Enlivex Announces Issuance of European Patent Covering the Use of Allocetra™ to
Prevent Cytokine Release Syndrome (CRS) Resulting from CAR T-Cell Therapy

On May 8, 2023 Enlivex Therapeutics Ltd. (Nasdaq: ENLV, the "Company"), a clinical-stage macrophage reprogramming immunotherapy company, reported the issuance of a European patent, numbered 3865189, entitled, "Combination Immune Therapy and Cytokine Control Therapy for Cancer Treatment (Press release, Enlivex Therapeutics, MAY 8, 2023, View Source [SID1234631140])." The patent provides added intellectual property protection in Europe into at least 2037, with claims covering the use of for Allocetra for the prevention or amelioration of cytokine storms in cancer patients receiving CAR T-Cell therapy.

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ABOUT ALLOCETRA

Allocetra is being developed as a universal, off-the-shelf cell therapy designed to reprogram macrophages into their homeostatic state. Diseases such as solid cancers, sepsis, and many others reprogram macrophages out of their homeostatic state. These non-homeostatic macrophages contribute significantly to the severity of the respective diseases. By restoring macrophage homeostasis, Allocetra has the potential to provide a novel immunotherapeutic mechanism of action for life-threatening clinical indications that are defined as "unmet medical needs", as a stand-alone therapy or in combination with leading therapeutic agents.