On May 7, 2018 Gritstone Oncology, Inc., an immuno-oncology company developing personalized cancer immunotherapies to fight multiple cancer types, reported that that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for Gritstone’s patent application, "Neoantigen identification, manufacture, and use" 2017/0212984 for its EDGE (Epitope Discovery in cancer GEnomes) technology, a deep learning model designed to identify neoantigens for inclusion in personalized cancer immunotherapies (Press release, Gritstone Oncology, MAY 7, 2018, View Source [SID1234526153]).
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The allowed patent application covers the use of the EDGE technology, particularly where the model was trained using mass spectrometry data. In this allowed patent application, which will result in an issued patent in the coming weeks, Gritstone’s deep learning platform has demonstrated significant innovation over existing prediction tools. Gritstone’s use of the EDGE technology meaningfully increases the odds that the neoantigens selected for inclusion in an immunotherapy will elicit anti-tumor immunity. Any company seeking to use mass spectrometry as a basis to improve neoantigen prediction will need to address this allowed application in their future development plans.
"We have been focused on building a best-in-class neoantigen prediction model since day one of Gritstone’s existence," said Andrew Allen, M.D., Ph.D., co-founder, president and chief executive officer of Gritstone, "and we are happy to now have a robust model that is ready for clinical application following our expected IND submission in the second half of 2018. A good prediction model is key to the success of our neoantigen-based immunotherapy, and we have been pioneering the application of mass spectrometry and deep learning tools to this complex and clinically important biological problem. We are very pleased to have received this Notice of Allowance from the USPTO, as we work to enhance treatment options for patients with difficult-to-treat cancers."