Grail Introduces State-of-the-Art Methylation-Based Solution to Accelerate Cancer Research in the Post-Diagnosis Setting

On January 9, 2023 GRAIL, LLC, a healthcare company whose mission is to detect cancer early when it can be cured, reported the availability of a state-of-the-art research use only offering for biopharmaceutical companies (Press release, Grail, JAN 9, 2023, View Source [SID1234626137]). The new technology solution uses GRAIL’s proprietary targeted methylation platform to analyze cell-free DNA (cfDNA) isolated from peripheral blood for cancer signal interrogation. Potential research use cases include, but are not limited to, prognosis, minimal residual disease detection, and recurrence monitoring across different cancer types in research studies.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"GRAIL’s unique methylation technology and bioinformatics capabilities are well suited for circulating tumor DNA analysis across the cancer continuum," said Bob Ragusa, Chief Executive Officer at GRAIL. "We are excited to further leverage our methylation platform and introduce our RUO technology solution for cancer prognosis, minimal residual disease and recurrence monitoring and biomarker discovery. The new technology solution has the versatility to be used in solid tumor research and can be customized to improve performance in specific use cases, including custom classifier development."

GRAIL’s RUO technology solution estimates tumor burden based on methyl variant allele fraction (MVAF), enabling longitudinal monitoring and surveillance solutions. Data from GRAIL studies have demonstrated analytically validated performance, and robust analytical sensitivity, specificity, and precision. The blood-only liquid biopsy approach eliminates challenges with obtaining tissue samples and avoids bias due to tumor heterogeneity or tumor escape mechanisms. The low input requirements support retrospective research studies.