Endocyte to Present at the IASLC 17th World Conference on Lung Cancer

On December 1, 2016 Endocyte, Inc. (NASDAQ:ECYT), a leader in developing targeted small molecule drug conjugates (SMDCs) and companion imaging agents for personalized therapy, reported that data from ongoing phase 1 trials of Endocyte’s SMDC EC1456 will be presented at the IASLC 17th World Conference on Lung Cancer on Wednesday, Dec. 7, at 2:30 P.M. CET (Press release, Endocyte, DEC 1, 2016, View Source [SID1234516879]). The conference will be held at the Messe Wien Exhibition & Congress Center in Vienna, Austria.

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The presentation will be available on Endocyte’s website following presentation at the conference.

Presentation is as follows:

Poster Presentation: Phase 1 Dose Escalation, Safety and Pharmacokinetic Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Patient Subset
When: Wednesday, December 7th, 2:30 p.m. – 3:45 p.m. CET, Hall B
Track: Advanced NSCLC
Presenter: Martin J. Edelman, University of Maryland Greenebaum Cancer Center, Baltimore
About EC1456 and etarfolatide

EC1456 is an investigational therapeutic SMDC constructed of folic acid conjugated through a spacer and releasable linker system to a potent cytotoxic microtubule inhibitor, TubBH. The high affinity of the folic acid ligand for the FR allows for the active and specific targeting of EC1456 to FR-expressing cancer cells. The FR is highly expressed in several epithelial cancers (e.g. ovarian, NSCLC) but is expressed at low levels in most normal tissues.

Etarfolatide is an FR-targeted companion imaging agent being co-developed to characterize whole body FR expression in real time, to identify patients most likely to benefit from EC1456 therapy. EC1456 and etarfolatide are currently being evaluated in a phase 1 study in patients with advanced solid tumors (ClinicalTrials.gov Identifier: NCT01999738).