On May 10, 2023 Decibel Therapeutics (Nasdaq: DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, reported that it will present at the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 25th Annual Meeting, being held in Los Angeles, California May 16 – 20th, 2023 (Press release, Decibel Therapeutics, MAY 10, 2023, View Source [SID1234631392]).

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The Company will deliver podium presentations on its lead gene therapy product candidate, DB-OTO, a gene therapy designed to provide hearing to individuals with hearing loss caused by mutations of the otoferlin gene, and its AAV.103 product candidate, a gene therapy designed to restore hearing in individuals with hearing loss caused by mutations of the gap junction beta-2 (GJB2) gene. Decibel will also present posters related to its preclinical pipeline and its platform.

Podium Presentations

Nonclinical Pharmacology, Biodistribution, and Safety Studies Supporting the Clinical Development of DB-OTO (AAV1-Myo15-hOTOFv5) for Hearing Loss Due to Genetic Otoferlin Protein Deficiency
Presenter: Vassili Valayannopoulos, M.D., Ph.D., MBA
Session Title: Pharmacology/Toxicology Studies: Bio Distribution
Date & Time: Friday, May 19, 5:15 – 5:30 p.m. PT
Location: Petree Hall C

Precise Targeting of GJB2 Cells Results in Safe and Efficacious Gene Therapy in a Rodent Model of Hearing Loss Due to GJB2 Deficiency
Presenter: Gabriela Pregernig, Ph.D.
Session Title: Ophthalmic and Auditory Diseases
Date & Time: Saturday, May 20, 9:15 – 9:30 a.m. PT
Location: Room 502 AB

Poster Presentations

Development of a Platform for Parallel Functional Evaluation of Cell Type Specific Synthetic Promoters for Gene Therapy
Poster Board Number: 432
Date & Time: Wednesday, May 17, 12:00 – 2:00 p.m. PT

Restoration of Auditory Function with Otoferlin Gene Transfer Therapy in Nonsense (Q828X) and Missense (pR1934Q and Deaf5) Models of OTOF Deficiency
Poster Board Number: 1115
Date & Time: Thursday, May 18, 12:00 – 2:00 p.m. PT

Rescue of Hearing Loss in a STRC KO Mouse Using Multiple Dual Vector Gene Therapy Strategies
Poster Board Number: 1533
Date & Time: Friday, May 18, 12:00 – 2:00 p.m. PT