On June 15, 2020 Codiak BioSciences, Inc., a company at the forefront of advancing engineered exosomes as a new class of biologic medicines, reported that it will present new preclinical data on its exoASO-STAT6 and exoASO-C/EBPβ programs via an oral presentation at the American Association For Cancer Research (AACR) (Free AACR Whitepaper) 2020 Virtual Annual Meeting II on June 23, 2020 (Press release, Codiak Biosciences, JUN 15, 2020, View Source [SID1234561110]).
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Codiak’s exoASO program utilizes its proprietary engEx Platform to engineer exosomes exogenously loaded with an antisense oligonucleotide (ASO). These exosomes are designed to selectively reprogram M2 immunosuppressive macrophages to an M1 pro-inflammatory phenotype by targeting and decreasing the expression of the immunosuppressive transcription factors STAT6 and C/EBPβ.
"These new data are encouraging because they demonstrate that both exoASO-STAT6 and exoASO-C/EBPβ showed significant efficacy when administered intravenously in an aggressive orthotopic model of hepatocellular carcinoma," said Sriram Sathy, Ph.D, Senior Vice President, Preclinical Development at Codiak BioSciences. "We are excited to continue to advance this program through IND-enabling preclinical studies."
Oral Presentation:
Genetic reprogramming of TAMs by engineered exosomes results in potent single agent anti-tumor activity
Abstract Number: 4723
Presentation Number: 5696
Session Title: Novel Immunotherapies and Mechanisms
Date/Time: Tuesday June 23, 2020 from 9:35-9:50 AM ET
About engEx Platform
The engEx Platform is Codiak’s proprietary exosome therapeutic engine for engineering and manufacturing novel exosome product candidates designed to target multiple pathways throughout the body. Using this platform, Codiak can design exosomes with precisely engineered properties, incorporate various types of biologically active molecules and direct them to specific cell types and tissues. These exosomes engage targets by cellular uptake, membrane-to-membrane interaction or a combination of both mechanisms and are designed to change the biological functioning of the recipient cells in order to produce the intended biological effect. Codiak is building a broad pipeline of engEx product candidates that may have a transformative impact on the treatment of many diseases.