On March 29, 2022 Genor Biopharma (Stock code: 6998.HK) reported that the company has obtained the EC approval from the Bellberry HREC Ethics Committee in Australia, for the first-in-human (FIH) clinical trial of GB263T, a novel EGFR/cMET/cMET trispecific therapeutic antibody, in patients with advanced Non-Small Cell Lung Cancer (NSCLC) and other solid tumors (Press release, Genor Biopharma, MAR 29, 2022, View Source [SID1234656304]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Meanwhile, China IND application was officially accepted by NMPA on March 28, 2022.

GB263T is a highly differentiated EGFR/cMET/cMET tri-specific antibody targeting EGFR and two different epitopes of cMET. The research and development of GB263T fully demonstrated the advantages of cross-team collaboration and helped to expand the organization’s international capabilities and reach. Working closely with globally renowned KOLs, the clinical trial protocol was finalized on the date of obtaining the toxicology data, substantially speeding up submission to the EC.