On December 14, 2020 AnPac Bio-Medical Science Co., Ltd. ("AnPac Bio," the "Company" or "we") (ANPC), a biotechnology company with operations in China and the United States focused on early cancer screening and detection, reported it has made significant progress in detecting pre-cancer diseases (Press release, Anpac Bio, DEC 14, 2020, View Source [SID1234572817]). This development was made via novel sensor design, sensor fabrication, detection process, signal collection, signal processing and proprietary algorithms, which has been validated in both multi-year retrospective and prospective, large sample and population studies. The Company recently completed a prospective large population screening of over 110,000 individuals (and over 150,000 samples throughout this study with some individuals tested multiple times over the years) using AnPac Bio’s Cancer Differentiation Analysis (CDA) technology. The follow-up study involved over ~ 13,000 individuals assessed with high cancer risk, medium cancer risk and low cancer risk using AnPac Bio’s CDA technology.
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Initial results indicated that AnPac Bio CDA technology is capable of providing meaningful information while also screening out pre-cancer diseases, with over 20 types of pre-cancer diseases diagnosed following initial screening utilizing CDA technology and subsequent confirmation by hospital or physical testing center health check-ups. Of the over 20 types of screened out pre-cancer cases, thyroid nodule/tumor ranked number one and pulmonary nodule ranked number two, with about 92.5% confirmed pre-cancer patients in medium to high risk cancer groups. Of the ~ 13,000 individuals, AnPac screened out and confirmed pre-cancer cases at roughly 4.5 times of that of cancer cases, strongly demonstrating that AnPac Bio CDA technology is sensitive to detecting pre-cancer diseases and it could play a critical role in cancer prevention.
Developing a viable pre-cancer and early-stage cancer screening technology has been a long-term goal of global scientists. However, its development and progress has been relatively slow, despite years of heavy investment and efforts by leading scientists and research groups. One of key factors inhibiting breakthroughs in cancer detection has been the lack of previous involvement and contributions of leading semiconductor detection experts (with sensor signal collection and processing).
AnPac Bio consists of research and development team with extensive knowledge and experience in detection technologies including novel and advanced detection technologies including highly sensitive sensor design and fabrications, as well as small signal collection and processing. AnPac’s founder, Dr. Chris Yu, graduated from The Pennsylvania State University with a Ph. D. degree in novel detection technology which involved novel sensor design and fabrication, and small signal detection and processing. Mr. Du, vice president of research and development of AnPac Bio, has ten years of extensive integrated circuit (IC) processing and integration experience, which is critical in fabricating highly sensitive cancer detection sensors, at a New York Stock Exchange traded IC manufacturing company prior to joining AnPac Bio.
AnPac Bio has innovated and developed biophysics based detection technology (in which biophysical properties of blood are detected and analyzed) for pre-cancer disease and early stage cancer screening and detection. The Company is also one of the very first companies to champion multi-cancer detection idea and methodology. The employment of biophysical properties for cancer detection is novel and is an alternative approach to traditional methods, with advantages of being able to detect multiple cancer and pre-cancer types earlier, more cost effective, achieves higher sensitivity and specificity, and has relatively simple sample requirements and test procedures. Specifically, it could play an important role in democratizing cancer screening to large populations at an affordable cost.
Dr. Chris Yu, CEO and Chairman of AnPac Bio commented: "We are very pleased to have achieved this significant breakthrough in successfully detecting pre-cancer diseases, which is critical in cancer prevention and saving lives. From a commercialization perspective, this breakthrough has significant ramifications for market and customer needs, and revenue generation potential. AnPac Bio is very proud to be one of the first research groups to have achieved this important technical milestone, which will significantly expand AnPac Bio’s available market size and customer base, and play an important role in revenue generation for years to come."