On May 18, 2017 Deciphera Pharmaceuticals, a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, reported that a poster presentation that includes updated results from the ongoing Phase 1 clinical study of DCC-2618, the company’s pan-KIT and PDGFR inhibitor, will be presented at the 2017 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting taking place June 2 – 6, 2017, in Chicago, IL (Press release, Deciphera Pharmaceuticals, MAY 18, 2017, View Source [SID1234519252]). Details of the presentation are as follows:
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Poster Title: Pharmacokinetic-driven phase 1 study of DCC-2618 a pan-KIT and PDGFR inhibitor in patients with gastrointestinal stromal tumor (GIST) and other solid tumors.
Author: Filip Janku, M.D., Ph.D., The University of Texas MD Anderson Cancer Center
Session: Poster Discussion Session: Developmental Therapeutics – Clinical Pharmacology and Experimental Therapeutics
Abstract #: 2515
Date and Time: Monday, June 5, 2017, 8:00 AM – 11:30AM (CST)
Poster Discussion Session: Monday, June 5, 2017 11:30 AM-12:45 PM (CST)
"We are very pleased to present these important results and to provide an update on the clinical development of DCC-2618, our pan-KIT and PDGFR inhibitor in development for difficult to treat, KIT and/or PDGFRα-driven cancers with limited therapeutic options," said Michael D. Taylor, Ph.D., Deciphera’s President and Chief Executive Officer.
"These maturing data confirm earlier results presented at the 2016 EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Symposium on Molecular Targets and Cancer Therapeutics," added Oliver Rosen, M.D., Deciphera’s Chief Medical Officer. "The encouraging clinical activity achieved in patients with a broad spectrum of mutations and prior therapies in our Phase 1 study supports the impressive translational data presented last month at the 2017 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting".
About DCC-2618
DCC-2618 is currently in a first-in-human Phase 1 clinical trial. DCC-2618 is a pan-KIT and PDGFRα kinase switch control inhibitor in clinical development for the treatment of KIT and/or PDGFRα-driven cancers, including gastrointestinal stromal tumors, glioblastoma multiforme and systemic mastocytosis.