On April 17, 2023 Dyve Biosciences, Inc. ("Dyve"), a clinical-stage platform biotechnology company with assets in immunology and oncology, reported that preliminary data from the ongoing pre-clinical partnership with the H. Lee Moffitt Cancer Center & Research Institute will be presented at a poster presentation at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting, taking place April 14-19, 2023, in Orlando, Florida (Press release, Dyve Biosciences, APR 17, 2023, View Source [SID1234630149]).
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Dyve will present pre-clinical data from its lead oncology drug candidate, DYV800, a pH modulating agent that targets tumor microenvironment (TME) acidity in solid tumors. DYV800, delivered topically to bypass gastrointestinal absorption challenges, neutralizes the TME acidity that plays a strong role in tumor progression (invasion, metastasis, angiogenesis), immune escape, and treatment resistance (radiation, chemotherapy, and immunotherapy).
"Dyve continues to advance research in areas where we believe our pH modulation program can achieve the biggest impact for patients and we look forward to sharing new pre-clinical data on our DYV800 program at this year’s AACR (Free AACR Whitepaper). We believe we have a unique delivery approach that can unlock the powerful effects of neutralizing TME acidity, and this dataset is further validation of that," said Ryan Beal, M.D., Chief Executive Officer, Dyve.
Poster Presentation Details:
Abstract Title: Transdermal alkalinization treatment induces pH changes in a murine melanoma model as measured with MRI-CEST pH imaging
Session Category: Tumor Biology
Session Title: Photoacoustic Ultrasound, and Fluorescence Imaging
Session Date and Time: Monday, April 17, 2023, 1:30 PM – 5:00 PM
Presenter: Dr. Pietro Irrera, H. Lee Moffitt Cancer Center & Research Institute
Location: Convention Center, Section 2, Poster Board 13
Abstract Presentation Number: 2391