On January 13, 2022 Corvus Pharmaceuticals, Inc. (Corvus or the Company) (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, reported that its partner in China, Angel Pharmaceuticals Ltd. (Angel Pharma), has treated the first patient in its Phase 1/1b clinical trial of Corvus’ small molecule ITK inhibitor CPI-818 for the treatment of relapsed/refractory T-cell lymphomas (TCL) in China (Press release, Corvus Pharmaceuticals, JAN 13, 2022, View Source [SID1234605452]).

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"We are excited that Angel has begun to enroll patients in its Phase 1/1b clinical trial of CPI-818, which marks the first clinical use of one of our drug candidates in China," said Richard A. Miller, M.D., co-founder, president and chief executive officer of Corvus. "There is a significant opportunity to address unmet clinical need in China, where TCL are more common than in North America. In addition, we believe this study will accelerate the global development of CPI-818 for lymphomas and other T cell mediated diseases such as autoimmune disorders."

The Angel Pharma Phase 1/1b clinical trial will evaluate various dosing regimens in patients with a variety of TCL, including peripheral T cell lymphoma, angioimmunoblastic T cell lymphoma, NK T cell lymphoma and other T cell lymphomas. Enrolled patients must have failed standard therapies and will receive CPI-818 as a single agent given orally until disease progression. The trial is designed to assess safety, tolerability, pharmacokinetics (PK)/pharmacodynamics (PD), and preliminary efficacy.

Professor Song Yuqin, the lead primary investigator of the CPI-818 Phase 1/1b clinical trial in China and Director of the Chinese Society of Clinical Oncology (CSCO), Secretary-General of the Anti-Lymphoma Alliance of the CSCO, and Deputy Director of Lymphoma Department at Peking University Cancer Hospital, said, "the number of new cases of non-Hodgkin lymphoma in China is about 93,000 per year, of which TCL is a challenging sub-group. We look forward to recruiting more patients that may benefit from this treatment."

Corvus co-founded Angel Pharma to develop its pipeline in greater China and currently holds an equity stake of 49.7% in the company. Angel Pharma licensed the rights from Corvus to develop, manufacture and commercialize CPI-818 in greater China and is responsible for all expenses related to its development in China.