On October 22, 2020 F-star Therapeutics Ltd., a clinical-stage immuno-oncology company focused on transforming the lives of patients with cancer through the development of innovative tetravalent bispecific (mAb2) antibodies, reported that it will present two posters at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 35th Virtual Annual Meeting being held from Monday, November 9, 2020 to Saturday, November 14, 2020 (Press release, F-star, OCT 22, 2020, View Source [SID1234568881]).
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The posters will focus on FS118, F-star’s potentially first-in-class, tetravalent bispecific antibody that simultaneously blocks both the LAG-3 and PD-L1 immunosuppressive pathways. FS118 has preclinically and, in preliminary clinical data, demonstrated potent anti-tumor growth activity as well as a highly differentiated mechanism of action when compared to checkpoint monotherapies alone or in combinations.
Abstracts are available on the SITC (Free SITC Whitepaper) website and the accompanying posters will be available in the Virtual Poster Hall open from 8:00 am EST on Monday, November 9, until the Virtual Poster Hall closes on December 31, 2020.
Details of the poster presentations:
Title: A First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1, in Patients with Advanced Cancer and Resistance to PD-(L)1 Therapy
Live Q&A: Poster #395 – Wednesday, Nov. 11 from 5:15-5:45 p.m. EST and Friday, Nov. 13 from 4:40-5:10 p.m. EST
Title: FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1, Induces LAG-3 Shedding Resulting in Receptor Downregulation by T Cells via a Novel mechanism of Action
Live Q&A: Poster #715 – Wednesday, Nov. 11 from 5:15-5:45 p.m. EST and Friday, Nov. 13 from 4:40-5:10 p.m. EST