On May 15, 2019 Epic Sciences, Inc. reported its poster presentations for the upcoming 2019 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting taking place May 31 through June 4 in Chicago, Illinois (Press release, Epic Sciences, MAY 15, 2019, View Source [SID1234536365]). The data to be presented by Epic researchers and its partners feature multiple novel circulating tumor cell (CTC) biomarkers associated with therapeutic response to different drug classes including PARP inhibitors, androgen-targeted therapies and checkpoint inhibitors for prostate and bladder cancer.

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"This new data further strengthens the clinical evidence of CTCs to predict disease progression and response to different cancer therapies," said Rick Wenstrup, M.D., chief medical officer at Epic Sciences. "There are a number of very exciting, novel therapies for cancer in development, and we are working with several biopharma and academic clinical researchers to utilize Epic’s functional cell profiling technology platform as part of their biomarker strategies. Our CTC approach creates opportunities for drug developers to optimize and enrich their clinical trials, and ultimately for oncologists and patients to benefit from predictive information that could extend lives."

Five presentations are listed below:

Title: CTC vs. biopsy tissue sequencing: A concordance analysis of genomic copy number profile from mCRPC patients (pts)
First Author: Howard I. Scher, M.D., FASCO, Memorial Sloan Kettering Cancer Center
Date and Time: Saturday, June 1, 2019, 8:00 am – 11:00 am CT
Poster Session: Developmental Therapeutics and Tumor Biology (Nonimmuno)
Abstract: 3050
Poster Board: 42

Title: Examination of the additive value of CTC biomarkers of heterogeneity (Het) and chromosomal instability to nuclear-localized (nl) AR-V7+ CTCs in prediction of poor outcomes to androgen receptor signaling inhibitor (ARSi) in metastatic castration resistant prostate cancer (mCRPC)
First Author: Howard I. Scher, M.D., FASCO, Memorial Sloan Kettering Cancer Center
Date and Time: Saturday, June 1, 2019, 1:15 pm – 4:15 pm CT
Poster Session: Genitourinary (Prostate) Cancer
Abstract: 5075
Poster Board: 187

Title: SLFN11 expression in advanced prostate cancer (APC) predicts response to platinum-based chemotherapy (PLT)
First Author: Vincenza Conteduca, M.D., Ph.D., Dana Farber Cancer Institute
Date and Time: Saturday, June 1, 2019, 1:15 pm – 4:15 pm CT
Poster Session: Genitourinary (Prostate) Cancer
Abstract: 5065
Poster Board: 177

Title: Pamiparib, an investigational PARP inhibitor in patients with metastatic castration-resistant prostate cancer (mCRPC) and a circulating tumor cell (CTC) homologous recombination deficiency (HRD) phenotype or BRCA defects: A trial in progress
First Author: Simon Chowdhury, M.D., Guy’s, King’s and St. Thomas’ Hospitals, and Sarah Cannon Research Institute
Date and Time: Saturday, June 1, 1:15 pm – 4:15 pm CT
Poster Session: Genitourinary (Prostate) Cancer
Abstract: TPS5086
Poster Board: 198a

Title: Circulating tumor cell (CTC) enumeration in patients (pts) with metastatic genitourinary (mGU) tumors treated in a phase I study of cabozantinib and nivolumab (CaboNivo) +/- ipilimumab (CaboNivoIpi)
First Author: Andrea B. Apolo, M.D., Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH
Date and Time: Monday, June 3, 2019, 1:15 pm – 4:15 pm CT
Poster Session: Genitourinary (Nonprostate) Cancer
Abstract: 4555
Poster Board: 381