On May 17, 2022 Diffusion Pharmaceuticals Inc.(NASDAQ: DFFN) ("Diffusion" or the "Company"), a biopharmaceutical company developing novel therapies that enhance the body’s ability to deliver oxygen to areas where it is needed most, reported that Robert Cobuzzi, Jr., Ph.D., the Company’s President and Chief Executive Officer, will be presenting at the H.C. Wainwright Global Investment Conference being held at the Fontainebleau Miami Beach Hotel from May 23-26, 2022 (Press release, Diffusion Pharmaceuticals, MAY 17, 2022, https://www.diffusionpharma.com/press-release/diffusion-pharmaceuticals-to-present-at-h-c-wainwright-global-investment-conference/ [SID1234615256]).

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The presentation will be virtual and will provide an overview of recent business and corporate achievements at Diffusion, including an update on TSC clinical trials.

Details of the presentation are as follows:

Date & Time: On demand, beginning 7.00 a.m. ET, Tuesday, May 24, 2022

A replay of the presentation will be available under the presentations section of the Company website at www.diffusionpharma.com. In addition, Dr. Cobuzzi will be available for one-on-one meetings during the conference. Registered investors will be able to request a meeting with management via the conference portal.