On April 12, 2022 Chimeric Therapeutics (ASX:CHM, "Chimeric") a clinical-stage cell therapy company and an Australian leader in cell therapy, reported that it has entered into a strategic manufacturing partnership with WuXi ATU, a global contract testing and manufacturing organization (CTDMO) (Press release, Chimeric Therapeutics, APR 12, 2022, View Source [SID1234611978]).
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The partnership initially focusses on Chimeric’s two autologous CAR T-cell therapies for solid tumours: CHM 2101 (CDH17 CAR T), currently in late preclinical development for gastrointestinal (GI) cancers and CHM 1101 (CLTX CAR T), currently being evaluated in a single-site phase 1 clinical trial for patients with recurrent or progressive glioblastoma.
CHM 2101 will leverage WuXi ATU’s end-to-end closed loop CAR T process development, Good Manufacturing Practice (GMP) manufacturing and testing platform, aiming to accelerate development towards its planned first-in-human study.
CHM 1101 will leverage WuXi ATU’s scalable manufacturing and analytical testing capacity to enable potential future expansion of the program to multiple additional clinical trial sites and additional solid tumour indications, including metastatic melanoma.
"We are very excited to enter into this partnership with WuXi ATU," said Jennifer Chow, CEO of Chimeric Therapeutics. "With its extensive experience in cGMP manufacturing and analytical testing, as well as its seamless platform process for CAR T-cell production, WuXi ATU is uniquely positioned to support the acceleration and expansion of the CHM 1101 and CHM 2101 development programs."
Dr David Chang, CEO of WuXi Advanced Therapies, added, "We’re delighted to partner with Chimeric Therapeutics to accelerate the development of two of their autologous CAR T cell programs. These treatments offer much needed hope to patients with gastrointestinal cancers or glioblastoma, and we are honoured to support Chimeric Therapeutics as they prepare these treatments for further clinical testing."
This partnership will enable Chimeric to accelerate clinical manufacturing readiness for new CAR T assets and to scale CAR T manufacturing to support multiple, simultaneous, multi-center CAR T clinical trials in the future.