On May 26, 2021 AXIM Biotechnologies, Inc. (OTCQB: AXIM) ("AXIM Biotech," "AXIM" or "the Company"), an international healthcare solutions company targeting oncological and COVID-19 research, reported that it has completed pre-clinical drug studies on its patent pending compound SPX-1009, demonstrating the suppression of malignant metastatic melanoma cells (Press release, AXIM Biotechnologies, MAY 26, 2021, View Source;utm_medium=rss&utm_campaign=axim-biotechnologies-completes-pre-clinical-drug-studies-on-spx-1009-compound-proving-suppression-of-melanoma-cells [SID1234585596]). The independent research was completed by Dr. Douglas Lake’s laboratory at Arizona State University.

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"We are extremely excited with the results of the in vitro testing," said John W. Huemoeller II, Chief Executive Officer of AXIM Biotechnologies, Inc. "This potential therapeutic treatment could someday help control melanoma growth and metastasis with our compound SPX-1009 in a topical treatment."

Melanoma is the most serious type of skin cancer because of its ability to spread to other organs rapidly if it is not treated at an early stage. According to SkinCancer.org, an estimated 207,390 cases of melanoma will be diagnosed in the U.S. in 2021 and an estimated 7,180 people will die of melanoma in the U.S. in 2021.

SPX-1009 was first screened in a cell-free enzymatic assay for its ability to inhibit Quiescin Sulfhydryl Oxidase I ("QSOX1"), a tumor-derived enzyme that is important for cancer growth, invasion and metastasis, and was then tested for its ability to inhibit growth and invasion of a well-established A375 melanoma cell line and a low-passage patient-derived melanoma. 2D invasion assays and 3D tumor spheroid assays were employed to measure the effect of the compounds on tumor invasion.

As a next step, AXIM intends to initiate animal studies to demonstrate the ability of SPX-1009 to suppress tumor growth and metastasis in a murine model of melanoma. AXIM’s intellectual property related to the SPX-1009 technology is the subject of numerous patent-pending applications.

For more information about AXIM, please visit www.aximbiotech.com.

On May 26, 2021 Luye Pharma Group announced that its holding subsidiary, Boan Biotech, reported that it has signed an agreement with AstraZeneca China regarding the promotion rights to the anticancer drug Boyounuo (Bevacizumab Injection), under which the former will grant to the latter exclusive promotion rights in the county markets across 21 provinces, municipalities and autonomous regions of China (Press release, Boan Biotech, MAY 26, 2021, View Source [SID1234595076]).

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The partnership is based on integrating the strengths and resources of both companies at various levels of markets in China. Boan Biotech will coordinate its own business team, commercial networks and resources in the field of oncology to ensure better access to Boyounuo for patients in key markets. In addition, Boan Biotech will join hands with AstraZeneca to leverage their many years of broad market coverage and channel development in China, especially at the county level, enabling more patients to benefit from the drug.

Boyounuo, a bio-antibody drug developed by Boan Biotech was recently approved for marketing by China’s National Medical Products Administration, for treating advanced, metastatic or recurrent non-small-cell lung cancer and metastatic colorectal cancer. To make it available to patients as quickly as possible, the company arranged the delivery of the first batch of product within ten days of announcing the official approval. Prescriptions have been issued in many cities across the country.

Ms. Hua Jiang, Chief Executive Officer of Boan Biotech said: "AstraZeneca has a broad range of innovative resources and a global network with years of development experience in the oncology therapeutic field and county markets. Our strategic collaboration with AstraZeneca provides an important supplement and extension to the commercial network for Boyounuo. We will leverage our respective strengths in channels and patient coverage at multiple market levels, as well as explore active collaboration opportunities in overseas markets, to provide high-quality and affordable drugs for more patients."

Mr. Leon Wang, Executive Vice President, International and China President at AstraZeneca said: "At AstraZeneca, patients are at the centre of everything we do. Deeply rooted in China county areas for many years, we work with various parties to ensure more patients benefit from innovative holistic disease management solutions. Boan Biotech is a comprehensive biopharmaceutical company with capabilities across the industry value chain, as well as excellent R&D and manufacturing teams. With their position as a leading local company, we are delighted to be working together and looking forward to our close collaboration in the future, bringing more innovative solutions to patients at the county level and expanding on continued efforts to meet the growing health needs in China."

