Celularity Presents Preclinical Data on CYNK-101, its Allogeneic Genetically-Modified Natural Killer Cell Therapy Candidate, at the Society for Immunotherapy of Cancer’s 37th Annual Meeting

On November 10, 2022 Celularity Inc. (Nasdaq: CELU) (Celularity), a clinical-stage biotechnology company developing placental-derived allogeneic cell therapies and biomaterial products, reported that it will present preclinical data on the development of its novel placental-derived allogeneic genetically modified natural killer (NK) cell therapy program CYNK-101 in combination with avelumab. Celularity will report its findings in a poster presentation at the 37th Annual Meeting of The Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) taking place in Boston, Massachusetts and virtually November 8-12, 2022 (Press release, Celularity, NOV 10, 2022, View Source [SID1234623820]).

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Poster no. 270: "Developing placental CD34+-derived natural killer cells with high affinity and cleavage resistant CD16 (CYNK-101) in combination with Avelumab for enhanced therapy against PD-L1+ solid tumors"

Abstract Category: Cellular Therapies, Combinations
Presentation date/time: Friday, November 11, 2022; 7:00 p.m. EST
Room: Boston Convention & Exhibition Center, Hall C
Highlights: CYNK-101 is a cryopreserved, off-the-shelf, allogeneic, placental CD34+ derived NK cell therapy, overexpressing a high IgG binding affinity, proteinase cleavage resistant, CD16 variant. The results demonstrate the synergistic effect of combining CYNK-101 with avelumab to drive antibody-dependent cellular cytotoxicity (ADCC) activity against PD-L1+ solid tumor cells in vitro, including non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), and bladder cancer tumor cells. CYNK-101 cells provide a combination immunotherapy option by harnessing the anti-tumor activities of both targeted biologics and innate cytotoxicity of NK cells. Further development of CYNK-101 in combination with therapeutic antibodies for these solid tumor indications is warranted.