LBPs) – a novel class of drug derived from the microbiome – reported completion of its merger ("the Merger") with Longevity Acquisition Corporation ("Longevity")(Nasdaq: LOAC) (Press release, 4d Pharma, MAR 22, 2021, View Source [SID1234576966]).

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4D pharma American Depositary Shares ("ADSs") are expected to begin trading today on the Nasdaq Global Market under the ticker symbol ‘LBPS.’

Warrants of Longevity assumed by 4D pharma in the Merger are currently expected to begin trading on Nasdaq under the ticker symbol ‘LBPSW’ tomorrow, Tuesday, March 23, 2021. Longevity units are expected to be separated and holders thereof are expected receive 4D pharma ADSs and warrants in exchange at the same time as the warrants begin trading.

As a result of the Merger, Longevity shares, warrants, rights and units ceased trading on Nasdaq on Friday, March 19, 2021.

4D pharma ordinary shares continue to be admitted to trading on the London Stock Exchange’s AIM market under the ticker symbol ‘DDDD.’

Xylonix Reveals New Drug Compound for Combating Cancer and Abnormal Macrophages

On March 22, 2021 Xylonix, a Singapore-based biotech company, reported that it has developed a new immunity drug (010DS-Zn) that demonstrates potential for treating a variety of solid cancers and COVID-19’s post-recovery complications, which include heart damage, diabetes and multi-system inflammatory syndrome in children (MIS-C) (Press release, Xylonix, MAR 22, 2021, View Source [SID1234576984]). This research was recently submitted as a preprint publication on bioRxiv.org (View Source).

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Aggressive solid cancers have been known to manipulate immunity for its advancements in several ways. One way is the enrichment of an immunity subset called M2-like macrophages (M2), which is associated in cancer metastasis, relapse, and treatment resistance. Recent studies showed that COVID-19 infection resulted in similar immune pathologies to solid cancers – increased M2 activity and suppressed CD4 and CD8 T-cells[1] activity.

Xylonix demonstrated that its drug compound 010DS-Zn markedly reduced M2 population, while simultaneously boosting anti-cancer CD4 and CD8 T cells. This resulted in tumour suppression in animal studies. It also demonstrated consistent anti-cancer activity in 53 human patient-derived cancers tested ex vivo.

"Today’s cancer immunotherapy combinations can cost upwards of $200,000/year (1), but beneficial responses in patients happen at 15% chance-at-random (2). We developed 010DS-Zn as a widely applicable immunotherapy to significantly increase these odds. As of today, we are concerned about the 120 million and more people (3) with COVID-19 infection history who may suffer from long term recovery complications. We have manufactured sufficient quantity of 010DS-Zn to be used for multiple collaborations, and we are looking for capable partners to work with us on further studies on 010DS-Zn’s effect on human tumours and COVID-19 complications," said Dr Fred Chung, Chief Scientific Officer and Co-founder Xylonix.

• 28th Healthcare Investment Forum, 24th March 2021

On March 22, 2021 Nanoligent reported that it has been selected to showcase at the 28th Healthcare Investment Forum the next 24th of March (Press release, Nanoligent, MAR 22, 2021, http://www.nanoligent.com/index.php/2021/03/22/28th-healthcare-investment-forum/ [SID1234578144]). The Healthcare Barcelona Investment Forum is a meeting point for entrepreneurs and investors in the healthcare sector. All kinds of companies can be presented with projects related to Biotechnology, Medical Devices, Health Services and Information Technologies related to health. The Healthcare Barcelona Investment Forum has positioned itself as a benchmark in the Catalan biomedical ecosystem, promoting innovation and entrepreneurship among the group with the aim of bringing together entrepreneurs and investors in the healthcare sector.

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Coordinated by the Col·legi de Metges de Barcelona, Barcelona Activa – Ajuntament de Barcelona, ESADE-BAN and Biocat, it is the meeting point of reference between entrepreneurs and investors in the healthcare sector. Given the current situation, science, innovation and entrepreneurship in health must not be stopped, with funding being key.

Transactions in connection with share buy-back program

On March 22, 2021 Genmab A/S reported the initiation of a share buy-back program to mitigate dilution from warrant exercises and to honor our commitments under our Restricted Stock Units program (Press release, Genmab, MAR 22, 2021, View Source [SID1234576950]).

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The share buy-back program is expected to be completed no later than June 30, 2021 and comprises up to 200,000 shares.

The following transactions were executed under the program from March 15, 2021 to March 19, 2021:

Details of each transaction are included as an appendix to this announcement.

Following these transactions, Genmab holds 167,477 shares as treasury shares, corresponding to 0.26% of the total share capital and voting rights.

The share buy-back program is undertaken in accordance with Regulation (EU) No. 596/2014 (‘MAR’) and the Commission Delegated Regulation (EU) 2016/1052, also referred to as the "Safe Harbour Regulation." Further details on the terms of the share buy-back program can be found in our company announcement no. 11 dated February 23, 2021.