On May 26, 2021 Evelo Biosciences (Nasdaq:EVLO), a clinical stage biotechnology company developing a new modality of orally delivered medicines, reported that management will present at three upcoming virtual investor conferences in June (Press release, Evelo Biosciences, MAY 26, 2021, View Source [SID1234580598]):

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Jefferies Virtual Healthcare Conference. Management will host a presentation at 1:30 p.m. ET on Wednesday, June 2, 2021.

JMP Securities Life Sciences Conference. Management will host a fireside chat at 1:00 p.m. ET on Wednesday, June 16, 2021.

Raymond James Human Health Innovation Conference. Management will host a presentation at 9:20 a.m. ET on Tuesday, June 22, 2021.

Live audio webcasts of the presentations will be available on the Investors section of the Evelo website at View Source A replay of these webcasts will be available for approximately 30 days following each presentation.

On May 26, 2021 GlycoMimetics, Inc. (Nasdaq: GLYC) reported that that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial (IST) evaluating uproleselan as a prophylactic agent to reduce gastrointestinal (GI) toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation (auto-HCT) for multiple myeloma (MM) (Press release, GlycoMimetics, MAY 26, 2021, View Source [SID1234580614]). Dr. Keith Stockerl-Goldstein, M.D., Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine, is the clinical trial’s principal investigator.

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"GI side effects are the dose-limiting toxicities of high-dose melphalan in autologous hematopoietic stem-cell transplantation. Preclinical data have demonstrated a protective effect of uproleselan against mucosal damage and, in the GlycoMimetics Phase 2 trial reported at the American Society of Hematology (ASH) (Free ASH Whitepaper) meeting in 2018, uproleselan demonstrated the potential to mitigate severe mucositis in relapsed and refractory acute myeloid leukemia (AML) patients undergoing intensive chemotherapy," said Eric J. Feldman, M.D., GlycoMimetics’ Chief Medical Officer. "With this background, Washington University clinicians at Siteman Cancer Center will be the first to look closely at the potential of uproleselan to attenuate GI toxicities in multiple myeloma patients undergoing transplant. If this placebo-controlled study demonstrates positive improvements, we believe it will underscore the unique properties of our compound and the potential safety benefits of adding uproleselan to a range of other standard blood cancer therapies where toxicity and durability of response are concerns."

About the Phase 2 Study

The study led by Washington University is a Phase 2, single-center, randomized, double-blind, and placebo-controlled IST designed to evaluate whether prophylactic uproleselan plus standard of care (SOC) compared to placebo plus SOC can reduce diarrhea severity in patients receiving high-dose melphalan conditioning in preparation for auto-HCT in MM. Clinicians will observe for oral mucositis severity and other GI toxicities as secondary endpoints. Exploratory endpoints will also assess minimal residual disease at 100 days post-HCT; soluble E-selectin levels at pre-dose and post-conditioning time points; progression free survival; and overall survival.

Eligible patients undergoing first auto-HCT with melphalan conditioning (200mg/m2) for MM will be randomized in a 1:1 allocation to receive either prophylactic uproleselan plus SOC or placebo plus SOC. Randomization will be stratified by age ≥65 years and <65 years, due to increased frequency of GI toxicity in elderly populations. GlycoMimetics anticipates a data readout from the trial in mid-2022.

Siteman Cancer Center, based at Barnes-Jewish Hospital and Washington University School of Medicine, is a top-ranked National Cancer Institute (NCI)-designated Comprehensive Cancer Center and recently received the NCI’s highest possible rating of "Exceptional" for its research programs.

About Uproleselan

Discovered and developed by GlycoMimetics, uproleselan is an investigational, first-in-class, targeted antagonist of E-selectin. Uproleselan (yoo’ pro le’ sel an), currently in a comprehensive Phase 3 development program in AML, has received Breakthrough Therapy designation from the U.S. Food and Drug Administration and the Chinese Health authority for the treatment of adult AML patients with relapsed or refractory disease. Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance

On May 26, 2021 iTeos Therapeutics, Inc. (Nasdaq: ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients, reported that Michel Detheux, PhD, President and Chief Executive Officer, will present at the Jefferies Virtual Healthcare Conference on Wednesday, June 2, 2021 at 8:00 a.m. ET (Press release, iTeos Therapeutics, MAY 26, 2021, View Source [SID1234580630]).

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A live webcast of the presentation will be available on the Investors section of the company’s website at View Source An archived replay will be available for approximately 30 days following the presentation.