On April 11, 2023 Genomic Testing Cooperative, LCA (GTC) reported that it will be presenting data at the 2023 American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting demonstrating that its targeted transcriptomic profiling correlates with immunohistochemistry (IHC)-based testing (Press release, Genomic Testing Cooperative, APR 11, 2023, View Source [SID1234629940]). Targeted transcriptomic data generated in GTC’s routine genomic profiling of tumors is used to quantify various IHC-based biomarkers including HER2, PD-L1, estrogen Receptor (ER), androgen receptor and others. GTC studies demonstrate that RNA sequencing of clinically relevant genes using next generation sequencing (NGS) provides reliable quantitative data that can be interpreted objectively. This data when used in artificial intelligence (AI) algorithms can predict levels of PD-L1 not only in tumor cells, but also in inflammatory cells. The current data suggests that transcriptomic data can replace the need for some IHC test and potentially may better address clinically relevant questions such as determining low HER2 level and others.
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"We believe that transcriptomic profiling is essential in today’s molecular profiling of cancers. Targeted transcriptomic allows us to focus on the clinically relevant genes and provides better dynamic range." stated Dr. Maher Albitar, founder, chief medical officer, and chief executive officer of GTC. "The generated data when used in AI algorithms allows us to develop new clinical applications and answer clinical questions that few years ago, we thought not possible to answer in routine clinical testing. GTC is leading in this field" added Dr. Albitar.
This data will be presented in the following three posters:
– Predicting PD-L1 status in solid tumors using transcriptomic data and artificial intelligence algorithms: Session Date and Time: Tuesday Apr 18, 2023 9:00 AM – 12:30 PM (4337 / 12)
– Real-world transcriptomic biomarkers as replacement for immunohistochemistry and FISH studies in breast cancer: Session Date and Time: Sunday Apr 16, 2023 1:30 PM – 5:00 PM(967 / 18)
– The molecular landscape of premenopausal versus postmenopausal breast cancer in patients without inherited predisposition mutations: Session Date and Time: Sunday Apr 16, 2023 1:30 PM – 5:00 PM (929 / 12)
Visit GTC booth #1775 at AACR (Free AACR Whitepaper) for more detail and highlights on this work and on how to become a member of the Co-Op.