CNS Oncology Publishes Data Suggesting Survival Benefit of Optune™ in Combination with Second Line Chemotherapies after Glioblastoma Recurrence

On April 17, 2017 Novocure (NASDAQ:NVCR) reported that data from a post hoc analysis of the EF-14 pivotal phase 3 clinical trial of Optune in combination with temozolomide for the treatment of newly diagnosed glioblastoma (GBM) have been published in CNS Oncology (Press release, NovoCure, APR 17, 2017, View Source [SID1234518587]). The objective of the pre-specified post hoc analysis was to evaluate the efficacy and safety of Optune when added to physician’s best choice second-line treatment after first disease recurrence among patients enrolled in the EF-14 trial.

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The analysis shows that the median overall survival of patients treated with Optune in combination with physician’s best choice second line chemotherapy increased by 28 percent compared to patients treated with physician’s best choice second line chemotherapy alone from 9.2 months to 11.8 months (HR= 0.70, p= 0.049). Bevacizumab, alone or in combination with chemotherapy, was the most frequently used second-line treatment. The analysis also shows that the median overall survival of patients treated with Optune in combination with bevacizumab increased by 31 percent compared to patients treated with bevacizumab alone from 9.0 months to 11.8 months (HR=0.61, p= 0.043).

"Taken in conjunction with the previously reported benefits with TTFields for newly diagnosed GBM in the EF-14 interim analysis, these results support the early initiation and continued use of Optune in combination with standard systemic therapies for the treatment of GBM," said Santosh Kesari, a trial investigator and Chair of Translational Neurosciences and Neurotherapeutics at John Wayne Cancer Institute and Director of Neuro-oncology at the Pacific Neuroscience Institute at Providence Saint John’s Health Center in Santa Monica, California. "The publication of these data adds to the growing body of evidence around Optune’s efficacy and supports the incorporation of Optune as a combination treatment for patients with glioblastoma."