On November 10, 2022 Domain Therapeutics ("Domain" or "the Company"), a drug discovery and development company focused on G Protein-Coupled Receptors (GPCRs) in immuno-oncology, reported that new data on its proprietary GPCR programs at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting in Boston, US. Domain is presenting three poster sessions at the conference on DT-9081, its clinical candidate EP4R antagonist, and on its CCR8 depleting-antibody program (Press release, Domain Therapeutics, NOV 10, 2022, View Source [SID1234623679]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
The preclinical data being presented on Domain’s immuno-oncology candidate, DT-9081, shows that the drug candidate was able to demonstrate strong anti-tumor effects in two cancer models with notable synergies with immune checkpoint inhibitors to induce long lasting complete responses. DT-9081 has completed regulatory development and is due to enter the clinic by the end of 2022. The phase I multi-center open label study will assess the safety, tolerability and preliminary efficacy of the asset.
Domain is also presenting preclinical proof-of-principle data on its CCR8 depleting-antibody program, which represents an attractive target from which to derive novel immunotherapies. Data from the studies shows that treatment with a depleting anti-mCCR8 antibody in monotherapy was able to translate into robust anti-tumor activity in multiple models, with induction of a potent and long-lasting tumor-specific memory effect. Domain has successfully discovered a patent-protected library of antibodies with distinct and differentiated binding and activity profiles with the potential to drive the development of a best-in-class CCR8 depleting-antibody for the treatment of cancers.
Pascal Neuville, CEO at Domain Therapeutics, commented: "The new data being presented at SITC (Free SITC Whitepaper) highlights the promising potential of our GPCR programs. We look forward to revealing our exciting findings on both DT-9081 and the CCR8 antibody series, demonstrating the unique features of our proprietary assets. More broadly, Domain has a rich pipeline of differentiated assets with best-in-class and first-in-class potential focused on GPCR targets in immuno-oncology, which we believe has the capacity to address a range of cancers and offer game-changing therapies for patients."