On May 15, 2020 Exicure, Inc. (NASDAQ: XCUR), the pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA) constructs, reported that it will present at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II, occurring June 22 – 24, 2020 (Press release, Exicure, MAY 15, 2020, View Source [SID1234558163]).
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The AACR (Free AACR Whitepaper) poster, by the AST-008 Phase 1b/2 study investigators and Exicure, titled "Phase 1b/2 Study of an Intratumoral TLR9 Agonist Spherical Nucleic Acid (AST-008) and Pembrolizumab: Evidence of Immune Activation" will present updated pharmacodynamic and safety data of AST-008 alone and in combination with pembrolizumab from Exicure’s ongoing Phase 1b/2 study (ClinicalTrials.gov identifier: NCT03684785). AST-008 is a novel SNA configuration of a toll-like receptor 9 (TLR9) agonist oligonucleotide, designed to trigger anti-tumor immune responses.
Data to be presented include:
Gene expression analysis from biopsied tumors, showing trends to increased lymphocytes in the injected tumor after intratumoral (IT) AST-008 and in both injected and un-injected tumors after IT AST-008 plus pembrolizumab combination therapy
Dose dependent activation of key immune cells and immune system signal proteins (cytokines/chemokines) after IT AST-008 treatment and AST-008 plus pembrolizumab treatment
An emerging safety profile consisting of mostly injection site reactions and flu-like symptoms, likely reflecting local and systemic immune activation
No AST-008-related serious adverse events or dose limiting toxicity have been reported
This poster will be presented during the AACR (Free AACR Whitepaper) Virtual Meeting II in the session Late-Breaking Research: Clinical Research 1 / Endocrinology under abstract number LB-140. The poster will be available for viewing starting on June 22nd.