Heat Biologics Presents Positive ComPACT Preclinical Data at the Keystone Symposia

On March 07, 2016 Heat Biologics, Inc. ("Heat") (Nasdaq:HTBX), an immuno-oncology company developing novel therapies that activate a patient’s immune system against cancer, reported positive preclinical data from its next generation ComPACT platform technology, which combines a T cell priming vaccine and T cell co-stimulator in a single product, were presented as both an oral presentation and poster at the Keystone Symposia on Cancer Vaccines: Targeting Cancer Genes for Immunotherapy, held in Whistler, British Columbia, Canada on March 6-10, 2016 (Press release, Heat Biologics, MAR 7, 2016, View Source [SID:1234509402]). Data presented showed that ComPACT secreting OX40L generated the most potent immune response among other ComPACT co-stimulator variations including TL1A, 4-1BBL and ICOSL, as well as compared to systemic delivery of OX40 agonist antibody and vaccine alone.

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A copy of the poster entitled "Combination Immunotherapy: T cell costimulation (OX40L, TL1A, 4-1BBL and ICOSL) secreted locally by Gp96-Ig vaccines elicits robust antigen-specific memory T cell responses and tumor elimination" will be made available in the Publications section of Heat’s corporate website.

About ComPACT

Currently in preclinical development, ComPACT represents a potential dual-acting immunotherapy, combining a pan-antigen T cell priming vaccine and a T cell co-stimulator in a single product. Heat has developed its first ComPACT product candidate, HS-120, as a potential treatment for non-small cell lung cancer (NSCLC) and anticipates filing an Investigational New Drug (IND) application by the end of 2016.