On June 17, 2021 Cannabics Pharmaceuticals Inc. (CNBX), a global leader in the development of cancer related cannabinoid-based medicine, reported the expansion of its research program with new drug development projects targeting Prostate Cancer, Neurodegenerative & Mental Health diseases (Press release, Cannabics Pharmaceuticals, JUN 17, 2021, View Source [SID1234584202]). The announcement of the new research projects follows promising initial preclinical results obtained in the company’s in-house drug discovery facility in Rehovot, Israel.

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Study results indicate the potential efficacy of a variety of specific analytes for the indications tested. The experiments performed were conducted on cell lines and human biopsies obtained under Helsinki Committee approval. The company plans to continue development of these drug candidates and continue testing with animal models while entering a drug regulatory development route for each indication.

This announcement also comes following the company’s promising animal model study results for company’s proprietary Colorectal Cancer treatment drug candidate RCC-33. The company has also recently announced a decision to enter the Melanoma and Breast Cancer markets with new drug development projects.

Gabriel Yariv, company President and COO said: "We have invested a great deal of effort over the past 18 months in expanding our drug development projects. In doing so, we have established a drug development pipeline addressing an estimated $78.1B market size. This market is also expected to grow in the coming years. For example, the Breast Cancer market alone is estimated to grow from $21.58B in 2019 to $55.27B in 2027, according to Fortune Business Insights. We now have four cancer treatment drug development projects for Colorectal Cancer (CRC), Melanoma, Breast Cancer and Prostate Cancer; one pre-cancer antitumor drug development project for the treatment of Adenomatous Polyps in collaboration with Digestix Bioscience Inc.; one palliative drug development project for the treatment of Cancer related Anorexia Cachexia Syndrome (CACS); and two early-stage drug discovery projects targeting Neurodegenerative and Mental Health diseases".

Eyal Barad, Cannabics Pharmaceuticals’ Co-founder and CEO commented: "During the past year and a half, we have made announcements of several important milestones that we have achieved, all as part of our strategy focused on creating a portfolio of valuable intellectual property to support our methodology and expanding product pipeline development. Today, we see the outcome of this ongoing effort in looking at our core growth initiatives ultimately aimed at developing products to help large groups of patients around the world and cater to their medical needs, including several of their unmet needs. We continue to put together a robust package for scheduling our Pre IND meeting with the FDA and before heading into human trials. We have doctors and hospitals already looking to collaborate with us on such clinical studies and hope to be able to do so during 2022. In parallel, we continue the development of our new drug candidates and plan to enter animal model studies later this year."

On June 17, 2021 Harbour BioMed ("HBM", HKEX: 02142) reported that the dosing of the first patient of HBM4003 in patients with advanced non-small cell lung cancer in its open phase I clinical study(Press release, Harbour BioMed, JUN 17, 2021, View Source [SID1234584074]). This study will evaluate the safety, tolerability, PK/PD, and anti-tumor activity of HBM4003 in combination with programmed cell death protein 1 (PD-1) antibody in the treatment of solid tumors. The combined study of HBM4003 and PD-1 antibody/chemotherapy for patients with advanced melanoma and other solid tumors completed the first patient first dosing in March 2021.

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"Innovative immunology therapeutics bring more effective and safer treatment to patients. I look forward to recruiting more advanced NSCLC patients that may benefit from this treatment," said Professor Shun Lu, Director of Clinical Medicine Department from Shanghai Chest Hospital.

"Lung cancer is by far the leading cause of cancer death, making up almost 25% of all cancer deaths, and there is an urgent need for innovative drugs and therapeutic solutions for lung cancer treatment," said Dr. Wang Jingsong, Founder, Chairman and CEO of Harbour BioMed. "We will continue to accelerate the global development of HBM4003 for multiple cancers, so that we can help cancer patients around the world to live better and longer lives."

About HBM4003

HBM4003 is the fully human anti-CTLA-4 monoclonal heavy chain only antibody (HCAb) generated from Harbour Mice. HBM4003 shows enhanced antibody-dependent cell cytotoxicity (ADCC) killing activity and is extremely specific to high CTLA-4 Treg cells in tumor tissues. The potent anti-tumor efficacy and differentiated pharmacokinetics with durable pharmacodynamic effect presents a favorable product profile. This novel and differentiated mechanism of action has the potential to improve efficacy while significantly reducing the toxicity of the drug.

On June 17, 2021 OncoNano Medicine, located in a suburb of Dallas, Texas, reported that it raised $50 million for its novel pH-based cancer products in a B round led by Advantech Capital, a China cross border investor(Press release, OncoNano Medicine, JUN 17, 2021, View Source [SID1234584111]). Proceeds of the round will be used to support the Phase II US/EU clinical trials for pegsitacianine, a real-time imaging agent used in intraoperative surgical resection of solid tumors, and to accelerate development of ONM-501, a novel immunoncology molecule. OncoNano was founded by Jinming Gao, PhD, who received his BS from Peking University and PhD from Harvard.

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On June 17, 2021 CNS Pharmaceuticals, Inc. (NASDAQ: CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and metastatic cancers in the brain and central nervous system, reported that as part of the annual reconstitution of the Russell stock indexes, CNS Pharmaceuticals has been selected to be added to the Russell 2000 Index effective June 25, 2021, after the close of the U.S. equity markets (Press release, CNS Pharmaceuticals, JUN 17, 2021, View Source;announces-inclusion-in-the-russell-2000-index-301314307.html [SID1234584146]).

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John Climaco, CEO of CNS Pharmaceuticals, commented "We are pleased to meet this noteworthy milestone and be included in the Russell 2000 Index. As our team continues to drive our clinical program forward for the treatment of glioblastoma multiforme (GBM), we believe this inclusion well-positions us to drive market awareness. We are honored to be listed among our industry peers on what is considered to be a widely respected performance benchmark for small-cap companies. We look forward to leveraging the access and positioning this inclusion brings to unlock additional value."

The Russell 2000 Index measures the performance of the small-cap segment of the US equity market. The Russell 2000 Index is a subset of the Russell 3000 Index representing approximately 10% of the total market capitalization of that index. It includes approximately 2,000 of the smallest securities based on a combination of their market cap and current index membership.

Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $9 trillion in assets are benchmarked against Russell’s U.S. indexes which are part of FTSE Russell, a global index leader that provides innovative benchmarking, analytics and data solutions for investors worldwide.

For more information on the Russell Indexes, please visit the FTS Russell website at www.ftserussell.com.

On June 17, 2021 Cothera Bioscience reported that it has received approval from the U.S. Food and Drug Administration (FDA) to initiate a global multi-center phase 2 clinical trial for the treatment of high-grade B-cell lymphoma that is resistant or refractory to first-line and second-line treatments with PC-002, an inhibitor that targets MYC mutations (Press release, Cothera Bioscience, JUN 17, 2021, View Source [SID1234618852]).

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PC-002 is a first-in-class small molecule drug targeting MYC- mutated tumors. With more than 50% of human cancers showing increased expression, MYC is regarded as one of the most important yet "undruggable" cancer targets. With a unique mechanism of action, PC-002 selectively induces MYC protein degradation and cell apoptosis in MYC-dependent tumors. PC-002 may potentially target multiple indications in cancer involving MYC dysregulation.

Dr. Alex Wu, Co-founder and CEO of Cothera Bioscience, said: "The FDA’s approval of PC-002 to initiate human phase 2 clinical trials is an important milestone for Cothera. I believe this is a good start, and the company will continue its effort to launch late-stage clinical trials for other cancer indications, bringing breakthroughs and better treatment options to more cancer patients."