On November 9, 2022 Arrowhead Pharmaceuticals, Inc. (the "Company") reported that entered into a Royalty Purchase Agreement (the "Purchase Agreement") with Royalty Pharma Investments 2019 ICAV ("Royalty Pharma"), pursuant to which Royalty Pharma agreed to pay up to $410 million in cash to the Company in consideration for the Company’s future royalty interest in Olpasiran, a small interfering RNA (siRNA) originally developed by the Company and licensed to Amgen in 2016 under that certain Second Collaboration and License Agreement (the "License Agreement") (Filing, 8-K, Arrowhead Research Corporation, NOV 9, 2022, View Source [SID1234623701]).

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Pursuant to the Purchase Agreement, Royalty Pharma paid $250 million upfront and agreed to pay up to an additional $160 million in aggregate one-time milestone payments due if and when the following milestone events occur: (i) $50 million on completion of enrollment in the planned OCEAN Phase 3 clinical trial for Olpasiran, (ii) $50 million upon receipt of FDA approval of Olpasiran for an approved indication (reduction in the risk of myocardial infarction, urgent coronary revascularization, or coronary heart disease death in adults with established cardiovascular disease and elevated Lp(a)), and (iii) $60 million upon Royalty Pharma’s receipt of at least $70 million of royalty payments under the Purchase Agreement in any single calendar year.

In consideration for the payment of the foregoing amounts under the Purchase Agreement, Royalty Pharma is entitled to receive all royalties otherwise payable by Amgen to the Company under the License Agreement. The Company remains eligible to receive any milestone payments potentially payable by Amgen under the License Agreement.

The Purchase Agreement contains other customary terms and conditions, including representations and warranties, covenants, and indemnification obligations in favor of each party. The above description of the Purchase Agreement is a summary of the material terms, does not purport to be complete and is qualified in its entirety by reference to the Purchase Agreement, which will be filed as an exhibit to the Company’s Quarterly Report on Form 10-Q for the quarter ending December 31, 2022.