Foundation Medicine Launches Molecular Residual Disease (MRD) Test for Research Use in Early to Late-Stage Cancers Through its FlexOMx™ Lab

On September 23, 2025 Foundation Medicine, Inc., a precision medicine company transforming lives in cancer care and beyond, reported the addition of a tissue-informed whole genome sequencing molecular residual disease (Tissue-informed WGS MRD) test to its portfolio of high-quality testing solutions (Press release, Foundation Medicine, SEP 23, 2025, View Source [SID1234656180]). The test is currently available for research use in retrospective clinical trials.

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Foundation Medicine’s FlexOMx Lab now offers highly sensitive Tissue-informed WGS MRD test results for early and late-stage cancer research studies. The test monitors hundreds to thousands of tumor-specific variants, enabling accurate quantification of circulating tumor DNA (ctDNA) in patients with cancer for a more complete picture after treatment. Foundation Medicine’s method offers high sensitivity and specificity in detecting potential cancer recurrence, even in samples with low tumor burden where other methods might misinterpret the signal as noise. In a feasibility study, Foundation Medicine’s test was able to find tumor DNA at low levels, down to 1 part per 100,000 (10ppm, 0.001%).

"Foundation Medicine is setting a new standard for how our biopharmaceutical partners can monitor and understand cancer," said Troy Schurr, chief biopharma business officer at Foundation Medicine. "Our new Tissue-informed WGS MRD test gives partners a new tool for exploratory analysis in early to late-stage cancers, that offers highly specific and deep insights into a patient’s response and resistance to therapy."

Foundation Medicine’s Tissue-informed WGS MRD test allows biopharmaceutical partners to unlock rich multi-omics insights with an expanded monitoring portfolio that includes FoundationOneMonitor for research use, a tissue-free treatment monitoring test.

For an even deeper look, biopharmaceutical partners can leverage Foundation Medicine’s Tissue-informed WGS MRD test with the clinical trial assays based on FoundationOneCDx or FoundationOneLiquid CDx for comprehensive genomic profiling and identification of resistance mutations.