Invitae to Present at the William Blair 41st Annual Growth Stock Conference

On May 20, 2021 Invitae Corporation (NYSE: NVTA), a leading medical genetics company, reported that members of its management team will present at the William Blair 41st Annual Growth Stock Conference on Thursday, June 3, 2021 at 3:20 p.m. Central / 4:20 p.m. Eastern / 1:20 p.m. Pacific (Press release, Invitae, MAY 20, 2021, View Source [SID1234580366]).

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Invitae’s (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. www.invitae.com (PRNewsFoto/Invitae Corporation)

The live webcast of the fireside chat may be accessed by visiting the investors section of the company website at ir.invitae.com. A replay of the webcast will be available shortly after the conclusion of the fireside chat.

Crescendo Biologics announces initiation of Phase 1 study of CB307 in patients with advanced, PSMA-positive solid tumours

On May 20, 2021 Crescendo Biologics Ltd (Crescendo), a clinical stage immuno-oncology company developing novel, targeted T cell enhancing therapeutics, reported that the first patient has entered the POTENTIA trial, a Phase 1, open-label, monotherapy study of CB307, the most advanced Humabody in Crescendo’s portfolio of T cell enhancers (Press release, Crescendo Biologics, MAY 20, 2021, View Source [SID1234580383]).

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CB307 is a unique, half-life extended Humabody targeting prostate-specific membrane antigen (PSMA) and the potent co-stimulatory molecule CD137 (4-1BB). Monospecific monoclonal antibodies against CD137 have been shown to enhance T cell activity in clinical studies as a cancer therapy, and CB307 is designed to enable potent, conditional and tumour-specific T cell activation whilst avoiding systemic toxicity.

The POTENTIA trial is a Phase 1, multi-centre, non-randomised study of CB307 in patients with advanced and/or metastatic PSMA-positive solid tumours. The study is designed to recruit up to 50 patients across dose escalation and expansion cohorts. The primary endpoint of the trial is to assess the safety and tolerability of CB307 and to determine the maximum tolerated dose.

Additional endpoints include initial evaluation of clinical efficacy, and the trial also includes a comprehensive panel of pharmacokinetic and other translational endpoints. Initial data from the dose escalation part of the trial are expected to be presented at a medical conference in 2022.

More information about the POTENTIA trial can be found on clinicaltrials.gov via NCT04839991 and in the poster recently presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting in April 2021.

Dr Kenji Hashimoto, Chief Medical Officer of Crescendo Biologics, said: "Recent clinical data have provided important validation for both PSMA and CD137 as therapeutic targets. We are therefore delighted to have initiated the CB307 clinical programme with our investigators. CB307 is a unique immuno-oncology therapy which we believe has potential to bring significant benefit to people suffering from hard-to-treat cancers."

Theodora Harold, Chief Executive Officer of Crescendo Biologics, added: "The initiation of the POTENTIA trial is an important milestone for Crescendo as it marks the beginning of clinical development of the first product candidate in our proprietary pipeline of T cell enhancing Humabody therapeutics. We have reached this point thanks to the dedication and focus of the Crescendo team, and we look forward to applying the data emerging from this trial to guide future clinical programmes."

ImmunoGen Announces Webcast of Presentation at Upcoming Jefferies Virtual Healthcare Conference

On May 20, 2021 ImmunoGen Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that Susan Altschuller, Chief Financial Officer, and Anna Berkenblit, Chief Medical Officer, will participate in a fireside chat at the upcoming Jefferies Virtual Healthcare Conference. The presentation is scheduled for June 2, 2021 at 9:30am ET (Press release, ImmunoGen, MAY 20, 2021, View Source [SID1234580399]).

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A webcast of the presentation will be accessible through the Investors and Media section of the Company’s website on www.immunogen.com. Following the live webcast, a replay will be available at the same location.

Indica Labs and Ibex partner to deliver AI-powered clinical workflows for digital pathology

On May 20, 2021 Indica Labs, an industry leader in quantitative digital pathology & image management solutions, and Ibex Medical Analytics, a pioneer in artificial intelligence (AI) based cancer diagnostics, reported an agreement to integrate the Galen AI-based cancer diagnostics platform into the HALO AP digital pathology workflow platform (Press release, Lifescience Newswire, MAY 20, 2021, View Source [SID1234580466]).

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The HALO AP platform was developed by Indica Labs to address the needs of digital Anatomic Pathology labs. The platform can be fully integrated within existing LIS or HIS solutions or can operate as a standalone case and image management system for anatomic pathology. Furthermore, HALO AP supports a full range of tissue-based assays and workflows, including synoptic reporting, tumour boards, secondary consults, quantitative analysis, and AI-assisted workflows. HALO AP is used by some of the largest anatomic pathology laboratories in the world, including NeoGenomics and the National Cancer Institute (NCI).

Ibex’s Galen platform uses strong-AI algorithms that support pathologists in improving the quality of cancer diagnosis and providing productivity-enhancing insights that help reduce turnaround times. Installed in labs worldwide and used as part of everyday clinical practice, Galen routinely detects misdiagnosed and mis-graded cancers in digitized slides, guiding pathologists to areas of cancer in support of a prompt review. In recent clinical studies, the Galen platform demonstrated outstanding clinical outcomes, including the highest accuracy levels reported in the field for prostate cancer, 1- to 2-day reductions in total turnaround time, and 37% productivity gain for pathologists, compared to conventional microscope viewing.
The integration between HALO AP and the Galen platform is designed to enable a seamless experience for the end-user. Galen adds AI-powered cancer detection, case prioritization, grading and other productivity-enhancing insights displayed directly within the HALO AP Platform, so there is no need to use a separate viewer. Where applicable, the data will be communicated with the LIS or HIS system automatically.

"While Indica Labs continues to grow our state-of-the-art AI application pipeline, we also recognize the importance of interoperability with other leaders in this growing field," commented Steven Hashagen, Indica Labs CEO. "A truly seamless integration with Ibex will allow customers to make best-of-breed AI selections without compromising usability."

"Integrated digital pathology and AI workflows are a major driver in supporting pathologists, as they are challenged by ever-increasing workloads and complexity of cancer diagnosis," said Joseph Mossel, CEO and Co-founder of Ibex Medical Analytics. "By joining forces with Indica Labs, we can jointly offer end-to-end solutions enabling pathologists to accelerate adoption of new technologies, strengthen the business case for digitization and improve the quality of cancer care."

BioLineRx to Report First Quarter 2021 Results on May 26, 2021

On May 20, 2021 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a late clinical-stage biopharmaceutical company focused on oncology, reported it will release its unaudited financial results for the quarter ended March 31, 2021 on Wednesday, May 26, 2021, before the US markets open (Press release, BioLineRx, MAY 20, 2021, View Source [SID1234580351]).

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The Company will host a conference call on Wednesday, May 26, 2021 at 10:00 a.m. EDT featuring remarks by Philip Serlin, Chief Executive Officer. The conference call will be available via webcast and can be accessed through the Investor Relations page of BioLineRx’s website. Please allow extra time prior to the call to visit the site and download any necessary software to listen to the live broadcast.

To dial into the conference call, please dial +1-866-744-5399 from the U.S. or +972-3-918-0610 internationally. A replay of the conference call will be available approximately two hours after completion of the live conference call on the Investor Relations page of BioLineRx’s website. A dial-in replay of the call will be available until May 28, 2021; please dial +1-888-295-2634 from the U.S. or +972-3-925-5904 internationally.