On October 7, 2021 -Gennao Bio, a privately-held genetic medicines company developing first-in-class, targeted nucleic acid therapeutics, reported new preclinical data for its gene monoclonal antibody (GMAB) platform technology was presented as a virtual poster presentation at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) (Press release, Gennao Bio, OCT 7, 2021, View Source [SID1234590950]).
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The results presented demonstrate GMAB’s ability to systemically target and deliver an RNA payload to central nervous system (CNS) tumors in a mouse model of human medulloblastoma (DAOY). Studies conducted with fluorescently labeled GMAB show that the antibody readily penetrates into the central nervous system, and is quickly internalized and retained by tumors. Additional studies combining GMAB with 3p-hpRNA, a known activator of the immune signaling RIG-I pathway, show more than 50% reduction in intracranial tumor burden and suppression of spinal metastases following a single dose.
"The results presented today further reinforce the potential of our GMAB platform in oncology and support continued advancement. We look forward to nominating our first clinical program by the end of the year," said Stephen Squinto, Ph.D., chief executive officer and chair of the board of Gennao Bio.
"Treating CNS tumors systemically is challenging given the need to cross the blood-brain barrier and often requires the use of complicated formulations and invasive methods of delivery," said Peter M. Glazer, M.D., Ph.D., Chair of the Department of Therapeutic Radiology, Professor of Genetics and Robert E. Hunter Professor of Therapeutic Radiology at the Yale School of Medicine. "These promising results highlight a novel, non-invasive, targeted approach for the systemic delivery of immunostimulatory RNAs to multiple tumors, offering the potential for improved treatments options over current approaches."
The full abstract and poster presentation can be accessed on the AACR (Free AACR Whitepaper)-NCI-EORTC conference website.